Abstract: The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.

Abstract: Described herein are systems, devices, methods, and media for transmitting emergency alerts, emergency services requests, and emergency data associated with emergency alerts and emergency service requests to relevant parties, such monitoring centers and emergency service providers.

Abstract: A filter assembly includes a filter housing, a filter housing lid, a filter cartridge, an endplate, and a seal member. The filter housing defines a first cavity and comprises a return passage in fluid communication with the first cavity. The filter housing lid is selectively coupled to the filter housing and defines a second cavity coextensive with the first cavity. The filter cartridge is positioned within the first cavity. The endplate is coupled to a first end of the filter cartridge. The endplate is configured to interface with the filter housing. The seal member is coupled to the endplate and is configured to be received in the return passage. The endplate is configured to partially separate the filter housing from the filter cartridge.

Abstract: A system for pumping and metering a fluid for a turbine engine, which system includes at least one pump for the fluid and an electronic computer configured to determine the flow rate of the fluid to be delivered to the turbine engine, the pumping and metering system being wherein it further includes a first electric motor and a second electric motor, which are each configured to drive the at least one pump, and in that the electronic computer includes a first control loop for controlling at least the first electric motor and a second control loop for controlling at least the second electric motor.

Abstract: A spark plug assembly includes a spark plug, where the spark plug includes a high voltage connector, an insulator body, a metallic shell, and an electrical conductor at least partly disposed in the insulator body and the metallic shell. The spark plug assembly includes a detection unit having a transmitter device and a receiver device. The transmitter device is coupled to the spark plug and is electrically disposed between the high voltage connector and the electrical conductor. Further, the transmitter device is configured to draw an excitation current from the electrical conductor. The transmitter device includes an optical signal generator that is configured to generate an optical signal in response to the drawn excitation current. The receiver device is disposed in optical communication with the transmitter device and configured to receive the optical signal from the transmitter device.

Abstract: A roll arrangement for producing a web of fibrous material which is compressed includes: a compression press, which includes at least one compression roll and a mating roll and is configured for compressing the web in a transverse direction which is transverse to a conveying direction of the web; and a tensioning belt, which is elastic and is configured for supporting the web and for being guided through a first nip between the at least one compression roll and the mating roll and over the at least one compression roll.

Abstract: A tracking device can use a permanent encryption key pair to encrypt one or more temporary encryption key pairs, which can then be provided to a central tracking system. When a community mobile device subsequently detects the tracking device, the central tracking system provides an encrypted temporary encryption key pair to the community mobile device. The community mobile device uses the encrypted temporary encryption key pair to encrypt location data representative of a location of the community mobile device, and provides the encrypted location data to the central tracking system. When a user subsequently requests a location of the tracking device from the central tracking system, the central tracking system provides the encrypted location data, and a device of the user can decrypt the encrypted temporary encryption key pair using the permanent encryption key pair, and can decrypt the location data using the decrypted temporary encryption key pair.

Abstract: Materials and methods for producing tactile anatomical structures are described. These are intended primarily for use for high-value, in-depth surgical training for novice or expert surgeons. They may also be used for medical education, sales demonstrations, or for research and development. Examples of embodiments refer to their use in knee and shoulder models. The tactile tissue-simulating structures include, amongst others: skin, fat, muscles, ligaments, tendons, cartilage, bursa, fat pad, and periosteum. A method for creating a musculotendinous junction is also described.

Abstract: A building system including one or more memory devices configured to store instructions that, when executed on one or more processors, cause the one or more processors to collect building device data of a building device, generate a time correlated data stream for a data point, and generate a time correlated reliability data stream for the data point. The building device data includes a plurality of data samples of the data point. The time correlated data stream includes values of the plurality of data samples of the data point. The time correlated reliability data stream includes a plurality of reliability values time correlated to corresponding values of the plurality of data samples of the data point and indicating reliability of the values of the plurality of data samples of the data point.

Abstract: Disclosed are compositions comprising NPN compound coated with a bypass agent allowing ruminal bypass of the composition and a method for increasing fiber digestibility, a method for increasing feed intake, a method for increasing somatic growth, a method for increasing milk production, a method for reducing N excretion in a ruminant, a method for improving rumen pH stability in a ruminant, a method for preventing or reducing ammonia toxicity in the rumen. The compositions and methods of the invention are particularly suitable for ruminants that are held in harsh climates and/or at remote locations from a farm.

Abstract: In one example in accordance with the present disclosure, a fluidic die is described. The fluidic die includes a substrate and fluid actuators, the fluid actuators being disposed on the substrate. The fluidic die also includes a bond pad region defined on the substrate. The bond pad region includes a high aspect ratio power delivery bond pad with multiple bonding sites and a high aspect ratio power return bond pad with multiple bonding sites.

Abstract: The present invention relates to a method of producing a polypeptide having ?-hexosaminidase activity, comprising the steps of a) providing a yeast cell comprising a polynucleotide encoding a polypeptide having ?-hexosaminidase activity and having an amino acid sequence being at least 95% identical to the amino acid sequence shown in SEQ ID NO: 1, b) cultivating said yeast cell under conditions which allow for the production of the polypeptide, and c) obtaining the polypeptide produced in step b). The present invention further concerns a polynucleotide encoding a polypeptide having ?-hexosaminidase activity and having an amino acid sequence being at least 95% identical to the amino acid sequence shown in SEQ ID NO: 1, as well as polypeptide encoded by said polynucleotide. Moreover, the present invention concerns a yeast cell comprising the polynucleotide of the present invention.

Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, agricultural compositions containing them and their use as herbicides wherein R1, R2, R3, R4, R14, and X are as defined in the disclosure, A is selected from and R12, R13, n, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, Y and Y1 are as defined in the disclosure.

Abstract: The present invention relates to the use of a CD91 polypeptide for detection and quantification of a hemopexin:heme complex in a biological sample, to the use of a CD91 polypeptide for separation of a hemopexin:heme complex from a biological sample and to the monitoring of a hemolysis treatment using a CD91 polypeptide.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Described are substrate containers that are useful for holding or transporting substrates such as semiconductor wafers and microelectronic devices, in a clean environment, as well as methods of using the substrate containers.