Patents by Inventor Thierry Kimmerlin

Thierry Kimmerlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE
    Publication number: 20220259212
    Abstract: The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in the treatment of inter alia cancer is disclosed.
    Type: Application
    Filed: July 10, 2020
    Publication date: August 18, 2022
    Inventors: Christoph BOSS, Sylvaine CREN, Thierry KIMMERLIN, Carina LOTZ-JENNE, Julien POTHIER, Naomi TIDTEN-LUKSCH
  • Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
    Patent number: 11267824
    Abstract: The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: March 8, 2022
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Christoph Boss, Daniel Bur, Sylvaine Cren, Thierry Kimmerlin, Carina Lotz-Jenne, Julien Pothier, Naomi Tidten-Luksch
  • INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE
    Publication number: 20200405696
    Abstract: The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia the treatment of cancer is disclosed.
    Type: Application
    Filed: January 14, 2019
    Publication date: December 31, 2020
    Inventors: Christoph BOSS, Sylvaine CREN, Thierry KIMMERLIN, Carina LOTZ-JENNE, Julien POTHIER, Naomi TIDTEN-LUKSCH
  • INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE
    Publication number: 20200216467
    Abstract: The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 9, 2020
    Inventors: Christoph BOSS, Daniel BUR, Sylvaine CREN, Thierry KIMMERLIN, Carina LOTZ-JENNE, Julien POTHIER, Naomi TIDTEN-LUKSCH
  • TRICYCLIC PIPERIDINE COMPOUNDS
    Publication number: 20180155344
    Abstract: The present invention relates to compounds of the formula (I) wherein R1a, R1b, R2, R3, (R4)n and ring (A) are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.
    Type: Application
    Filed: May 3, 2016
    Publication date: June 7, 2018
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: Daniel BUR, Corinna GRISOSTOMI, Thierry KIMMERLIN, Lubos REMEN, Hervé SIENDT, Magali VERCAUTEREN, Richard WELFORD
  • 8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives
    Patent number: 9951063
    Abstract: The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4 and R5 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: April 24, 2018
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Eva Caroff, Rémy Castro, Emmanuel Meyer, Thierry Kimmerlin
  • CXCR7 receptor modulators
    Patent number: 9920010
    Abstract: The present invention relates to derivatives of formula (I) wherein (R1)n, R2a, R2b, R3a, R3b, R4, L1, L2, X, Y and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: March 20, 2018
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Heinz Fretz, Philippe Guerry, Thierry Kimmerlin, Francois Lehembre, Julien Pothier, Hervé Siendt, Anja Valdenaire
  • Indole carboxamide derivatives as P2X7 receptor antagonist
    Patent number: 9718774
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: August 1, 2017
    Assignee: IDORSIA PHARMACEUTICALS LTD
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • Acrylamide derivatives as antimalarial agents
    Patent number: 9637473
    Abstract: The invention relates to novel acrylamide derivatives of the formula I wherein R1, R2, R3, X, and ring A are as defined in the description, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 2, 2017
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Hamed Aissaoui, Christoph Boss, Claire-Lise Ciana, Thierry Kimmerlin, Romain Siegrist
  • 8-(PIPERAZIN-1-YL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE DERIVATIVES
    Publication number: 20170107214
    Abstract: The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4 and R5 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.
    Type: Application
    Filed: March 23, 2015
    Publication date: April 20, 2017
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: Eva CAROFF, Rémy CASTRO, Emmanuel MEYER, Thierry KIMMERLIN
  • 1-[m-carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide derivatives
    Patent number: 9428456
    Abstract: The present invention relates to 1-[m-carboxamido(hetero)aryl-methyl]-heterocycyl-carboxamide compounds of formula (I) wherein X, Ar1, R1, R2, R3, R4, R5a, R5b and p are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: August 30, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD
    Inventors: Heinz Fretz, Markus Gude, Philippe Guerry, Thierry Kimmerlin, Francois Lehembre, Thomas Pfeifer, Anja Valdenaire
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9409917
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: August 9, 2016
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • CXCR7 RECEPTOR MODULATORS
    Publication number: 20160107997
    Abstract: The present invention relates to derivatives of formula (I) wherein (R1)n, R2a, R2b, R3a, R3b, R4, L1, L2, X, Y and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 21, 2016
    Inventors: Heinz FRETZ, Philippe GUERRY, Thierry KIMMERLIN, Francois LEHEMBRE, Julien POTHIER, Hervé SIENDT, Anja VALDENAIRE
  • 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
    Patent number: 9266876
    Abstract: The invention relates to compounds of Formula (I), wherein ring A, X, (R1)n, R2, R3, R4, R4?, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: February 23, 2016
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Eva Caroff, Marcel Keller, Thierry Kimmerlin, Emmanuel Meyer
  • NOVEL ACRYLAMIDE DERIVATIVES AS ANTIMALARIAL AGENTS
    Publication number: 20160024050
    Abstract: The invention relates to novel acrylamide derivatives of the formula (I) wherein R1, R2, R3, X, and ring A are as defined in the description, and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: Hamed AISSAOUI, Christoph BOSS, Claire-Lise CIANA, Thierry KIMMERLIN, Romain SIEGRIST
  • Heterocyclic amide derivatives as P2X7 receptor antagonists
    Patent number: 9221832
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 29, 2015
    Assignee: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm, Mark Murphy
  • 1-[m-Carboxamido(hetero)aryl-methyl]-heterocyclyl-carboxamide Derivatives
    Publication number: 20150336893
    Abstract: The present invention relates to 1-[m-carboxamido(hetero)aryl-methyl]-heterocycyl-carboxamide compounds of formula (I) wherein X, Ar1, R1, R2, R3, R4, R5a, R5b and p are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
    Type: Application
    Filed: June 21, 2013
    Publication date: November 26, 2015
    Inventors: Heinz FRETZ, Markus GUDE, Philippe GUERRY, Thierry KIMMERLIN, Francois LEHEMBRE, Thomas PFEIFER, Anja VALDENAIRE
  • INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST
    Publication number: 20150322008
    Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: December 11, 2013
    Publication date: November 12, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD
    Inventors: KURT HILPERT, FRANCIS HUBLER, THIERRY KIMMERLIN, DORTE RENNEBERG, SIMON STAMM
  • HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
    Publication number: 20150025075
    Abstract: The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
    Type: Application
    Filed: January 18, 2013
    Publication date: January 22, 2015
    Applicant: ACTELION PHARMACEUTICALS LTD.
    Inventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
  • 4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives
    Publication number: 20140371204
    Abstract: The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4?, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.
    Type: Application
    Filed: February 1, 2013
    Publication date: December 18, 2014
    Inventors: Eva Caroff, Marcel Keller, Thierry Kimmerlin, Emmanuel Meyer