Patents by Inventor Thomas Binz

Thomas Binz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-NEURONAL SNARE-CLEAVING BOTULINUM NEUROTOXINS
    Publication number: 20230312661
    Abstract: The present invention provides a modified botulinum neurotoxin A (BoNT/A) L-chain protease that demonstrates enhanced cleaveage of human SNAP-23 (hSNAP-23) relative to unmodified (wild-type) BoNT/A L-chain protease, together with the use thereof for cleaving hSNAP-23.
    Type: Application
    Filed: March 15, 2023
    Publication date: October 5, 2023
    Applicant: IPSEN BIOPHARM LIMITED
    Inventors: Thomas BINZ, Stefan SIKORRA
  • Non-neuronal snare-cleaving botulinum neurotoxins
    Patent number: 11634460
    Abstract: The present invention provides a modified botulinum neurotoxin A (BoNT/A) L-chain protease that demonstrates enhanced cleaveage of human SNAP-23 (hSNAP-23) relative to unmodified (wild-type) BoNT/A L-chain protease, together with the use thereof for cleaving hSNAP-23.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: April 25, 2023
    Assignee: IPSEN BIOPHARM LIMITED
    Inventors: Thomas Binz, Stefan Sikorra
  • NON-NEURONAL SNARE-CLEAVING BOTULINUM NEUROTOXINS
    Publication number: 20200239528
    Abstract: The present invention provides a modified botulinum neurotoxin A (BoNT/A) L-chain protease that demonstrates enhanced cleaveage of human SNAP-23 (hSNAP-23) relative to unmodified (wild-type) BoNT/A L-chain protease, together with the use thereof for cleaving hSNAP-23.
    Type: Application
    Filed: January 29, 2019
    Publication date: July 30, 2020
    Inventors: Thomas BINZ, Stefan SIKORRA
  • Botulinum neurotoxin a protein receptor and uses thereof
    Patent number: 8476024
    Abstract: The invention relates to an isolated polypeptide of the luminal domain of synaptic vesicle glycoprotein 2C of Homo sapiens wherein at least 70 percent of the amino acid sequence is identical to the amino acid sequence of the SV2C of Homo sapiens. The polypeptide binds the HC fragment of botulinum neurotoxin A provided that the polypeptide is not the synaptic vesicle glycoprotein 2C of Homo sapiens.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: July 2, 2013
    Assignee: Toxogen GmbH
    Inventors: Stefan Mahrhold, Johannes Wilhelm Bigalke, Andreas Rummel, Thomas Binz
  • Botulinum Neurotoxin a Protein Receptor and Uses Thereof
    Publication number: 20090252722
    Abstract: The invention relates to a polypeptide comprising an amino acid sequence, at least 70 percent of which are identical to the amino acid sequence of the synaptic vesicle glycoprotein of homo sapiens. Said polypeptide binds the HC fragment of botulinum neurotoxin A provided that the polypeptide is not the synaptic vesicle glycoprotein 2C of homo sapiens.
    Type: Application
    Filed: October 30, 2006
    Publication date: October 8, 2009
    Inventors: Stefan Mahrhold, Johannes Wilhelm Bigalke, Andreas Rummel, Thomas Binz