Abstract: Systems, methods, and computer-readable media for determining composition of chemical constituents in a complex mixture are disclosed. According to one aspect, a method for determining composition of chemical constituents in a complex mixture includes generating, using a separation tool and a mass spectrometer, separation and mass spectrometry data of a sample, wherein the separation data includes peak information and wherein the mass spectrometry data includes primary and secondary mass spectrometry data. The analysis results, including the generated separation and mass spectrometry data, are collected and stored. A chemical constituent of the sample is determined by comparing the analysis results to a library of information indicating characteristics of chemical entities, where the comparison is based on the separation and mass spectrometry information.

Abstract: The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.

Abstract: A system is provided for analyzing metabolomics data received from an analytical device across a group of samples. The system automatically receives a data matrix corresponding to each of the samples, wherein the data matrix includes rows corresponding to each of the samples and columns corresponding to a group of ions present in the respective samples. A processor is provided for determining a characteristic value corresponding to at least one of a group of components present in the samples, wherein the components are made up of at least a portion of the group of ions, using at least one of a correlation function and a factorization function. A user interface is in communication with the processor for displaying a visual indication of the characteristic value such that a user may receive a visual indication of the types of components present in the samples.

Abstract: The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.

Abstract: The present invention generates a visual display of metabolomic data compiled by a database and associated processor. More particularly, the present invention provides a database for automatically receiving a three-dimensional spectrometry data set for a group of samples. The present invention also provides a processor device for manipulating the data sets to produce plots that are directly comparable to a plurality of characteristic plots corresponding to a plurality of selected metabolites. Furthermore, the processor device may generate a visual display indicating the presence of the selected metabolites across the group of samples. Thus, the present invention enables a user to analyze a series of complex data sets in a visual display that may indicate the presence of the selected metabolites across the group of samples. Furthermore, the visual display generated by embodiments of the present invention also expedites the subjective analysis of the spectrometry data sets.

Abstract: A laterally adjustable conveyor utilizes a belt support assembly consisting of a plurality of pivoting support plates connected by pivots for sliding support of a flexible belt. A plurality of support stands provide support for the pivot plates from the floor or other supporting surface. A belt drive provides motive power for the flexible belt. A lateral adjustment assembly provides a means to position the back end laterally with respect to the front end of the conveyor by rotating pivot plates about plate pivots.

Abstract: An airfoil (30) having a continuous layer of ceramic matrix composite (CMC) material (34) extending from a suction side (33) to a pressure side (35) around a trailing edge portion (31). The CMC material includes an inner wrap (36) extending around an inner trailing edge portion (38) and an outer wrap (40) extending around an outer trailing edge portion (42). A filler material (44) is disposed between the inner and outer wraps to substantially eliminate voids in the trailing edge portion. The filler material may be pre-processed to an intermediate stage and used as a mandrel for forming the outer trailing edge portion, and then co-processed with the inner and outer wraps to a final form. The filler material may be pre-processed to include a desired mechanical feature such as a cooling passage (22) or a protrusion (48).

Abstract: A composite structure (62) having a bond enhancement member (76) extending across a bond joint (86) between a ceramic matrix composite (CMC) material (80) and a ceramic insulation material (82), and a method of fabricating such a structure. The bond enhancement member may extend completely through the CMC material to be partially embedded in a core material (84) bonded to the CMC material on an opposed side from the insulation material. A mold (26) formed of a fugitive material having particles (18) of a bond enhancement material may be used to form the CMC material. A two-piece mold (38, 46) may be used to drive a bond enhancement member partially into the CMC material. A compressible material (56) containing the bond enhancement member may be compressed between a hard tool (60) and the CMC material to drive a bond enhancement member partially into the CMC material.

Abstract: The present invention provides general affinity based methods for separating parental genetic material. Without limitation, the inventive methods may be used to separate maternal genetic material from paternal genetic material for haplotyping purposes. According to such embodiments, once the maternal genetic material has been separated from the paternal genetic material any method of SNP genotyping can be used, and the SNP genotypes will be, by definition the genetic haplotypes.

Abstract: A worm/worm gear assembly comprises a worm having teeth defined by at least one thread disposed thereon and a worm gear having teeth protruding from a surface thereof. At least one of the worm and the worm gear is fabricated from a resilient material. The teeth of the worm and the teeth of the worm gear are interengaged and in a compressive relationship with each other to maintain double flank contact therebetween. At low- or no-load conditions, the double flank contact is made at the opposing outer edges of each of the teeth. At moderate-load conditions, the contact extends from the opposing outer edges of each of the teeth toward the center of each of the teeth. A method for delashing a gear system comprises disposing the worm in mechanical communication with the worm gear and loading the worm gear to cause the worm gear to compressively engage the worm.

Abstract: Herein presented is a unique device for energy recovery. The centrifugal fan blades assembly of the device provides both the counter flow of air streams and the transfer of energy between the air streams. All the components of the device, the fan blades assembly, flow stream channels and air seals are housed together in a single economical unit.

Abstract: Disclosed are an oxide matrix composite that is stable for long-term exposures to temperatures of approximately 1,200° C. and the methods of making the ceramic matrix composite, including wet lay-up, prepreg, and filament winding fabrication methods. The oxide matrix composite can be made using commercially available refractory fibers that retain better than 85% of its original composite strength after 1,000 hours of exposure to such high temperature environments. The preferred alumina-based system demonstrates damage tolerance as relatively high strength retention properties and structural performance. The preferred refractory fibers are commercially available under the tradename of NEXTEL® 720.

Abstract: A worm/worm gear assembly comprises a worm having teeth defined by at least one thread disposed thereon and a worm gear having teeth protruding from a surface thereof. At least one of the worm and the worm gear is fabricated from a resilient material. The teeth of the worm and the teeth of the worm gear are interengaged and in a compressive relationship with each other to maintain double flank contact therebetween. At low- or no-load conditions, the double flank contact is made at the opposing outer edges of each of the teeth. At moderate-load conditions, the contact extends from the opposing outer edges of each of the teeth toward the center of each of the teeth. A method for delashing a gear system comprises disposing the worm in mechanical communication with the worm gear and loading the worm gear to cause the worm gear to compressively engage the worm.