Abstract: A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.

Abstract: The invention is based on the discovery of a new bacterial compound with analgesic properties which could be used as a new tool for the treatment of pain disorders such as visceral pain. Studying the mechanisms implicated in analgesic properties of the probiotic Escherichia coli strain Nissle 1917 (EcN), inventors characterized, the amino fatty acids produced by EcN, which display the Ecn analgesic properties. One of these compounds inhibits the hypersensitivity to colorectal distension induced by capsaicin, which is a very powerful nociceptive compound and acts via the GABA B receptor. Furthermore, inventors demonstrate that this compound is able to cross the cellular epithelial barrier (such as the intestinal epithelium). Thus, the invention relates to a lipopetide compound, derived from gamma-aminobutyric acid. The invention also relates to a lipopeptide compound according to the invention for the treatment of treating pain disorder, such as somatic pain and visceral pain.

Abstract: There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system comprises, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive comprising a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device comprises a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.

Abstract: There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system includes, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive including a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device includes a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.

Abstract: There is described a patch pump comprising a cartridge, a power source, a pump system, a drug delivery device and a control system configured to operate in particular the pump system and the drug delivery device. The pump system comprises, on the one hand, a pump having a pump housing containing a pump piston and a valve piston and, on the other hand, a pump drive comprising a piston motor and a valve motor for driving the pump piston and the valve piston independently from each other through a first and a second transmission. The drug delivery device comprises a transdermal delivery system having a needle actuation mechanism configured for transdermal insertion of a cannula.

Abstract: A provided method provides an assessment of quality of user experience during the loading, on a client, of a web page from a remote server via a network, according to the http protocol, the web page having a root file and at least one reference to a resource, including: a first step including identifying and timestamping the loading of a root file by the client; and a second step including: a step of identifying and timestamping the loading, by the client, of a resource assigned to the root file, a step of processing the timestamps to determine a relative load time of the resource corresponding to the period between the start time of the root file loading and the end time of the loading of the resource assigned to the root file; a step of analysis assessing the user experience in which the relative resource load time is an index.

Abstract: A method of measuring traversal time at a point of a network when setting up TCP (Transmission Control Protocol) connections, using recordings carried out according to a network protocol used to collect information on IP traffic, such as Netflow, the recordings including (i) a first recording generated by the synchronization request/response at this point of the network and (ii) the use of a field relating to a start instant (“StartTime”) of the first recording so as to date-stamp the synchronization request/response at this point of the network.

Abstract: A nacelle for a turbojet includes an air inlet structure capable of channeling an air flow toward a fan of the turbojet, a middle structure designed to surround the fan and a downstream section fitted with a pivoting-door thrust reverser system having a single thrust reverser door mounted so as to pivot between a closed position in which it allows an air flow to travel from the turbojet in a direct jet and in which it ensures the internal and external aerodynamic continuity of the nacelle and an open position in which it pivots toward a position substantially perpendicular to the axis of the nacelle, a downstream portion of the door moving inside the nacelle to close off at least a portion of the air flow of the turbojet and direct it in a direction oriented toward the front of the nacelle, where the downstream section has, downstream of the door, a ring extending over the whole periphery.

Abstract: A hydraulic control valve system comprising a hydraulic valve block with a plurality of control valve segments arranged in a juxtaposed manner, each control valve segment comprising a first line, for example a pump line, a second line, for example a return line, and a displaceable valve rod adapted to open and close the first line, respectively close and open the second line to varying degrees depending on a position of the valve rod. The valve system further has a plurality of actuators arranged in a juxtaposed manner, one actuator for each valve segment, each actuator comprising an electrical motor connected to a respective said valve rod through a coupling mechanism.

Abstract: A hydraulic control valve system comprising a hydraulic valve block with a plurality of control valve segments arranged in a juxtaposed manner, each control valve segment comprising a first line, for example a pump line, a second line, for example a return line, and a displaceable valve rod adapted to open and close the first line, respectively close and open the second line to varying degrees depending on a position of the valve rod. The valve system further has a plurality of actuators arranged in a juxtaposed manner, one actuator for each valve segment, each actuator comprising an electrical motor connected to a respective said valve rod through a coupling mechanism. Each motor has a rotor and a stator, whereby a ratio DS/HS of an average diameter DS of coils of the stator divided by an overall height HS of the coils in a direction parallel to an axis of rotation of the rotor is greater than four.

