Abstract: The present disclosure is directed to fluoride (F) ion batteries and F shuttle batteries comprising an anode with a solid electrolyte interphase (SEI) layer, a cathode comprising a core shell structure, and a liquid fluoride battery electrolyte. According to some aspects, the components therein enable discharge and recharge at room-temperature.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Abstract: Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a receiver housing with a first internal volume and a second internal volume, a first diaphragm separating the first internal volume into a first front volume and a first back volume such that the first front volume has a first sound outlet port, a second diaphragm separating the second internal volume into a second front volume and a second back volume such that the second front volume has a second sound outlet port, a motor disposed at least partially inside the housing such that the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm, an acoustic seal between the first front volume and the second back volume such that the acoustic seal accommodates the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm.

Abstract: Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein.

Abstract: An airframe design may include a bonded frame or assembly, and one or more components that may be removably attached to the bonded frame. The bonded frame may include struts, central bulkheads, a tail section, a plurality of wing sections, and motor mounts that are adhered together using adhesive. The one or more attachable components may include a forward fuselage, motors, propellers, motor pod fairings, stabilizer fins, and landing gear that are attached using fasteners. The bonded frame may reduce the number of parts of the airframe design and may also reduce complexity, cost, and weight, while also increasing stiffness and strength. Further, the various attachable components may facilitate fabrication, assembly, and maintenance of an aerial vehicle having the airframe design.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.

Abstract: An acoustic receiver includes a first receiver subassembly having bottom housing plate with at least a portion of a motor fastened thereto, and a second receiver subassembly having a closed-ended housing wall with at least one open end that is fastened to the bottom housing plate. A method of making and assembling the components is also described.

Abstract: Methods and systems for implementing artificial intelligence enabled metrology are disclosed. An example method includes segmenting a first image of structure into one or more classes to form an at least partially segmented image, associating at least one class of the at least partially segmented image with a second image, and performing metrology on the second image based on the association with at least one class of the at least partially segmented image.

Abstract: Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a receiver housing with a first internal volume and a second internal volume, a first diaphragm separating the first internal volume into a first front volume and a first back volume such that the first front volume has a first sound outlet port, a second diaphragm separating the second internal volume into a second front volume and a second back volume such that the second front volume has a second sound outlet port, a motor disposed at least partially inside the housing such that the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm, an acoustic seal between the first front volume and the second back volume such that the acoustic seal accommodates the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm.

Abstract: The present disclosure relates to a balanced armature receiver diaphragm including a paddle (202) flexibly coupled to a frame (204) and spaced apart therefrom by a gap (206). The paddle comprises a material having a specific modulus kg/m3) in at least one direction and density selected to increase stiffness and reduce mass. In one implementation, at least the paddle includes a carbon fiber material. The resulting paddle has improved acoustic performance including improved frequency response and less resonance in the audio band, among other benefits.

Abstract: Methods and systems for governing execution of a geography dependent computer process are provided. In one aspect, a method includes receiving a target location comprising a geographic identifier. The method also includes accessing a data store comprising a plurality of maps. Each map of the plurality of maps includes a plurality of geometric shapes and each geometric shape is associated with an execution rule. The method also includes determining which geometric shape of the plurality of geometric shapes the geographic identifier is bounded within for at least two maps of the plurality of maps. The method further includes generating an aggregate rule set based on each execution rule associated with each geometric shape determined to bound the geographic identifier. The method further includes applying the aggregate rule set. Machine-readable media are also provided.

Abstract: A system accesses a three-dimensional map of a geographic region and generates a two-dimensional projection of the road based on the three-dimensional map. The two-dimensional projection comprises a plurality of points along the road and each point is assigned a score measuring a navigability of the point. Based on the navigability score of each point and history of vehicle positions on the road, the system identifies a plurality of navigable points on the two-dimensional projection of the road. Based on the plurality of navigable points, the system determines a navigable surface corresponding to a physical area over which a vehicle may safely navigate and navigable surface boundaries surrounding that area. The navigable surface area and boundaries on the two-dimensional projection are converted into a three-dimensional representation, which the system uses to generate an updated three-dimensional map of the geographic region.

Abstract: The subject technology provides for visualizing a route traversed by a user during a movement event by periodically obtaining position information data from a receiver of a navigation system during a movement event. A path traversed by a user of a device that includes the receiver during the movement event is estimated based on the position information data. One or more previously mapped features within a proximity of the estimated path on a map are determined. The estimated path is matched to the map based on the previously mapped features to obtain a map-matched path. A display device is caused to render the map-matched path on an image of the map.

Abstract: An advance pairing system preemptively pairs a phone to a vehicle using a backend cloud system prior to establishing the connection with the vehicle, such as during the time that a user is purchasing a vehicle, or just after the user enters the vehicle for the first time. The system includes a mobile application for automated advance pairing with the vehicle's automotive computer. The mobile app sends a request for advance pairing to a server that assigns a set of unique keys to the account for secure pairing of the mobile device and the vehicle. The server pushes an encrypted payload to both the mobile device app and the vehicle advance pairing app operating on the automotive computer. The encrypted payload can include a unique vehicle ID, a unique mobile device ID, and one or more encryption keys. The mobile device and the vehicle use the encrypted advance pairing information to establish a secured connection with minimal user input.

Abstract: Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

Abstract: A beverage container rimmer is provided. A beverage container rimmer device for applying garnish to an outer rim of a beverage container, the beverage container rimmer comprising an inner compartment surrounded by a first compartment and a second compartment. The first compartment housing a liquid garnish and employing a first application member for applying the liquid garnish to the outer rim of the beverage container. The second compartment housing a granular garnish and employing a second application member for applying the granular garnish to the outer rim of the beverage container.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.