Abstract: In one embodiment, a method includes obtaining a target template and processing the target template to identify at least one component of the target template. The method also includes searching at least one collection of content to identify at least a first instance of content that substantially matches the component of the target template. The first instance of content is presented as substantially matching the component. Finally, a first arrangement that includes the first instance of content is created. Such a first arrangement is associated with a mash-up related to the target template.

Abstract: In one embodiment, a method comprises registering content providers, each content provider having a corresponding independent moderation policy configured for selectively providing network access to a media content item supplied by a user; receiving, from a first of the content providers, a first notification that a first media content item has been moderated by the first content provider; and sending a second notification to at least a second of the content providers, the second notification identifying that the first content provider has moderated the first media content item, the second notification enabling the second content provider to moderate the first media content item based on the second notification and according to the corresponding independent moderation policy of the second content provider.

Abstract: In one embodiment, a method includes establishing a session by associating at least a first party with the session. The first party is associated with a first device, and is associated with the session through the first device. The method also includes defining an effective user to include the first party, tracking actions taken with respect to the session by the effective user, and attributing the actions taken with respect to the session by the effective user to the first party and to the effective user.

Abstract: In one embodiment, a method comprises registering content providers, each content provider having a corresponding independent moderation policy configured for selectively providing network access to a media content item supplied by a user; receiving, from a first of the content providers, a first notification that a first media content item has been moderated by the first content provider; and sending a second notification to at least a second of the content providers, the second notification identifying that the first content provider has moderated the first media content item, the second notification enabling the second content provider to moderate the first media content item based on the second notification and according to the corresponding independent moderation policy of the second content provider.

Abstract: In one embodiment, a method includes obtaining a target template and processing the target template to identify at least one component of the target template. The method also includes searching at least one collection of content to identify at least a first instance of content that substantially matches the component of the target template. The first instance of content is presented as substantially matching the component. Finally, a first arrangement that includes the first instance of content is created. Such a first arrangement is associated with a mash-up related to the target template.

Abstract: In one embodiment, a method comprises identifying, by a device, an addressable media stream selected for presentation by a user; identifying, by the device, a user input that is input by the user during presentation of the addressable media stream to the user, the user input identified relative to an identified position within the addressable media stream; defining by the device a media clip from the addressable media stream based on determining the user input demonstrates a favorable affinity by the user toward the identified position, the defining including the device selecting a media clip start position within the addressable media stream and that precedes the identified position, and the device selecting a media clip end position that follows the identified position; and creating by the device a summary media clip of the addressable media stream that includes at least the media clip.

Abstract: In one embodiment, a method comprises collecting, by a server from a user device, a comment input by a user into the user device, the collecting including identifying a time that the user generated the comment; associating, by the server, the comment input by the user with an identifiable addressable media stream and at an identified position within the addressable media stream that is coincident with the time that the user generated the comment relative to an event presented in the addressable media stream; and generating and outputting by the server a media comment message that identifies the user, the comment generated by the user, the addressable media stream and the identified position within the addressable media stream coinciding with the time that the user generated the comment.

Abstract: Metalloproteinase inhibitors are provided which are selective inhibitors of the action of gelatinase, and may be of use in the treatment of cancer to control the development of tumour metastases.

Abstract: Triaza macrocycles carrying a -CH.sub.2 COOH, -CH.sub.2 CONR.sup.6 R.sup.7, --CH.sub.2 P(R.sup.5)O.sub.2 H, or --CH.sub.2 PO.sub.3 H.sub.2 group on two of the three ring nitrogen atoms and a --CH(L--Z)COOH, --CH(L--Z)CONR.sup.6 R.sup.7, --CH(L--Z)P(R.sup.5)O.sub.2 H, or --CH(L--Z)PO.sub.3 H.sub.2 group on the third ring nitrogen atom, in which L is an organic linking radical and Z is any group capable of reacting with a thiol, amino, carboxy, hydroxyl, aldehyde, aromatic, or heteroaromatic group, and metal complexes thereof, are useful for imaging, diagnosis, and therapy. A typical embodiment is N-[5-carboxy-5-{4,7-bis-(carboxymethyl)-1,4,7-triazacyclonon-1-yl}pentyl] 3-maleimidopropionamide.

