Patents by Inventor Thomas C. Moore
Thomas C. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120010105Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.Type: ApplicationFiled: September 20, 2011Publication date: January 12, 2012Inventors: Stephen J. Caracci, Volker H.O. Eckelt, Anthony G. Frutos, Mark F. Krol, Thomas C. Moore, David A. Pastel, Gordon M. Shedd
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Patent number: 8062226Abstract: A catheter has a proximal end and a distal end and comprises an outer tube having a proximal end, an inner sheath slidingly received within the outer tube and extending distally from the outer tube, and a rotatable shaft extending from the proximal end of the outer tube to within the inner sheath. The rotatable shaft is axially fixed with respect to the outer tube and axially moveable within and with respect to the inner sheath. The rotatable shaft includes a proximal substantially rigid section and a distal flexible section. The catheter further includes a working element carried on the distal flexible section of the rotatable shaft.Type: GrantFiled: December 16, 2008Date of Patent: November 22, 2011Assignee: Silicon Valley Medical Instruments, Inc.Inventor: Thomas C. Moore
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Patent number: 7976217Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.Type: GrantFiled: September 15, 2006Date of Patent: July 12, 2011Assignee: Corning IncorporatedInventors: Mark F. Krol, Thomas C. Moore, David A. Pastel, Gordon M. Shedd
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Publication number: 20110142092Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.Type: ApplicationFiled: February 24, 2011Publication date: June 16, 2011Inventors: Mark F. Krol, Thomas C. Moore, David A. Pastel, Gordon M. Shedd
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Publication number: 20110087104Abstract: An intravascular ultrasound imaging system comprises a catheter having an elongated body having a distal end and an imaging core arranged to be inserted into the elongated body. The imaging core is arranged to transmit ultrasonic energy pulses and to receive reflected ultrasonic energy pulses. The system further includes an imaging engine coupled to the imaging core and arranged to provide the imaging core with energy pulses to cause the imaging core to transmit the ultrasonic energy pulses. The energy pulses are arranged in repeated sequences and the energy pulses of each sequence have varying characteristics. The reflected pulses may be processed to provide a composite image of images resulting from each different characteristic.Type: ApplicationFiled: October 12, 2010Publication date: April 14, 2011Applicant: Silicon Valley Medical Instruments, Inc.Inventors: Thomas C. MOORE, Kendall R. Waters, J. Steve Reynolds, Duc H. Lam, Donald Masters
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Publication number: 20110021911Abstract: An endoventricular injection catheter with integrated echocardiographic capability enables injections into heart tissue under visualization. The catheter includes an elongated body having a distal end and an imaging core arranged to be inserted into a heart. The imaging core is arranged to transmit ultrasonic energy and to receive reflected ultrasonic energy at the distal end to provide electrical signals representing echocardiographic images to enable cardiac visualization. The catheter further includes an injector carried on the elongated body with the imaging core. The injector is arranged to inject a therapeutic agent into tissue of the heart visualized by the imaging core.Type: ApplicationFiled: July 16, 2010Publication date: January 27, 2011Applicant: Silicon Valley Medical Instruments, Inc.Inventors: Kendall R. Waters, Thomas C. Moore, Robert Zelenka, Paul Zalesky
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Publication number: 20100225921Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.Type: ApplicationFiled: September 15, 2006Publication date: September 9, 2010Inventors: Mark F. Krol, Thomas C. Moore, David A. Pastel, Gordon M. Shedd
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Publication number: 20100152590Abstract: A catheter-based imaging system comprises a catheter having a telescoping proximal end, a distal end having a distal sheath and a distal lumen, a working lumen, and an ultrasonic imaging core. The ultrasonic imaging core is arranged for rotation and linear translation. The system further includes a patient interface module including a catheter interface, a rotational motion control system that imparts controlled rotation to the ultrasonic imaging core, a linear translation control system that imparts controlled linear translation to the ultrasonic imaging core, and an ultrasonic energy generator and receiver coupled to the ultrasonic imaging core. The system further comprises an image generator coupled to the ultrasonic energy receiver that generates an image.Type: ApplicationFiled: December 8, 2009Publication date: June 17, 2010Applicant: Silicon Valley Medical Instruments, Inc.Inventors: Thomas C. Moore, Kendall R. Waters, Stephanie J. Buech, Robert Zelenka
