Patents by Inventor Theodora Calogeropoulou
Theodora Calogeropoulou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230365602Abstract: The compound 5-cyclopentadecylpentyl (2-(trimethylammonio)ethyl) phosphate and pharmaceutical compositions thereof are provided for use in the treatment of a protozoal disease in a mammal. A process is also provided for the efficient, large-scale production of said compound.Type: ApplicationFiled: September 21, 2021Publication date: November 16, 2023Applicant: QUADREL S.R.L.Inventors: Theodora Calogeropoulou, Kyriakos Prousis, Marina Roussaki, Georgios Magoulas, Theano Fotopoulou
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Patent number: 9777037Abstract: The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).Type: GrantFiled: June 17, 2008Date of Patent: October 3, 2017Assignee: BIONATURE E. A. LTD.Inventors: Achilleas Gravanis, Theodora Calogeropoulou, Elias Castanas, Andreas Margioris, Ioannis Charalambopoulos, Nikolaos Avlonitis, Vassilios Minas, Vasileia-Ismini Alexaki, Christos Tsatsanis, Michael N. Alexis, Eumorphia Remboutsika, Varvara Vergou, Constantinos Neophytou
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Publication number: 20130303500Abstract: The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the treatment of multidrug resistant neoplasia.Type: ApplicationFiled: July 29, 2011Publication date: November 14, 2013Applicant: Medexis S.A.Inventors: Konstantinos Alevizopoulos, Theodora Calogeropoulou
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Publication number: 20120238488Abstract: The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the treatment of multidrug resistant neoplasia.Type: ApplicationFiled: June 22, 2010Publication date: September 20, 2012Inventors: Konstantinos Alevizopoulos, Theodora Calogeropoulou, Christos Stournaras
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Publication number: 20120225852Abstract: This invention pertains to the use of steroid compounds including spirosteroid analogues in treating, preventing or ameliorating the symptoms of inflammatory conditions. The steroid compounds are useful for treating a range of inflammatory conditions, including, but not limited to asthma, lung inflammation, retinal inflammatory conditions, autoimmune diseases such as rheumatoid arthritis, diabetes type I, systemic lupus erythematosus, ulcerative colitis and inflammatory bowel diseases and myopathies, as well as multiple sclerosis. The active compounds are represented by Formula I: wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention.Type: ApplicationFiled: September 13, 2010Publication date: September 6, 2012Inventors: Vasiliki Panoutsakopoulou, Maria Angelakopoulou, Theodora Calogeropoulou, Achilleas Gravanis, Lakovos Lazaridis, Constantinos Neophytou
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Patent number: 8097752Abstract: Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these compounds. The compounds can be used for the treatment of protozoal diseases and especially leishmaniasis.Type: GrantFiled: October 29, 2003Date of Patent: January 17, 2012Assignee: MAKScientific, LLCInventors: Theodora Calogeropoulou, Maria Koufaki, Nikolaos Avlonitis, Alexandros Makriyannis
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Publication number: 20100234335Abstract: The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).Type: ApplicationFiled: June 17, 2008Publication date: September 16, 2010Applicant: BIONATURE E. A. LTD.Inventors: Achilleas Gravanis, Theodora Calogeropoulou, Elias Castanas, Andreas Margioris, Ioannis Charalambopoulos, Nikolaos Avlonitis, Vassilios Minas, Vasileia-Ismini Alexaki, Christos Tsatsanis, Michael N. Alexis, Eumorphia Remboutsika, Varvara Vergou, Constantinos Neophytou
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Patent number: 7115657Abstract: The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should preferentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals.Type: GrantFiled: July 4, 2001Date of Patent: October 3, 2006Assignee: Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.Inventors: Maria Koufaki, Theodora Calogeropoulou, Alexandros Makriyannis
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Patent number: 7064116Abstract: The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatment of stress, anxiety, PMS, PND, and seizures such as those caused by epilepsy, to ameliorate or prevent the attacks of anxiety, muscle tension, and depression common with patients suffering from central nervous system abnormalities. The present invention comprises a compound represented by Formula (I): wherein, R, R1, R2, R3, R4, R5 are defined in the description of the invention. The present invention also includes formulations which consist of one or more of the compounds of Formula (I).Type: GrantFiled: December 21, 2001Date of Patent: June 20, 2006Inventors: Theodora Calogeropoulou, Andrew Tsotinis, Charikleia Souli, Alexandros Makriyannis
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Publication number: 20060105998Abstract: Disclosed are novel ring containing phospholipids represented by the structural formula A-X—PO3—W and physiologically acceptable salts thereof and a process for the preparation of these compounds. The compounds can be used for the treatment of protozoal diseases and especially leishmaniasis.Type: ApplicationFiled: October 29, 2003Publication date: May 18, 2006Applicant: MAK Scientific CorporationInventors: Theodora Calogeropoulou, Maria Koufaki, Nikolaos Avlonitis, Alexandros Makriyannis
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Publication number: 20050176976Abstract: The present invention relates to novel steroid derivatives that ace on the gamma-aminobutyric acid receptor-chloride ionophore (GR) complex as well as methods for making the same and their applications to induce anesthesia, in the treatment of stress, anxiety, PMS, PND, and seizures such as those caused by epilepsy, to ameliorate or prevent the attacks of anxiety, muscle tension, and depression common with patients suffering from central nervous system abnormalities. The present invention comprises a compound represented by Formula (I): wherein, R, R1, R2, R3, R4, R5 are defined in the description of the invention. The present invention also includes formulations which consist of one or more of the compounds of Formula (I).Type: ApplicationFiled: December 21, 2001Publication date: August 11, 2005Inventors: Theodora Calogeropoulou, Andrew Tsotinis, Charikleia Souli, Alexandros Makriyannis
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Publication number: 20040259763Abstract: The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should prefrentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals. The present invention comprises compounds represented by Formula (I), wherein R1, R2, R3, R4, R5 are further defined.Type: ApplicationFiled: January 9, 2003Publication date: December 23, 2004Inventors: Maria Koufaki, Theodora Calogeropoulou, Alexandros Makriyannis