Abstract: A hydraulic control valve system comprising a hydraulic valve block with a plurality of control valve segments arranged in a juxtaposed manner, each control valve segment comprising a first line, for example a pump line, a second line, for example a return line, and a displaceable valve rod adapted to open and close the first line, respectively close and open the second line to varying degrees depending on a position of the valve rod. The valve system further has a plurality of actuators arranged in a juxtaposed manner, one actuator for each valve segment, each actuator comprising an electrical motor connected to a respective said valve rod through a coupling mechanism.

Abstract: The present invention describes novel methods, assays and kits for identifying and/or quantifying Aminoglycoside Binding Molecules (ABMs), enzymes modifying such molecules, and compounds modulating the interaction between ABMs and either enzymes or aminoglycosides, by exploiting the scintillation proximity effect. The invention, which makes use of aminoglycoside-coated scintillating supports, can be adapted to high throughput screening formats.

Abstract: The present invention describes novel methods, assays and kits for identifying and/or quantifying Aminoglycoside Binding Molecules (ABMs), enzymes modifying such molecules, and compounds modulating the interaction between ABMs and either enzymes or aminoglycosides, by exploiting the scintillation proximity effect. The invention, which makes use of aminoglycoside-coated scintillating supports, can be adapted to high throughput screening formats.

Abstract: The present invention relates to a fully edible feed body for domestic animals, comprising a central core having an elongated shape and a substantially circular or square section, to which at least one layer of a seed-based mixture is glued, and in which the central core is obtained by extrusion cooking from a mixture based on water, flour, seeds and optionally sugar.

Abstract: A food composition, particularly for pets, is prepared by adding and mixing cereal, vegetable protein, animal meal, vegetable by-products and lipid ingredients together and extrusion-cooking the mixture and then passing the extrusion-cooked mixture via a cone member and then a die member to obtain, from the die member, a product wherein a plurality of extrudate band layers form a lamellar structure, after which the lamellar-structure product is cut into pieces to obtain pieces which have a band layer lamellar structure, and then, the pieces are dried. The ingredients are employed and the process is carried out so that the dried product has a protein content of between 14% and 35%, a lipid content of between 2% and 20%, a carbohydrate content of at least 25%, a moisture content of between 2% and 15% and a density of between 0.3 and 0.6 g/cc.

Abstract: A food composition, particularly for pets, is prepared by adding and mixing cereal, vegetable protein extract, animal meal, vegetable by-products and lipid ingredients together and extrusion-cooking the mixture and then discharging the extrusion-cooked mixture via a die to obtain a plurality of extrudate bands and to form the bands into a lamellar structure product having a plurality of band layers, after which the lamellar structure is cut into pieces so that the pieces have a band layer lamellar structure and then, the pieces are dried. The ingredients are employed and the process is carried out so that the dried product has a protein content of between 14% and 35%, a lipid content of between 2% and 20%, a carbohydrate content of at least 25%, a moisture content of between 2% and 15% and a density of between 0.3 and 0.6 g/cc. The die has a die plate and a cone for forming the bands and layered structure.

Abstract: A process for the manufacture of cooked cereals or dry pet food which comprises preparing a mixture of water and a dry premix mainly comprising cereal flour or semolina, cooking the mixture and extruding it by pressing it through an extrusion die with the aid of a gear pump.

Abstract: A system for providing an emergency exit in a wall of an aircraft includes a pyrotechnic device disposed against the wall, and capable of cutting a desired opening in the wall, an igniter for the pyrotechnic device, a controller for the igniter, and a manometric safety device which receives the pressures inside and outside the aircraft and inhibits the action of the igniter when the difference between the pressures inside and outside the aircraft is greater than a predetermined value.