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Patent number: 7686816Abstract: The system (2) includes a catheter drive unit (22) and a catheter (24) extending therefrom movably mounted to a catheter drive sled (26). The catheter drive unit rotates and translates the catheter core (34) within the catheter sheath (36). The sled has a serrated, conical drive unit interface (82), with a bag-piercing tip (86) mateable with a translator drive output (92) so that a sterile drape (112) enclosing the catheter drive unit is automatically pierced when the catheter drive unit is mounted to the sled. A control unit (6) is spaced apart from the catheter drive unit and provides power and commands to the catheter drive unit and receives information and data from the catheter drive unit. The rotator and translator drive motors (54, 90) are operated from both the control unit and the catheter drive unit. Both the control unit and catheter drive unit have translation displacement displays (10, 30).Type: GrantFiled: October 18, 2005Date of Patent: March 30, 2010Assignee: Boston Scientific Scimed, Inc.Inventors: W. Martin Belef, John H. Ream, Thomas C. Moore, Steven N. Roe, Jeffrey M. Jones, Niyazi Beyhan, Arcadi Elbert
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Publication number: 20090284332Abstract: An imaging system comprises a catheter having a lumen, a rotatable imaging probe within the catheter lumen including a distal transducer and first and second conductors coupled to the transducer, and a coupler that couples the rotatable first and second conductors to non-rotatable third and fourth conductors, respectively. The coupler includes a rotary capacitive coupler.Type: ApplicationFiled: May 14, 2009Publication date: November 19, 2009Applicant: Silicon Valley Medical Instruments, Inc.Inventors: Thomas C. Moore, Robert Zelenka
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Publication number: 20090247427Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.Type: ApplicationFiled: June 9, 2009Publication date: October 1, 2009Inventors: Stephen J. Caracci, Volker H.O. Eckelt, Anthony G. Frutos, Mark F. Krol, Thomas C. Moore, David A. Pastel, Gordon M. Shedd
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Publication number: 20090177093Abstract: An imaging probe for use in a catheter for ultrasonic imaging is provided. The catheter may be of the type including a sheath having an opening at a distal end for conducting a fluid there through. The imaging probe includes a distal housing coupled to a drive shaft for rotation, a transducer within the distal housing for generating and sensing ultrasonic waves, and a fluid flow promoter that promotes flow of the fluid within the sheath across the transducer.Type: ApplicationFiled: December 8, 2008Publication date: July 9, 2009Applicant: Silicon Valley Medical Instruments, Inc.Inventors: Robert Zelenka, Thomas C. Moore
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Publication number: 20090156941Abstract: A catheter has a proximal end and a distal end and comprises an outer tube having a proximal end, an inner sheath slidingly received within the outer tube and extending distally from the outer tube, and a rotatable shaft extending from the proximal end of the outer tube to within the inner sheath. The rotatable shaft is axially fixed with respect to the outer tube and axially moveable within and with respect to the inner sheath. The rotatable shaft includes a proximal substantially rigid section and a distal flexible section. The catheter further includes a working element carried on the distal flexible section of the rotatable shaft.Type: ApplicationFiled: December 16, 2008Publication date: June 18, 2009Applicant: Silicon Valley Medical Instruments, Inc.Inventor: Thomas C. Moore
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Publication number: 20090105779Abstract: Lead Tracking of Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Devices improve upon the process of implantation of ICD-CRT devices, placing their leads, and improving the information fed back to the device and/or clinician. Tracking of the placement of the leads during implantation is accomplished along with monitoring the leads once implanted. Benefits include reducing the risk and complication rate, simplifying implantation procedure, and enabling the extraction of vital data not previously available. Leads are tracked to at least minimize the need to use fluoroscopy. Three dimensional tracking (10) is employed to facilitate obtaining of data that allows the surgeon to better visualize lead insertion and placement. Placement of the leads during a procedure requires use of an external tracking component along with means and method for tracking the implantable leads.Type: ApplicationFiled: March 6, 2007Publication date: April 23, 2009Applicant: ASCENSION TECHNOLOGY CORPORATIONInventors: Thomas C. Moore, Mark Schneider
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Patent number: 7314448Abstract: An improved medical imaging device assembly includes an imaging transducer coupled to the distal end of a drive shaft, and a conductive wire is wrapped around a distal portion of the drive shaft, wherein the conductive wire reinforces the imaging device assembly. In one embodiment, the conductive wire is part of a sensor adapted to communicate with a medical positioning system. In another embodiment, the conductive wire is configured to be a matching circuit for the imaging transducer. The conductive wire may be configured to be in parallel with the imaging transducer or configured to be in series with the imaging transducer.Type: GrantFiled: January 9, 2004Date of Patent: January 1, 2008Assignee: SciMed Life Systems, Inc.Inventors: Louis J. Barbato, Isaac Ostrovsky, Paul Goll, Thomas C. Moore, Douglas M. Petty, Mark Hamm, Richard Romley