Abstract: Compounds of formula (1) are described wherein R represents a --CONHOH, carboxyl, carboxyl ester, or --P(O)(X.sup.1 R.sup.8)X.sup.2 R.sup.9, where X.sup.1 and X.sup.2 are the same or different and each is oxygen or sulphur, R.sup.8 and R.sup.9 are the same or different and each represents hydrogen or an optionally substituted alkyl, aryl or aralkylthioalkyl group; R.sup.2 represents an optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkoxy, or aralkylthio group, or an amino, substituted amino, carboxyl, or carboxyl ester group; R.sup.3 represents hydrogen or alkyl; R.sup.4 represents hydrogen or alkyl; R.sup.5 represents an optionally substituted alkyl or alkenyl group optionally interrupted by one or more --O-- or --S-- atoms or --N(R.sup.7)-- groups, where R.sup.7 is a hydrogen atom or a C.sub.1-6 alkyl group, or --(Alk).sub.n R.sup.6 where Alk is an alkyl or alkenyl group optionally interrupted by one or more --O-- or --S-- atoms or --N(R.sup.

Abstract: Ti-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, --CO.sub.2 H, --SO.sub.3 H, PO.sub.3 H.sub.2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.

Abstract: A compound of formula (I): ##STR1## wherein R represents a --CONHOH, carboxyl (--CO.sub.2 H) or esterified carboxyl group;X represents an amino (--NH.sub.2), or substituted amino, hydroxyl or substituted hydroxyl group; and their use as metalloproteinase inhibitors.

Abstract: The conjugation of antibodies to a macrocyclic conjugate compound wherein the conjugate compound has the structure (I), wherein R.sup.1 is --(CH.sub.2).sub.p --R.sup.6 --CH.sub.2).sub.q -- where p and q are the same or different and are 0, 1 or 2, and --R.sup.6 -- is --((CH.sub.2).sub.n --, where n is 0 or 1, --NH--, --O--, --S-- or (II), R.sup.1 optionally being alkyl substituted, provided that neither p nor q is 0 unless R.sup.6 is --CH.sub.2 --; R.sup.2 are --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 --, optionally alkyl, alkoxyalkyl or hydroxyalkyl substituted; R.sup.3 are the same or different and are --H, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, carboxyalkyl ester, phosphate, sulphonate or phosphonate; R.sup.4 is one of the compounds of formula (III) optionally alkyl substituted, wherein R.sup.7 is --H, alkyl, hydroxyalkyl, or alkoxyalkyl provided that when R.sup.4 is (III d), R.sup.3 is not carboxyalkyl, R.sup.5 is a linker, and Ab is an antibody.

Abstract: Tri-aza macrocycles of formula (I), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, --CO.sub.2 H, ---SO.sub.3 H, PO.sub.3 H.sub.2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.

Abstract: A conjugate compound has the structure (I), wherein R.sup.1 is --(CH.sub.2).sub.p --R.sup.6 --(CH.sub.2).sub.q -- where p and q are the same or different and are 0, 1 or 2, and --R.sup.6 -- is --(CH.sub.2).sub.n --, where n is 0 or 1, --NH--, --O--, --S-- or (II), R.sup.1 optionally being alkyl substituted, provided that neither p nor q is 0 unless R.sup.6 is --CH.sub.2 --; R.sup.2 are --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 --, optionally alkyl, alkoxyalkyl or hydroxyalkyl substituted; R.sup.3 are the same or different and are --H, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, carboxyalkyl ester, phosphate, sulphonate or phosphonate; R.sup.4 is one of the compounds of formula (III) optionally alkyl substituted, wherein R.sup.7 is --H, alkyl, hydroxyalkyl, or alkoxyalkyl provided that when R.sup.4 is (III d), R.sup.3 is not carboxyalkyl, R.sup.5 is a linker, and Ab is an antibody.

Abstract: Cross-linking reagents which are highly specific for sulphydryl groups and react with thiols at an excellent rate. The essential feature of the reagents is at least one vinyl group conjugated with an armoatic nitrogen heterocycle. Particular examples include vinyl pyridines, vinyl pyrimidines and vinyl triazines.