Abstract: Provided are methods for the use of belvarafenib to treat brain cancer including metastatic brain cancer carrying a BRAF mutation, a NRAS mutation, a KRAS mutation, or a combination thereof.

Abstract: A silicone-polyolefin composition is disclosed. The silicone-polyolefin composition comprises (A) a polysiloxane, (B) a functionalized polyolefin, and (C) a curable silicone elastomer component. The polysiloxane (A) comprises an average of at least one functional group X per molecule, and the functionalized polyolefin (B) comprises an average of at least one functional group Y per molecule, where the functional group X and functional group Y are reactable to form a bond therebetween. A silicone-polyolefin blend, a curable composition comprising the silicone-polyolefin blend, a cured product of the curable composition, and methods of preparing the silicone-polyolefin blend, curable composition, and cured product are also disclosed.

Abstract: The present disclosure relates to curable silicone elastomer compositions having enhanced adhesive properties with respect to a wide variety of substrates (hereafter referred to as “curable silicone elastomer compositions”). Elastomers made by curing the curable silicone elastomer compositions may be adhered to a wide variety of substrates to form composites comprising the elastomers and the substrates. Processes for adhering the elastomers made by curing the curable silicone elastomer compositions to the substrates are also provided. An adhesion promoter, component (D), is provided to enhance adhesion. Component (D) is a polyorganosiloxane having (i) at least one unsaturated group per molecule selected from alkenyl groups and alkynyl groups and (ii) an anhydride functionality and an aromatic functionality, wherein a carbon of the aromatic functionality is separated from a carbon of a carbonyl group of the anhydride by a carbon chain of from 1 to 3 non-aromatic carbon atoms inclusive.

Abstract: A flowable silicone-polyolefin composition is disclosed. The silicone-polyolefin composition comprises (A) a polysiloxane and (B) a functionalized polyolefin dispersed in the polysiloxane (A). The polysiloxane (A) comprises an average per molecule of at least one functional group X, and the functionalized polyolefin (B) comprises an average per molecule of at least one functional group Y that is reactable with the functional group X of the polysiloxane (A) to form a bond therebetween. A curable composition comprising the flowable silicone-polyolefin composition, a cured product of the curable composition, and methods of preparing the flowable silicone-polyolefin composition, curable composition, and cured product are also disclosed.

Abstract: An aircraft is disclosed with a fuselage including a cabin delimited by a cabin floor and having crew quarters. The crew quarters include an upper portion above a floor plane defined by the cabin floor and a lower portion beneath the floor plane. The crew quarters include a seat adjustable between a sitting configuration and a berthing configuration. A method of transitioning a crew member of an aircraft to a berthing configuration in a crew quarters is also disclosed.

Abstract: Aircraft pitch control systems and methods are disclosed. In one exemplary embodiment, an aircraft pitch control system comprises a movable horizontal stabilizer and an elevator movably coupled to the horizontal stabilizer. The elevator is electronically geared to the horizontal stabilizer.

Abstract: Aircraft pitch control systems and methods are disclosed. An aircraft pitch control system (28) comprises a movable horizontal stabilizer (24) and an elevator (26) movably coupled to the horizontal stabilizer. The elevator is electronically geared to the horizontal stabilizer.

Abstract: Aircraft pitch control systems and methods are disclosed. An aircraft pitch control system (28) comprises a movable horizontal stabilizer (24) and an elevator (26) movably coupled to the horizontal stabilizer. The elevator is electronically geared to the horizontal stabilizer.

Abstract: The present disclosure provides methods and system for controlling the operation of an aircraft aileron which comprises an inboard portion and an outboard portion. A velocity of the aircraft is determined. Then, based on the velocity of the aircraft, the aileron is caused to move in certain ways. Below a first velocity threshold, the inboard aileron portion and the outboard aileron portion are caused to move substantially in unison. Between the first velocity threshold and a second, greater, velocity threshold, the outboard portion of the aileron is caused to lock and the inboard portion of the aileron is caused to move independently from the outboard portion. Above the second velocity threshold, the inboard portion is caused to move substantially opposite from the outboard portion.

Abstract: An aircraft is disclosed with a fuselage including a cabin delimited by a cabin floor and having crew quarters. The crew quarters include an upper portion above a floor plane defined by the cabin floor and a lower portion beneath the floor plane. The crew quarters include a seat adjustable between a sitting configuration and a berthing configuration. A method of transitioning a crew member of an aircraft to a berthing configuration in a crew quarters is also disclosed.

Abstract: The present disclosure provides methods and system for controlling the operation of an aircraft aileron which comprises an inboard portion and an outboard portion. A velocity of the aircraft is determined. Then, based on the velocity of the aircraft, the aileron is caused to move in certain ways. Below a first velocity threshold, the inboard aileron portion and the outboard aileron portion are caused to move substantially in unison. Between the first velocity threshold and a second, greater, velocity threshold, the outboard portion of the aileron is caused to lock and the inboard portion of the aileron is caused to move independently from the outboard portion. Above the second velocity threshold, the inboard portion is caused to move substantially opposite from the outboard portion.

Abstract: A system for providing interactive content for thin applications executing on client devices, the system including: a computer processor; a content provider configured to: receive a content request; and provide content for a thin application executing on a client device in response to the content request; and a content engine executing on the computer processor to enable the computer processor to: receive a content instruction request; provide a content instruction set defining a set of client-interactive controls corresponding to a specific content for the thin application, where: the content instruction set identifies a set of images; the content instruction set includes instructions for indicating which of the set of images to display based on a current image of the set of images and a detected user input; and the content is displayed by the thin application in association with at least one of the set of images.

Abstract: A method for providing and displaying advertising content. The method can include: sending, by a client device, a request for advertisement content; receiving, by the client device and in response to the request, an advertisement instruction set defining a plurality of client-interactive controls, the advertisement instruction set identifying a plurality of images, each of the plurality of images comprising an indication of at least one of the plurality of client-interactive controls; detecting a set of user inputs each associated with at least one of the plurality of client-interactive controls; identifying, by the client device and in response to each user input of the set of user inputs, an image of the plurality of images based on a current image displayed by the client device and the client-interactive control associated with the user input; and displaying the image by the client device.