Abstract: The invention relates to an implantable, vascular support system (10) having a cannula (13) and an ultrasound measuring device (18), wherein the cannula (13) and the ultrasound measuring device (18) are disposed in the region of mutually opposite ends of the support system (10).

Abstract: A secure data fabric (SDF) can include a security platform for sharing data, access and discovery of data, and audit traceability, across disparate data stores and networks. A SDF can leverage blockchain with attribute-based access control (ABAC). A SDF platform can include an immutable data storage medium, a data sharing node, a central processing unit, and memory having software, which can be configured to implement a blockchain and an ABAC module. The immutable data storage medium can be part of a network. The immutable data storage medium can be immutable off-chain data storage for the SDF, and a multi-layered ABAC security policy can be implemented for the SDF. The SDF can have a cross-domain topology model. A multi-party workflow for account keys and digital signatures management can be further implemented. A microservices-based access control module can be configured to dynamically evaluate digital security policies for a secure data fabric.

Abstract: A waveguide structure for a head up display in which a reflective output coupling structure is formed of a separate, but connected, component to a main waveguide. Light is coupled from the main waveguide to the output coupling structure by evanescent wave coupling. In a method of manufacture for such a waveguide the output coupling structure is attached to the main waveguide using an optical feedback technique.

Abstract: A four-sided stacking display case with multiple sections that can be easily assembled and disassembled. The top section has a uniform bottom attachment, the middle sections have a uniform top attachment and a uniform bottom attachment, and the bottom section has a uniform top attachment. All uniform top attachments are the same and consist of four panels attached in an offset cross pattern where each panel has a groove, and all uniform bottom attachments are the same and consist of four panels attached in an offset cross pattern where each panel has a protruding tongue, where the four tongues insert into and attach to the four grooves, so that the sections are easily attached or detached.

Abstract: A cardiac support system (20) is equipped with a retaining structure (30) for the cardiac support system, said retaining structure (30) being intended to fix the cardiac support system in place. The cardiac support system comprises a device for monitoring the integrity of the retaining structure (30).

Abstract: The invention relates to an implantable device (1) for determining a fluid volume flow (2) through a blood vessel (3), comprising: —at least one sensor (4) for recording at least one flow parameter, —a retaining means (5) for retaining a vessel wall port (6) in the region of a vessel wall (7) of the blood vessel (3), wherein the retaining means (5) is formed to retain the at least one sensor (4) in the region of the vessel wall (7).

Abstract: The invention relates to a device (105) for determining a cardiac output for a cardiac assist system (100), wherein the device (105) comprises a support structure (115) and a sensor device (120). The support structure (115) comprises at least one brace (125) and a connection section (130) for connecting the device (105) to an element (110, 112) of the cardiac assist system (100). The at least one brace (125) is connected to the connection section (130) and can be folded away from the element (110, 112). The sensor device (120) is coupled to the at least one brace (125) and configured to sense a blood stream.

Abstract: The invention relates to a sensor unit (100) for an implant system for medical support of a patient, wherein the sensor unit (100) comprises a carrier material (110) in which a recess (120) is formed and, furthermore, the sensor unit (100) comprises a semiconductor component (130) for forming a sensor, wherein the semiconductor component (130) is arranged in the recess (120) and, lastly, the sensor unit (100) comprises a substrate layer (140), which covers at least partially the recess (120) and/or comprises an opening (150) on at least one side of the sensor unit (110), as well as a diffusion barrier, by means of which at least the semiconductor component (130) is at least partially covered or coated in order to ensure a medium access (150) to the sensor.

Abstract: A method for operating smart glasses includes an input unit and/or output unit and a gaze detection arrangement, wherein the gaze detection arrangement detects any eye movement of an eye including the steps of irradiating at least one wavelength-modulated laser beam to the eye, detecting an optical path length of the emitted laser beam based on laser feedback interferometry of the emitted laser radiation with backscattered radiation from the eye, detecting a Doppler shift of the emitted and backscattered radiation based on the laser feedback interferometry, and detecting an eye velocity based on the Doppler shift, and wherein the input unit and/or output unit is operated based on the optical path length and/or the eye velocity.

Abstract: A method for detecting a gaze direction of an eye includes the steps of irradiating at least one wavelength-modulated laser beam onto an eye, detecting an optical path length of the emitted laser beam based on laser feedback interferometry of the emitted laser radiation with a backscattered radiation from the eye, detecting a Doppler shift of the emitted radiation and the backscattered radiation based on the laser feedback interferometry, detecting an eye velocity based on the Doppler shift, and detecting an eye movement of the eye based on the optical path length and the eye velocity.

