Patents by Inventor Theoharis V. Koftis

Theoharis V. Koftis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of O-desmethyl-venlafaxine and salts thereof
    Patent number: 8754261
    Abstract: The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV) and the pharmaceutically acceptable salts thereof, wherein it comprises (i) provision of spiro-venlafaxine compound as intermediate; (ii) conversion of spiro-venlafaxine intermediate into ODV free base in a one-pot process; and (iii) optionally conversion ODV free base into pharmaceutically acceptable salts. The present invention further relates to novel processes for the preparation of crystalline salts of ODV-succinate and ODV-oxalate.
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: June 17, 2014
    Assignee: Pharmathen S.A.
    Inventors: Theoharis V. Koftis, Ioanna Georgopoulou, Alexandros Strongilos, Fotini Liepouri, Theodoros Panagiotidis, Alexandra Lithadioti
  • Process for the preparation of a propenal intermediate and derivatives thereof
    Patent number: 8575343
    Abstract: The present invention provides an improved process for the preparation of (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methyl methanesulfon-amide, which is a useful intermediate for the preparation of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl methylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy hept-6-enoic acid, commonly known as Rosuvastatin.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: November 5, 2013
    Assignee: Pharmathen S.A.
    Inventors: Theoharis V. Koftis, Thanos Andreou, Aristotelis Menisiou, Efstratios Neokosmidis, Asteria Zitrou
  • PROCESS FOR THE PREPARATION OF PROPENAL INTERMEDIATE AND DERIVATIVES THEREOF
    Publication number: 20130066074
    Abstract: The present invention provides an improved process for the preparation of (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(3-oxoprop-1-enyl)pyrimidin-2-yl)-N-methyl methanesulfon-amide, which is a useful intermediate for the preparation of (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl methylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxy hept-6-enoic acid, commonly known as Rosuvastatin.
    Type: Application
    Filed: June 7, 2010
    Publication date: March 14, 2013
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Thanos Andreou, Aristotelis Menisiou, Efstratios Neokosmidis, Asteria Zitrou
  • PROCESS FOR THE PREPARATION OF MONTELUKAST AND SALTS THEREOF
    Publication number: 20120259121
    Abstract: The present invention relates to an improved process for the preparation of Montelukast and pharmaceutical acceptable salts or derivatives thereof, in particular to a process for large scale production of Montelukast and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds.
    Type: Application
    Filed: December 23, 2009
    Publication date: October 11, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Ravikant R. Soni
  • PROCESS FOR THE PREPARATION OF ROPINIROLE AND SALTS THEREOF
    Publication number: 20120253051
    Abstract: The present invention relates to an improved process for the preparation of Ropinirole and pharmaceutical acceptable salts or derivatives thereof, in particular to a process for large scale production of Ropinirole and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds.
    Type: Application
    Filed: December 16, 2009
    Publication date: October 4, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Ioanna Georgopoulou, Ravikant R. Soni, Panagiota Mandalou, Elli Alexandraki
  • PROCESS FOR THE PREPARATION OF O-DESMETHYL-VENLAFAXINE AND SALTS THEREOF
    Publication number: 20120253074
    Abstract: The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV) and the pharmaceutically acceptable salts thereof, wherein it comprises (i) provision of spiro-venlafaxine compound as intermediate; (ii) conversion of spiro-venlafaxine intermediate into ODV free base in a one-pot process; and (iii) optionally conversion ODV free base into pharmaceutically acceptable salts. The present invention further relates to novel processes for the preparation of crystalline salts of OD V-succinate and ODV-oxalate.
    Type: Application
    Filed: December 16, 2009
    Publication date: October 4, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Ioanna Georgopoulou, Alexandros Strongilos, Fotini Liepouri, Theodoros Panagiotidis, Alexandra Lithadioti
  • PROCESS FOR THE PREPARATION OF (R)-2-(3-DIISOPROPYLAMINO)-1-PHENYLPROPYL)-4METHYLPHENOL AND SALTS THEREOF
    Publication number: 20120041235
    Abstract: The present invention relates to an improved process for the preparation of Tolterodine or salts thereof, which comprises the use of 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl methane sulfonate.
    Type: Application
    Filed: February 17, 2009
    Publication date: February 16, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Efstratios Neokosmidis, Rohit Ravikant Soni, Panagiota Mandalou, Aristotelis Menisiou
  • PROCESS FOR THE PREPARATION OF FLUVASTATIN AND SALTS THEREOF
    Publication number: 20120035374
    Abstract: The present invention relates to an improved process for the preparation of fluvastatin or pharmaceutical acceptable salts or derivatives thereof, in particular to a one-pot process for large scale production of Fluvastatin and salts thereof in high yield and high purity and pharmaceutical preparations containing said compounds.
    Type: Application
    Filed: April 15, 2009
    Publication date: February 9, 2012
    Applicant: PHARMATHEN S.A.
    Inventors: Theoharis V. Koftis, Thoedoros Panagiotidis, Rohit Ravikant Soni, Alexandra Lithadioti