Abstract: Embodiments related to systems and methods for controlling the relative amounts of rotation and heave motions applied to a seat by an active seat suspension system are described.

Abstract: A method for identifying eye gestures of an eye includes the steps of emitting at least one laser beam onto the eye determining a single measuring sample having current values for: an optical path length of the emitted laser beam; a signal-to-noise ratio of radiation scattered back from the eye; an eye speed of the eye; and identifying an eye gesture based on the single measuring sample, wherein the optical path length is determined based on laser feedback interferometry of the emitted laser radiation with the radiation scattered back from the eye, and wherein the eye speed is determined based on a Doppler shift of the emitted radiation and the radiation scattered back, determined by means of the laser feedback interferometry.

Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.

Abstract: Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.

Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Abstract: Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo.

Abstract: A glasses device. The glasses device includes a frame structure for fixing the glasses device to a head of a user, at least one at least partially transparent vision element, which can be positioned in front of at least one eye of the user and through which the user can look, and at least one sensor arrangement arranged on the frame structure. The sensor arrangement is configured to capture sensor data while the user wears the glasses device. The sensor data at least partially represent at least one subarea of a body of the user during the wearing of the glasses device. A pose determination of a pose of the user can be carried out based on the sensor data.

Abstract: A method for operating a pair of smart glasses. The method includes a step of outputting a wavelength-modulated light beam by a light source to an eye of a user of the smart glasses, the light beam being output utilizing a movable mirror element in a state of rest. The method also includes a step of receiving a portion of the wavelength-modulated light beam, reflected from a reflection point, as reflection beam. The method further includes a step of ascertaining a wavelength difference between the reflection beam and the wavelength-modulated light beam, utilizing a laser feedback interferometry sensor. The method also includes a step of determining a distance d between the light source 135 and the reflection point, utilizing the wavelength difference.

Abstract: Aspects and implementations include systems and techniques that detect and correct failure of data storage and communication operations, including obtaining a first plurality of values, selecting a first plurality of error correction values to generate a first codeword, wherein the first codeword is associated with a plurality of syndrome values that encode a second subset of the first plurality of values, and causing a first processing device or a second processing device to restore the first plurality of values based on the first codeword.

Abstract: An asymmetric key cryptographic system is used to generate a cryptographic certificate for authenticating a memory module. This certificate is generated based on information, readable by the authenticator (e.g., host system), from at least one device on the memory module that is not read in order to obtain the certificate. For example, the certificate for authenticating a module may be stored in the nonvolatile memory of a serial presence detect device. The certificate itself, however, is based at least in part on information read from at least one other device on the memory module. Examples of this other device include a registering clock driver, DRAM device(s), and/or data buffer device(s). In an embodiment, the information read from a device (e.g., DRAM) may be based on one or more device fingerprint(s) derived from physical variations that occur naturally, and inevitably, during integrated circuit manufacturing.

Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Compounds of general formula (I): (I) wherein R1, R2, R3, R4, R5, Y and Z are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.

Abstract: A method comprises receiving a kernel used to convolve with an input tensor. For a first dimension of the kernel, a square block of values for each single dimensional vector of the kernel that includes all rotations of that single dimensional vector is generated. For each additional dimension of the kernel, group blocks of an immediately preceding dimension into sets of blocks, each set of blocks including blocks of the immediately preceding dimension that are aligned along a vector that is parallel to the axis of the dimension; and generate, for the additional dimension, one or more blocks of values, each block including all rotations of blocks within each of the sets of blocks of the immediately preceding dimension. The block of values corresponding to the last dimension in the additional dimensions of the kernel is output as the expanded kernel.

Abstract: Disclosed herein are novel lipids that can be used in combination with other lipid components, such as helper lipids, structural lipids, and cholesterols, to form lipid nanoparticles for delivery of therapeutic agents, such as nucleic acids (e.g., circular polynucleotides), both in vitro and in vivo.

Abstract: Dairy products are produced by subjecting a starting dairy material to nanofiltration to remove monovalent ions to produce an ion-depleted dairy permeate; passing the ion-depleted dairy permeate through an ion exchange column and subsequently with a sodium-containing eluting solution to produce sodium phosphate and sodium citrate derived from the starting material; concentrating the sodium phosphate and sodium citrate; and combining the concentrated sodium phosphate and sodium citrate with dairy components. The dairy product contains an amount of the concentrated sodium phosphate and sodium citrate sufficient to cause fat in the dairy product to be emulsified and protein in the dairy product to be hydrated. In addition or alternatively, a dairy by-product stream may be subjected to ion exchange to remove calcium therefrom; concentrated, and combined with dairy materials naturally containing phosphate and citrate in order to adjust the citrate+phosphate-to-calcium ratio to reach an emulsified dairy product.

Abstract: The present invention provides a testing substrate (W) for estimating stress in production substrates due to a substrate support, said testing substrate having a support surface (SS) divided into predefined portions, wherein the predefined portions comprise at least one first portion (1) having a first coefficient of friction being substantially uniform across the at least one first portion, and at least one second portion (2) having a second coefficient of friction being substantially uniform across the at least one second portion, wherein the second coefficient of friction is different to the first coefficient of friction. The present invention also provides a method for estimating stress in a substrate due to a substrate support and a system for making such an estimation.

Abstract: An optical arrangement of data smart glasses includes a first laser device configured to emit a projection light beam, a second laser device configured to emit a measuring light beam, a first scanner, a second scanner, and a beam combiner configured to bundle the projection light beam and the measuring light beam into a common light beam, wherein the first scanner is configured to deflect the projection light beam emitted by the first laser device in a first axis, and wherein the second scanner is configured to deflect the common light beam focused by the beam combiner in a second axis.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: An asset tracking system includes a tracking device associated with a mobile asset and a centralized device management platform. The tracking device is configured via a set of device configurations. The centralized device management platform includes one or more processors in communication with the tracking device and computer-readable memory encoded with instructions that, when executed, cause the system to receive location data corresponding to a location of the tracking device; evaluate the location data to identify a zone corresponding to a physical region that includes the location of the tracking device; compare an identified zone with a set of location-based rules to identify a rule associated with the identified zone; update the set of device configurations with a device configuration that is associated with an identified rule; and sync an updated set of device configurations to the tracking device to reconfigure the tracking device based on the identified rule.

Abstract: An asset tracking system includes a tracking device associated with a mobile asset and a centralized device management platform. The tracking device is configured via a set of device configurations. The centralized device management platform includes one or more processors in communication with the tracking device and computer-readable memory encoded with instructions that, when executed, cause the system to receive location data corresponding to a location of the tracking device; evaluate the location data to identify a zone corresponding to a physical region that includes the location of the tracking device; compare an identified zone with a set of location-based rules to identify a rule associated with the identified zone; update the set of device configurations with a device configuration that is associated with an identified rule; and sync an updated set of device configurations to the tracking device to reconfigure the tracking device based on the identified rule.