Patents by Inventor Theodore Carver

Theodore Carver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for cytoprotection through mdm2 and hdm2 inhibition
    Publication number: 20060189511
    Abstract: The present invention is directed to a method of protecting one or more cells from programmed cytotoxic cell death by contacting the cells with a cytoprotective amount of an MDM2 and/or HDM2 inhibitor. The cytoprotective amount of inhibitor is typically used as a pulsed administration. Useful inhibitors include a class of 1,4-benzodiazepines, which act as inhibitors of MDM2-p53 interactions. The method of the invention can be employed as an adjunct to chemotherapy or radiation therapy. In addition, the methods of the invention can be employed to treat a disease or condition that involves excessive cell death.
    Type: Application
    Filed: May 13, 2003
    Publication date: August 24, 2006
    Inventors: Holly Koblish, Carl Manthey, Christopher Molly, Tianbao Lu, Daniel Parks, Louis Lafrance, Karen Milkiewicz, Theodore Carver, Bruce Grasberger
  • Substituted 1,4-benzodiazepines and uses thereof
    Publication number: 20060148792
    Abstract: The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions.
    Type: Application
    Filed: March 9, 2006
    Publication date: July 6, 2006
    Inventors: Tianbao Lu, Louis LaFrance, Daniel Parks, Karen Milkiewicz, Raul Calvo, Maxwell Cummings, Alexander Kim, Bruce Grasberger, Theodore Carver