Abstract: Disclosed herein is a method for preparing an aloe extract. The method comprises steps of, mincing a mesophyll of an Aloe in water; heating the minced mixture to 60-80° C.; filtering the mixture to produce a first filtrate; drying the first filtrate; reconstituting the dried first filtrate in water; subjecting the first filtrate or the reconstituent to column chromatography and eluting the column with a first polar solvent; concentrating the eluent; purifying the concentrate with active carbons; filtering the purified concentrate to produce a second filtrate; concentrating the second filtrate; and adding a second polar solvent to the concentrated second filtrate thereby producing the aloe extract. The present disclosure also encompasses the aloe extract prepared by the present method. Said aloe extract has desired contents of O-acetyl groups or polysaccharides, and is useful for manufacturing food, pharmaceutical, or cosmetic products.

Abstract: A surgical kit includes a shield for covering a portion of the spine of a subject. The shield can include an attachment portion adapted to engage a bone fixation assembly which is adapted to be fixed on multiple vertebra bones of the subject. The bone fixation assembly can include a vertebra joining member secured between two bone anchors. Each bone anchor can include a fastener portion adapted to be implanted into a vertebra bone and a head coupling portion adapted to secure the vertebra joining member. The shield can be coupled to the bone fixation assembly via separate coupling elements, such as a clip or an adjustable link secured between two vertebra joining members of the bone fixation assembly. Alternatively, the shield can include an integral attachment portion configured to engage the bone fixation assembly directly.

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract: Electrochemical sensing devices and methods of using thereof employs a set of one or more sensor-integrated sampling wells or containers that operates with a pressure differential micro-valve to move controlled volume of sampled fluid within a controlled cell-growing environment. The differential micro-valve can be integrated into an instrumented well having one or more sensors to provide a high-throughput smart well plate platform for use in automation operation in diagnostics and drug discovery.

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

Abstract: The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract: An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.

Abstract: Methods and systems are presented for providing instant authentication of a product and enhanced user experience with the product via blockchain technologies. A product verification system uses blockchain technologies to track the supply chain process of each instance (e.g., each copy) of a product. Upon receiving a request for authenticating an item, a code provided with the item is scanned. A token corresponding to an instance of a product is determined based on the code. The product verification system traverses a blockchain to access data associated with the token. The item is authenticated based on the data. Additional content provided by the supply chain and/or the manufacturer of the instance of the product may be presented on a user device in response to authenticating the item.

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as a primary cutaneous lymphoma which may be a cutaneous T cell lymphoma (CTCL). The CTCL may be mycosis fungoides, primary cutaneous anaplastic large cell lymphoma (ALCL), or Sezary syndrome. A patient may be administered a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene).

Abstract: Methods and systems are presented for analyzing feedback data associated with a content and generating an interactive graphical representation of the feedback data. Upon receiving a request from a user, a feedback analysis system may access feedback data associated with a content from a content hosting server. The feedback data may include comments submitted by viewers of the content. The feedback analysis system may analyze the comments and generate an interactive graphical representation of the feedback data. The interactive graphical representation may include icons that represents keywords that are relevant to the comments and sentiments of the viewers derived based on the comments. Upon receiving a selection of an icon, the feedback analysis system may present a comment that corresponds to the keyword and/or sentiment represented by the icon.

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

Abstract: A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

Abstract: A multiplexed inductive tactile sensor for measuring location and force of contact with an external object includes sense and drive electronics and an array of sensels, each having a drive coil inductively coupled with a sense coil. The array has rows and columns of sensels. Drive coils in each column are electrically connected in series and driven by an AC constant current source through an analog demultiplexer. All sense coils in each row are electrically connected in series and the induced AC voltage across the row is fed to an AC amplifier through an analog multiplexer. The amplified AC voltage is then fed to the amplitude demodulator to generate a DC signal that is dependent on the inductive coupling factor between drive coil and sense coil of a sensel that is selected by being the intersection of the active current drive column and sense row. A first deformable conductive shield layer may be disposed adjacent to a first compressible dielectric layer disposed on first side of a PCB.

Abstract: Methods and systems are presented for providing instant authentication of a product and enhanced user experience with the product via blockchain technologies. A product verification system uses blockchain technologies to track the supply chain process of each instance (e.g., each copy) of a product. Upon receiving a request for authenticating an item, a code provided with the item is scanned. A token corresponding to an instance of a product is determined based on the code. The product verification system traverses a blockchain to access data associated with the token. The item is authenticated based on the data. Additional content provided by the supply chain and/or the manufacturer of the instance of the product may be presented on a user device in response to authenticating the item.

Abstract: According to one embodiment, an RF frontend IC device includes a first RF transceiver to transmit and receive RF signals within a first frequency band and a second RF transceiver to transmit and receive RF signals within a second frequency band that is different than the first frequency band. The RF frontend IC device further includes a converter and a multi-band local oscillator (LO) generator to provide LO signals to the converter. The multi-band LO generator includes a phase-lock loop (PLL) circuit operating at a PLL operating frequency, wherein the PLL operating frequency is outside of the first frequency band and the second frequency band. The multi-band LO generator also includes multiple frequency multipliers coupled to the PLL circuit to upscale the PLL operating frequency and to generate an LO signal having a frequency within a predetermined proximity from the frequency band.

Abstract: The invention relates to Cu-embedded masterbatches forming by a novel formulation and its production process. The novel formulation comprises a mixing powder prepared from Cu2O and ZnO. The mixing powder is milled in water to form slurry. Spray-dry the slurry at 130˜150° C. to get anti-bacterial powder. Add 12 wt. %˜15 wt. % of the anti-bacterial powder to plastic masterbatches and follow by pre-mixing, heating, stirring, melting, extruding, cooling and cutting process to obtain the Cu-embedded masterbatches.

Abstract: Methods and systems are presented for providing instant authentication of a product and enhanced user experience with the product via blockchain technologies. A product verification system uses blockchain technologies to track the supply chain process of each instance (e.g., each copy) of a product. Upon receiving a request for authenticating an item, a code provided with the item is scanned. A token corresponding to an instance of a product is determined based on the code. The product verification system traverses a blockchain to access data associated with the token. The item is authenticated based on the data. Additional content provided by the supply chain and/or the manufacturer of the instance of the product may be presented on a user device in response to authenticating the item.

Abstract: According to one embodiment, a transformer-based in-phase and quadrature (IQ) includes a differential balun having a first inductor and a second inductor. The first inductor has a first input terminal and a first output terminal. The second inductor has a second input terminal and a second output terminal. Additionally, the IQ generator circuit includes a third inductor magnetically coupled with the first inductor. The third inductor has a first isolation terminal and a third output terminal. The IQ generator circuit also includes a fourth inductor magnetically coupled with the second inductor. The fourth inductor has a second isolation terminal and a fourth output terminal. The IQ generator circuit additionally includes a first transistor coupled to the first input terminal of the first inductor. Further, the generator circuit includes a second transistor coupled to the second input terminal of the second inductor.

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Abstract: Techniques for managing a parts catalog of part objects corresponding to media content items are provided. Upon receiving a request to build a new part object for a part provider management system for a new content item, one embodiment collects a plurality of contribution references corresponding to a plurality of contributions relating to the new content item. A new part object is built based on the plurality of contributions and using a part creation graph corresponding to a type of the new content item. The new part object is published to a parts catalog for the part provider management system, for consumption by one or more downstream systems.