Abstract: The invention relates to a method for determining a fluid volume flow (1) through an implanted vascular support system (2), comprising the following steps: a) determining a fluid temperature parameter in the region of a cannula (4) of the support system (2), b) operating a heating element (5) which can bring about a change in a fluid temperature in the cannula (4), c) determining the fluid volume flow (1) using at least the fluid temperature parameter or the change thereof and at least one heating element operating parameter or the change thereof. The invention also relates to a vascular support system.

Abstract: The invention relates to a method for detecting a state of wear of a cardiac support system. The method comprises a read-in step and a determination step. During the read-in step, a sensor signal (315) representing an operating state of the cardiac support system is read in. During the determination step, a wear signal (325) is determined using the sensor signal (315) and a comparison rule (320). The wear signal (325) represents the wear condition.

Abstract: The invention relates to a method for operating an implanted, ventricular assist system (2), comprising the following steps: a) determine a first impedance parameter at a first point in time by means of the assist system (2), b) determine a second impedance parameter at a second point in time by means of the assist system (2), c) at least determine a change of the impedance parameter using the first impedance parameter and the second impedance parameter, or compare at least the first or second impedance parameter to a threshold value.

Abstract: The invention relates to a method for determining a total fluid volume flow (1) in the region of an implanted vascular support system (2), comprising the following steps: a) determining a reference temperature (3) of the fluid, b) determining a motor temperature (4) of an electric motor (5) of the support system (2), c) determining the thermal dissipation loss (6) of the electric motor (5), d) ascertaining the total fluid volume flow (1) using the reference temperature (3), the motor temperature (4), and the thermal dissipation loss (6) of the electric motor (5).

Abstract: The invention relates to a method for determining a flow rate of a fluid flowing through an implanted vascular assist system (1), said method comprising the following steps: a) carrying out a first pulsed Doppler measurement at a first pulse repetition rate by means of an ultrasonic sensor (2) of the assist system (1); b) carrying out a second pulsed Doppler measurement at a second pulse repetition rate by means of the ultrasonic sensor (2) of the assist system (1), wherein the second pulse repetition rate differs from the first pulse repetition rate; c) determining the flow rate using measurement results of the first pulsed Doppler measurement and the second pulsed Doppler measurement.

Abstract: The invention relates to a line device (105) for a ventricular assist system (100), wherein the line device (105) comprises a guide cannula (145), which is structured at least partially along a direction of extent; and, furthermore, the line device (105) comprises an electrical conducting element (145), which is arranged in the guide cannula (140), wherein the electrical conducting element (145) comprises a multilayer structure.

Abstract: The invention relates to a method for determining the speed of sound in a fluid (1) in the region of an implanted, vascular support system (2), comprising the following steps: a) sending an ultrasonic signal (3) by means of an ultrasonic sensor (4) b) reflecting the ultrasonic signal (3) on at least one sound reflector (5), which is visible in the field of vision (6) of the ultrasonic sensor (4) and arranged at a defined distance at least to the ultrasonic sensor (4) or to a further sound reflector (5), c) receiving the reflected ultrasonic signal (8), d) determining the speed of sound in the fluid using the reflected ultrasonic signal (8).

Abstract: A chimeric antigen receptor is disclosed that includes: (a) an scFv comprising a light chain variable domain (VL) and a heavy chain variable domain (VH), wherein the scFv specifically binds to CCR4; (b) a hinge and transmembrane domain from CD8; (c) an intracellular 4-1BB signaling domain; and (d) an intracellular CD3 zeta signaling domain, wherein (a)-(d) are in N to C terminal order. Uses of the chimeric antigen receptor, such as for treating a malignancy, are also disclosed.

Abstract: The invention relates to a motor housing module (110) for sealing a motor compartment of a motor of a heart support system. The motor housing module (110) has at least one feed-through portion (205), at least one feed-through line (210), and at least one contact pin (215). The feed-through portion (205) is designed to establish an electrical connection between the heart support system and a connection cable in order to externally contact the heart support system. The at least one feed-through line (210) is embedded in the feed-through portion (205) and extends through the feed-through portion (205). The feed-through line (210) can be connected to the motor and to the connection cable. A first end of the at least one contact pin (215) is embedded in the feed-through portion (205) and a second end of the contact pin (215) projects from the feed-through portion (205) on a side facing away from the motor compartment.