Patents by Inventor Thomas Briese
Thomas Briese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230332254Abstract: Disclosed here are compositions and methods for the detection of at least one virus viruses using a one-step assay. The viruses to be detected include at least SARS-CoV-2 and influenza viruses. In particular, the disclosure relates to a method of detection of the viruses using specific primers and probes designed to detect and if necessary differentiate between the viruses.Type: ApplicationFiled: August 4, 2022Publication date: October 19, 2023Inventors: Walter Ian Lipkin, Thomas BRIESE, Nischay MISHRA, Rafal TOKARZ, Simon H. WILLIAMS
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Publication number: 20230184764Abstract: The current disclosure provides compositions, methods, and kits for detecting the exposure to and infection by certain viruses. Specifically, the current disclosure allows for the rapid differential serological detection of exposure to, and infection by viruses. In particular, the current disclosure allows for the rapid differential serological detection of exposure to, and infection by corona virus (SARS-CoV-2). The current disclosure provides for peptides for the differential detection of SARS-CoV-2.Type: ApplicationFiled: April 6, 2021Publication date: June 15, 2023Inventors: Walter Ian Lipkin, Nischay MISHRA, Thomas BRIESE, Cheng GUO, Shreyas JOSHI, Rafal TOKARZ
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Patent number: 11583579Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: GrantFiled: March 5, 2021Date of Patent: February 21, 2023Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, RAMOT AT TEL-AVIV UNIVERSITY LTD., KIMRON VETERINARY INSTITUTEInventors: W. Ian Lipkin, Thomas Briese, Nischay Mishra, Eran Bacharach, Avi Eldar
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Publication number: 20210205437Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: ApplicationFiled: March 5, 2021Publication date: July 8, 2021Inventors: W. Ian LIPKIN, Thomas BRIESE, Nischay Mishra, Eran Bacharach, Avi Eldar
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Patent number: 10973902Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: GrantFiled: February 6, 2020Date of Patent: April 13, 2021Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, RAMOT AT TEL-AVIV UNIVERSITY LTD., KIMRON VETERINARY INSTITUTEInventors: W. Ian Lipkin, Thomas Briese, Nischay Mishra, Eran Bacharach, Avi Eldar
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Publication number: 20210071172Abstract: The present invention provides novel methods, systems, tools, and kits for the simultaneous detection, identification and/or characterization of pathogenic bacteria known or suspected to infect vertebrates, more specifically humans, as well as the detection, identification and/or characterization of antimicrobial resistant genes and biomarkers and the detection of novel bacteria and/or antimicrobial resistant genes. The methods, systems, tools, and kits described herein are based upon the bacterial capture sequencing platform (BacCapSeq), a novel platform developed by the inventors. The invention also provides methods of designing and constructing the bacterial capture sequencing platform.Type: ApplicationFiled: November 9, 2020Publication date: March 11, 2021Inventors: Walter Ian Lipkin, Orchid Allicock, Cheng Guo, Thomas Briese, Nischay Mishra
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Patent number: 10829823Abstract: This invention relates to compositions and methods for the differential detection of multiple viruses using a one-step assay. The viruses to be detected include Zika, West Nile, dengue (genotype 1-4) and chikungunya viruses. In particular, the invention relates to a method of and assay for differential detection of the viruses using specific primers and probes designed to detect and differentiate between the viruses.Type: GrantFiled: March 17, 2017Date of Patent: November 10, 2020Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Walter Ian Lipkin, Nischay Mishra, Thomas Briese, Rafal Tokarz
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Patent number: 10815536Abstract: The present invention provides novel methods, systems, tools, and kits for the simultaneous detection, identification and/or characterization of all viruses known or suspected to infect vertebrates. The methods, systems, tools, and kits described herein are based upon the virome capture sequencing platform (“VirCapSeq-VERT”), a novel platform developed by the inventors. The invention also provides methods and kits for designing and constructing of the virome capture sequencing platform.Type: GrantFiled: September 19, 2016Date of Patent: October 27, 2020Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Walter Ian Lipkin, Omar Jabado, Thomas Briese, Amit Kapoor, Jan Gogarten, Komal Jain, Nischay Mishra
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Publication number: 20200255889Abstract: The current invention provides compositions, methods, and kits for detecting the exposure to and infection by certain agent or pathogens. Specifically, the current invention allows for the rapid differential serological detection of exposure to, and infection by tick-borne agents or pathogens using specific antigenic peptides.Type: ApplicationFiled: March 24, 2020Publication date: August 13, 2020Inventors: Rafal Tokarz, Walter Ian Lipkin, Nischay Mishra, Thomas Briese, Adrian Caciula
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Publication number: 20200254084Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: ApplicationFiled: February 6, 2020Publication date: August 13, 2020Inventors: W. Ian LIPKIN, Thomas BRIESE, Nischay Mishra, Eran Bacharach, Avi Eldar
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Patent number: 10596249Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: GrantFiled: August 23, 2018Date of Patent: March 24, 2020Assignees: KIMRON VETERINARY INSTITUTE, THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK, RAMOT AT TEL-AVIV UNIVERISTY LTD.Inventors: W. Ian Lipkin, Thomas Briese, Nischay Mishra, Eran Bacharach, Avi Eldar
