Patents by Inventor Theobald Matthias

Theobald Matthias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for rational mutagenesis of ?/?T-cell receptors and correspondingly mutated MDM2-protein specific ?/?T-cell receptors
    Patent number: 9062127
    Abstract: The invention relates to the rational mutagenesis of polypeptides of ?/? T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific ?/? T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: June 23, 2015
    Assignee: JOHANNES GUTENBERG-UNIVERSITAT MAINZ
    Inventors: Ralf-Holger Voss, Theobald Matthias
  • Method for Rational Mutagenesis of Alpha/Beta T-Cell Receptors and Correspondingly Mutated MDM2-Protein Specific Alpha/Beta T-Cell Receptors
    Publication number: 20110243995
    Abstract: The invention relates to the rational mutagenesis of polypeptides of ?/? T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific ?/? T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
    Type: Application
    Filed: November 23, 2010
    Publication date: October 6, 2011
    Applicant: JOHANNES GUTENBERG-UNIVERSITÄT MAINZ
    Inventors: Ralf-Holger Voss, Theobald Matthias
  • Method for rational mutagenesis of ?/? t-cell receptors and correspondingly mutated mdm2-protein specific ?/? t-cell receptors
    Patent number: 7871817
    Abstract: The invention relates to the rational mutagenesis of polypeptides of ?/? T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific ?/? T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: January 18, 2011
    Assignee: Johannes Gutenberg-Universitat Mainz
    Inventors: Ralf-Holger Voss, Theobald Matthias
  • Method for rational mutagenesis of alpha/beta t-cell receptors and correspondingly mutated mdm2-protein specific alpha/beta t-cell ceceptores
    Publication number: 20060166314
    Abstract: The invention relates to the rational mutagenesis of polypeptides of ?/? T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific ?/? T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
    Type: Application
    Filed: September 24, 2003
    Publication date: July 27, 2006
    Inventors: Ralf-Holger Voss, Theobald Matthias