Abstract: Described herein are compositions and methods for reducing off-target deposition of therapeutic and/or imaging agents in a subject with cancer comprising administering to the subject a predose of an interferon composition and/or a nucleic acid and a nanoparticle mimic, e.g., a lipoplex composition or a virus-like particle, such that epithelial tightening occurs in nontumor tissue of the subject thereby reducing uptake or accumulation of the therapeutic and/or imaging agent in off-target, nontumor tissue compared to tumor tissue.

Abstract: Drug delivery systems comprising binding partners conjugated to a nanoparticle encapsulating a therapeutic agent formulated for oral administration, and methods of delivering therapeutic agents across the gastrointestinal epithelium.

Abstract: Lipoplex formulations and uses thereof. In particular, the lipoplexes include at least one naturally-occurring cationic amphiphile, at least one C18-30 saturated fatty acid, cholesterol, at least one nucleic acid, and have a low charge ratio. The lipoplexes are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic therapeutic or an antisense therapeutic, such as an RNAi agent) and allow prolonged expression of these agents, which may be distributed via endogenous cellular pathways to surrounding cells or tissue.

Abstract: Topical compositions containing silibinin with enhanced silibinin penetration into the dermis. The compositions are useful for the treatment or prevention of skin damage or disorders.

Abstract: The methods of the invention employ electrostatic atomization to form a compound droplet of at least two miscible fluids. The compound droplet comprises a core of a first fluid and a layer of a second fluid completely surrounding the core. The first fluid contains the agent to be encapsulated and the second fluid contains an encapsulating agent. The first and second liquids are miscible. The encapsulated droplets can contain a variety of materials including, but not limited to, polynucleotides such as DNA and RNA, proteins, bioactive agents or drugs, food, pesticides, herbicides, fragrances, antifoulants, dyes, oils, inks, cosmetics, catalysts, detergents, curing agents, flavors, fuels, metals, paints, photographic agents, biocides, pigments, plasticizers, propellants and the like and components thereof. The droplets can be encapsulated by a variety of materials, including, but not limited to, lipid bilayers and polymer shells.