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Publication number: 20190359694Abstract: The current invention provides compositions, methods, and kits for detecting the exposure to and infection by certain viruses. Specifically, the current invention allows for the rapid differential serological detection of exposure to, and infection by viruses. In particular, the current invention allows for the rapid serological detection of exposure to, and infection by Zika virus (ZIKV).Type: ApplicationFiled: December 1, 2017Publication date: November 28, 2019Inventors: Walter Ian Lipkin, Nischay Mishra, Thomas Briese, Adrian Caciula
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Publication number: 20190032152Abstract: This invention relates to compositions and methods for the differential detection of multiple viruses using a one-step assay. The viruses to be detected include Zika, West Nile, dengue (genotype 1-4) and chikungunya viruses. In particular, the invention relates to a method of and assay for differential detection of the viruses using specific primers and probes designed to detect and differentiate between the viruses.Type: ApplicationFiled: March 17, 2017Publication date: January 31, 2019Inventors: Walter Ian Lipkin, Nischay Mishra, Thomas Briese, Rafal Tokarz
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Patent number: 10183072Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: GrantFiled: December 15, 2015Date of Patent: January 22, 2019Assignees: KIMRON VETERINARY INSTITUTE, THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, RAMOT AT TEL-AVIV UNIVERSITY LTD.Inventors: W. Ian Lipkin, Thomas Briese, Nischay Mishra, Eran Bacharach, Avi Eldar
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Publication number: 20180369360Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: ApplicationFiled: August 23, 2018Publication date: December 27, 2018Inventors: W. Ian Lipkin, Thomas Briese, Nischay Mishra, Eran Bacharach, Avi Eldar
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Publication number: 20180265935Abstract: The present invention provides novel methods, systems, tools, and kits for the simultaneous detection, identification and/or characterization of all viruses known or suspected to infect vertebrates. The methods, systems, tools, and kits described herein are based upon the virome capture sequencing platform (“VirCapSeq-VERT”), a novel platform developed by the inventors. The invention also provides methods and kits for designing and constructing of the virome capture sequencing platform.Type: ApplicationFiled: September 19, 2016Publication date: September 20, 2018Applicant: The Trustees of Columbia University in the City of New YorkInventors: Walter Ian Lipkin, Omar Jabado, Thomas Briese, Amit KAPOOR
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Publication number: 20170360918Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.Type: ApplicationFiled: December 15, 2015Publication date: December 21, 2017Inventors: W. Ian LIPKIN, Thomas BRIESE, Nischay Mishra, Eran Bacharach, Avi Eldar
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Publication number: 20130071421Abstract: Isolated a Turkey Viral Hepatitis picomavirus-like viruses associated with Turkey viral hepatitis, and isolated nucleic acid sequences and polypeptides are disclosed. Antibodies against antigens from Turkey Viral Hepatitis picornavirus-like viruses, iRNAs which target nucleic acid sequences of the Turkey Viral Hepatitis picornavirus-like virus, methods for detecting the presence or absence of Turkey Viral Hepatitis picomavirus-like viruses in an animal, and immunogenic compositions for inducing an immune response against Turkey Viral Hepatitis picomavirus-like viruses in an animal are also disclosed.Type: ApplicationFiled: October 4, 2010Publication date: March 21, 2013Inventors: W. Ian Lipkin, Thomas Briese, Kirsi Honkavuori, H.L. Shivaprasad
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Patent number: 8216810Abstract: The present invention provides systems and methods for determining the presence or absence of one or more target nucleic acid sequences in a sample. Also provided are kits comprising these systems, and uses of these systems in such applications as determining the presence or absence of at least one target nucleic acid sequence in a sample, detecting microorganism transcripts and host transcripts, differentiating microorganism transcripts from host transcripts, screening blood products, assaying a food product for contamination, assaying a sample for environmental contamination, detecting genetically-modified organisms, biodefense, forensics, and genetic-comparability studies. The present invention further provides a complex that includes a target nucleic acid sequence, a capture nucleic acid, and a reporter nucleic acid.Type: GrantFiled: April 27, 2004Date of Patent: July 10, 2012Assignee: The Trustees of Columbia University in the City of New YorkInventors: W. Ian Lipkin, Thomas Briese, Gustavo Palacios, Omar Jabado
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Publication number: 20090275636Abstract: The invention is directed to a a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The invention also relates to antibodies against antigens derived from the picornavirus. The invention also relates to iRNAs which target nucleic acid sequences of the picornavirus. The invention is related to methods for detecting the presence or absence of picornavirus in a subject. The invention is also related to immunogenic compositions for inducing an immune response against picornavirus in a subject.Type: ApplicationFiled: February 2, 2009Publication date: November 5, 2009Applicant: The Trustees of Columbia University in the City of New YorkInventors: Thomas Briese, Gustavo Palacios, W. Ian Lipkin, Daryl Lamson