Patents by Inventor Theodor Chitlaru

Theodor Chitlaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HtrA-defective-derived vaccines
    Patent number: 9713637
    Abstract: The invention provides an isolated Bacillus cereus sensu lato strain, selected from Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis, in which the htrA gene or any part thereof is silenced, and vaccines comprising the same.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: July 25, 2017
    Assignee: State of Israel Prime Minister's Office Israel Institute for Biological Research
    Inventors: Ofer Cohen, Theodor Chitlaru, Avigdor Shafferman
  • BACILLUS ANTHRACIS HtrA-DEFECTIVE-DERIVED VACCINES
    Publication number: 20140170188
    Abstract: The invention provides an isolated Bacillus cereus sensu lato strain, selected from Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis, in which the htrA gene or any part thereof is silenced, and vaccines comprising the same.
    Type: Application
    Filed: July 18, 2012
    Publication date: June 19, 2014
    Applicant: STATE OF ISRAEL PRIME MINISTER'S OFFICE ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH
    Inventors: Ofer Cohen, Theodor Chitlaru, Avigdor Shafferman
  • Diagnosis of infection based on detection of bacterial secreted biomarkers
    Patent number: 8591899
    Abstract: A novel and rapid diagnostic method for anthrax infection is provided. Three B. anthracis gene products are described, as well as antibodies against the same, which may be used for the detection and monitoring of anthrax infection. Kits for the diagnosis of anthrax are also provided.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: November 26, 2013
    Assignee: State of Israel, Represented by Prime Minister's Office, Israel Institute for Biological Research
    Inventors: Avigdor Shafferman, Ofer Cohen, Theodor Chitlaru, Sagit Sela-Abramovich, Orit Gat
  • DIAGNOSIS OF BACILLUS ANTHRACIS INFECTION BASED ON DETECTION OF BACTERIAL SECRETED BIOMARKERS
    Publication number: 20120015379
    Abstract: A novel and rapid diagnostic method for anthrax infection is provided. Three B. anthracis gene products are described, as well as antibodies against the same, which may be used for the detection and monitoring of anthrax infection. Kits for the diagnosis of anthrax are also provided.
    Type: Application
    Filed: March 22, 2010
    Publication date: January 19, 2012
    Applicant: State of Israel, Represented by Prime Minister's Office
    Inventors: Avigdor Shafferman, Ofer Cohen, Theodor Chitlaru, Sagit Sela-Abramovich, Orit Gat
  • Uses of chemically-modified cholinesterases for detoxification of organophosporus compounds
    Patent number: 7572764
    Abstract: A circulatory long-lived cholinesterase (ChE) protein, such as acetylcholinesterase (AChE) or butyrylcholinesterase (BChE), which is a ChE protein modified with a non-antigenic polymer. The ChE may be AChE, such as native AChE of mammalian origin or of non-mammalian origin, or recombinant AChE. The recombinant AChE may be mutated at one or more amino-acid residues. The BChE may be native BChE of mammalian origin or of non-mammalian origin.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: August 11, 2009
    Assignee: State of Israel Prime Minister's Office Israel Institute for Biological Research
    Inventors: Ofer Cohen, Chanoch Kronman, Theodor Chitlaru, Baruch Velan, Avigdor Shafferman
  • Uses of chemically-modified cholinesterases for detoxification of organophosporus compounds
    Publication number: 20040147002
    Abstract: A circulatory long-lived cholinesterase (ChE) protein, such as acetylcholinesterase (AChE) or butyrylcholinesterase (BChE), which is a ChE protein modified with a non-antigenic polymer. The ChE may be AChE, such as native AChE of mammalian origin or of non-mammalian origin, or recombinant AChE. The recombinant AChE may be mutated at one or more amino-acid residues. The BChE may be native BChE of mammalian origin or of non-mammalian origin.
    Type: Application
    Filed: February 4, 2004
    Publication date: July 29, 2004
    Inventors: Ofer Cohen, Chanoch Kronman, Theodor Chitlaru, Baruch Velan, Avigdor Shafferman