Patents by Inventor Theodore I. Lidsky

Theodore I. Lidsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of central nervous system disorders associated with psychotic behavior and dementia with a combination of neuroleptic drugs and taurine, or derivatives thereof, to prevent the development of tardive dyskinesia
    Patent number: 5602150
    Abstract: The present invention relates to a method of treatment and a composition used to prevent the development of the adverse manifestation of tardive dyskinesia in individuals suffering from mental illness such as schizophrenia and undergoing treatment with neuroleptic or antipsychotic agents. The experimentally-based rationale for the present invention indicates that conventional neuroleptic drugs induce tardive dyskinesia because they evoke a glutamate afflux whose excitotoxic action is unopposed by other properties of these drugs, including dopamine receptor blockade. The present invention provides effective drug therapies for schizophrenia comprising conventional neuroleptics or antipsychotic drugs given in combination with taurine, a taurine precursor such as hypotaurine, taurine derivatives, or compounds similar in action to taurine, to render benign tardive dyskinesia as an adverse effect.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: February 11, 1997
    Assignee: Research Foundation for Mental Hygiene, Inc.
    Inventor: Theodore I. Lidsky