Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunctions; thus, there is also utility for small organic compound ligands and can raise LDL levels.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: This invention is related to the field of PCSK9 biology and the composition and methods of use of small organic compounds as ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small organic compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small organic compound ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small organic compound ligands that can raise LDL levels.

Abstract: A baffle for sound suppression, the baffle including a conical portion, a base portion, a lumen, and a cavity. The conical portion has a first end, a second end, and an outer surface extending from the first end to the second end and the base portion has a first surface and a second surface, the first surface and second surface being directed away from each other. The lumen has an inner surface and inner lip, the inner surface extending from the first end of the conical portion to the second surface of the base portion and the inner lip extending outwardly from and circumferentially around the inner surface and the cavity located between the first end and the second end of the conical portion and extending from the outer surface of the conical portion to the inner surface of the lumen.

Abstract: A baffle for sound suppression, the baffle including a conical portion, a base portion, a lumen, and a cavity. The conical portion has a first end, a second end, and an outer surface extending from the first end to the second end and the base portion has a first surface and a second surface, the first surface and second surface being directed away from each other. The lumen has an inner surface and inner lip, the inner surface extending from the first end of the conical portion to the second surface of the base portion and the inner lip extending outwardly from and circumferentially around the inner surface and the cavity located between the first end and the second end of the conical portion and extending from the outer surface of the conical portion to the inner surface of the lumen.

Abstract: Embodiments of the invention are generally directed to systems and methods for converting application code in a turbine control system. According to one embodiment of the invention, a method for converting a turbine control system may be provided for. The method may include providing a first application code format including one or more elements, providing a second application code format including one or more elements, and identifying mappings of the one or more first application code format elements to the one or more second application code format elements. The method may further include retrieving a first control system application code written in the first application code format, and generating application data from the first control system application code based at least in part on the identified mappings. Additionally, the method may include converting the application data to a second control system application code written in the second application code format.

Abstract: A diesel engine comprises a plurality of cylinders (2), an inlet duct (4), an exhaust duct (6), a turbocharger (8, 10) and a supercharger (14), the turbocharger being of variable output type and including a turbine (8) in the exhaust duct (6) and a supercharger (14) being of variable output type and situated in the inlet duct (4) between the compressor wheel (10) and the cylinders and being electrically driven or mechanically driven by the engine. The engine also includes a first sensor (25) arranged to produce a signal indicative of the speed of the engine, a second sensor (27) arranged to produce a signal indicative of the load to which the engine is subjected and a third sensor (26) arranged to produce a signal indicative of the pressure in the inlet duct (4) downstream of the supercharger (14). The sensors (25, 27, 26) are connected to a controller (29) which is also connected to the turbocharger and the supercharger and is arranged to vary their output independently.

Abstract: Embodiments of the invention are generally directed to systems and methods for converting application code in a turbine control system. According to one embodiment of the invention, a method for converting a turbine control system may be provided for. The method may include providing a first application code format including one or more elements, providing a second application code format including one or more elements, and identifying mappings of the one or more first application code format elements to the one or more second application code format elements. The method may further include retrieving a first control system application code written in the first application code format, and generating application data from the first control system application code based at least in part on the identified mappings. Additionally, the method may include converting the application data to a second control system application code written in the second application code format.

Abstract: A strap tightener is disclosed. The tightener includes a base member having edges for guiding a pair of threaded members. A drive member is mounted between the threaded members and a keeper is located adjacent the base for maintaining the base generally parallel to the length of strap during tightening.