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Patent number: 7278324Abstract: A sensor has a plurality of carbon nanotube (CNT)-based conductors operatively positioned on a substrate. The conductors are arranged side-by-side, such as in a substantially parallel relationship to one another. At least one pair of spaced-apart electrodes is coupled to opposing ends of the conductors. A portion of each of the conductors spanning between each pair of electrodes comprises a plurality of carbon nanotubes arranged end-to-end and substantially aligned along an axis. Because a direct correlation exists between the resistance of a carbon nanotube and its strain, changes experienced by the portion of the structure to which the sensor is coupled induce a corresponding change in the electrical properties of the conductors, thereby enabling detection of crack growth in the structure.Type: GrantFiled: June 15, 2005Date of Patent: October 9, 2007Assignee: United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Jan M. Smits, Marlen T. Kite, Thomas C. Moore, Russell A. Wincheski, JoAnne L. Ingram, Anthony N. Watkins, Phillip A. Williams
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Patent number: 6974465Abstract: The system (2) includes a catheter drive unit (22) and a catheter (24) extending therefrom movably mounted to a catheter drive sled (26). The catheter drive unit rotates and translates the catheter core (34) within the catheter sheath (36). The sled has a serrated, conical drive unit interface (82), with a bag-piercing tip (86) mateable with a translator drive ouput (92) so that a sterile drape (112) enclosing the catheter drive unit is automatically pierced when the catheter drive unit is mounted to the sled. A control unit (6) is spaced apart from the catheter drive unit and provides power and commands to the catheter drive unit and receives information and data from the catheter drive unit. The rotator and translator drive motors (54, 90) are operated from both the control unit and the catheter drive unit. Both the control unit and catheter drive unit have translation displacement displays (10, 30).Type: GrantFiled: May 6, 2002Date of Patent: December 13, 2005Assignee: Boston Scientific SciMed, Inc.Inventors: W. Martin Belef, John H. Ream, Thomas C. Moore, Steven N. Roe, Jeffrey M. Jones, Niyazi Beyhan, Arcadi Elbert
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Patent number: 6862467Abstract: A catheter assembly includes an elongate catheter body having a proximal end and a distal end with a drive cable disposed therein, the drive cable having a proximal end and a distal end, and rotatable relative to the catheter body. A first electro-magnetic element is disposed proximate the distal end of the catheter, and a second electro-magnetic element disposed proximate the distal end of the drive cable and in electrical communication with an operative element mounted at the end of the drive cable, the first and second electro-magnetic elements forming an inductive coupler. The catheter assembly can include various other distal operative elements, which are in communication with corresponding proximal operative elements via transmission lines embedded within the wall of the catheter body.Type: GrantFiled: August 9, 2002Date of Patent: March 1, 2005Assignee: SciMed Life Systems, Inc.Inventors: Thomas C. Moore, Eric Williams, David A. White, Donald S. Mamayek, Donald Masters, Martin Belef, Veijo Soursa
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Publication number: 20040193057Abstract: An improved medical imaging device assembly includes an imaging transducer coupled to the distal end of a drive shaft, and a conductive wire is wrapped around a distal portion of the drive shaft, wherein the conductive wire reinforces the imaging device assembly. In one embodiment, the conductive wire is part of a sensor adapted to communicate with a medical positioning system. In another embodiment, the conductive wire is configured to be a matching circuit for the imaging transducer. The conductive wire may be configured to be in parallel with the imaging transducer or configured to be in series with the imaging transducer.Type: ApplicationFiled: January 9, 2004Publication date: September 30, 2004Applicant: SCIMED LIFE SYSTEMS, INC.Inventors: Louis J. Barbato, Isaac Ostrovsky, Paul Goll, Thomas C. Moore, Douglas M. Petty, Mark A. Hamm, Richard Romley
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Patent number: 6511432Abstract: An ultrasound catheter is disclosed wherein a rotatable transducer couples to the input of a preamplifier. Protection circuits at the input and output of the preamplifier protect the preamplifier from the transducer excitation signal. The preamplifier couples to the distal end of a transmission line. In an alternate embodiment, at least one switch responds to the presence of the transducer excitation signal by coupling the transducer excitation signal to the rotatable transducer and protecting the preamplifier from the transducer excitation signal. The at least one switch responds to the absence of the transducer excitation signal by coupling a received signal produced by the rotatable transducer to the input of the preamplifier. The at least one switch further responds to the absence of the transducer excitation signal by coupling the output of the preamplifier to the distal end of the transmission line.Type: GrantFiled: April 27, 2001Date of Patent: January 28, 2003Assignee: Scimed Life Systems, Inc.Inventors: Thomas C. Moore, Veijo Suorsa, Donald Masters