Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing oxidative stress, for example in patients with type 1 or type 2 diabetes, as well as to the use of such SGLT-2 inhibitors in treatment and/or prevention of cardiovascular diseases in patients, for example type 1 or type 2 diabetes patients. The present invention further relates to certain SGLT-2 inhibitors for treating and/or preventing a metabolic disorder and preventing, reducing the risk of or delaying the occurrence of a cardiovascular event in patients, for example patients with type 1 or type 2 diabetes.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: Provided are methods of preparing an electrochemically active cathode material including the steps of combining an alkali metal-containing nickel oxide having a formula A1?aNi1+aO2, wherein A comprises an alkali metal and 0<a?0.2, with a fluid composition including an oxidant comprising a peroxydisulfate salt, a monopersulfate salt, or a combination thereof to form a mixture, heating the mixture to a temperature of 50° C. or greater; and maintaining the mixture at the temperature for at least a period of time sufficient to form an alkali metal-deficient nickel oxide electrochemically active cathode material having a general formula AxHyNi1+aO2·nH2O, wherein A comprises an alkali metal; 0.08?x<0.2; 0?y<0.3; 0.02?a?0.2; and 0<n<2.

Abstract: The invention relates to a large-scale hydrogen refueling station comprising at least one supply storage, a plurality of compressor modules comprising a local controller, a plurality of dispenser modules, and a hydrogen production system comprising a hydrogen production system controller mutually connected by one or more flow paths. Wherein one of the controllers facilitates control of valves and thereby flow of hydrogen gas in the flow paths between the at least one supply storage, compressor modules, dispenser modules and hydrogen production system. Wherein the control of the valves enables flow of hydrogen gas in at least three of the flow paths simultaneously.

Abstract: The present invention relates i.a. to a recombinant avian coronavirus spike protein or fragment thereof comprising a mutation at amino acid position 267 to Cysteine. Further, the present invention relates to an immunogenic composition comprising an avian coronavirus with such spike protein.

Abstract: The invention relates to a protective helmet with an outer shell (1) for distributing impact forces, an interior layer (2) accommodated by the outer shell (1) for attenuating impact forces, and a slot (3) for accommodating an electrical device (4), wherein the outer shell (1) has a chin shell area (6) to cover a chin portion of a protective helmet wearer, wherein the outer shell (1) forms a viewing port (8) for the protective helmet wearer to look through. The protective helmet is characterized in that the slot (3) is arranged on the chin shell area (6) in such a way that the accommodated electrical device (4) is arranged between the chin shell area (6) and the interior layer (2), wherein the protective helmet has an interior cover (10) for essentially completely covering the accommodated electrical device (4) in the direction of the viewing port (8).

Abstract: This invention relates to tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.

Abstract: The present invention relates to certain SGLT-2 inhibitors for treating and/or preventing oxidative stress, for example in patients with type 1 or type 2 diabetes, as well as to the use of such SGLT-2 inhibitors in treatment and/or prevention of cardiovascular diseases in patients, for example type 1 or type 2 diabetes patients. The present invention further relates to certain SGLT-2 inhibitors for treating and/or preventing a metabolic disorder and preventing, reducing the risk of or delaying the occurrence of a cardiovascular event in patients, for example patients with type 1 or type 2 diabetes.

Abstract: Approaches, techniques, and mechanisms are disclosed for predicting molecular electronic structural information. According to one embodiment, quantum simulation results are generated for a molecule based on a quantum simulation of an electronic structure of the molecule. The quantum simulation of the electronic structure of the molecule is performed with quantum processing units. An input vector comprising data field values derived from the quantum simulation results for the molecule is created. An electronic structural information prediction model is applied to generate, based at least in part on the input vector, predicted electronic structural information for the molecule.

Abstract: The invention relates to a large-scale hydrogen refueling station comprising at least one supply storage, a plurality of compressor modules comprising a local controller, a plurality of dispenser modules, and a hydrogen production system comprising a hydrogen production system controller mutually connected by one or more flow paths. Wherein one of the controllers facilitates control of valves and thereby flow of hydrogen gas in the flow paths between the at least one supply storage, compressor modules, dispenser modules and hydrogen production system. Wherein the control of the valves enables flow of hydrogen gas in at least three of the flow paths simultaneously.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: A method for performing computing procedures with a control unit of a transportation vehicle wherein the control unit is not installed in a fixed position in the transportation vehicle, but is instead a removable design. The control unit performs control tasks for transportation vehicle functions in the transportation vehicle and is used outside the transportation vehicle for vehicle-independent calculations. The control unit in the transportation vehicle uses a computing power and/or memory capacity which is/are not required for the control tasks for vehicle-independent calculations in the transportation vehicle, wherein these vehicle-independent calculations are continued outside the transportation vehicle when the control unit is removed from the transportation vehicle.

Abstract: A brush burning tool includes a tubular metal shaft terminating in a hollow metal head portion, with a plurality of apertures arrayed around the head. A blower attached to the open end of the tubular metal shaft delivers air through the shaft and out through the apertures in the head portion to facilitate burning of a pile of biomass.

Abstract: A multi-voltage domain device includes a semiconductor layer including a first main surface, a second main surface arranged opposite to the first main surface, a first region including first circuitry that operates in a first voltage domain, a second region including second circuitry that operates in a second voltage domain different than the first voltage domain, and an isolation region that electrically isolates the first region from the second region in a lateral direction that extends parallel to the first and the second main surfaces. The isolation region includes at least one deep trench isolation barrier, each of which extends vertically from the first main surface to the second main surface. The multi-voltage domain device further includes at least one first capacitor configured to generate an electric field laterally across the isolation region between the first region and the second region.

Abstract: A configurable universal wellbore reactor system designed for localized heat, pressure, and reaction control, to facilitate desired reactor conditions to transform feedstocks to recoverable products via diluent- based processes and/or reactions. The present system provides for a universal wellbore reactor for the diluent transformation of a diverse range of feedstocks, such as hydrocarbon waste, municipal waste, industrial waste, and/or mineral rich resources to recoverable product(s). Heat and temperature within the wellbore reactor are controlled by configuring various reactor components to govern the direction and magnitude of internal and external heat transfer within. Together with skin frequency heat transfer of ferromagnetic reactor piping at predetermined locations, the required temperature(s) and pressure(s) for the desired targeted reactions and/ or transformation reactions are achieved.

Abstract: A multi-voltage domain device includes a semiconductor layer including a first main surface, a second main surface arranged opposite to the first main surface, a first region including first circuity that operates in a first voltage domain, a second region including second circuity that operates in a second voltage domain different than the first voltage domain, and an isolation region that electrically isolates the first region from the second region in a lateral direction that extends parallel to the first and the second main surfaces. The isolation region includes at least one deep trench isolation barrier, each of which extends vertically from the first main surface to the second main surface. The multi-voltage domain device further includes at least one first capacitor configured to generate an electric field laterally across the isolation region between the first region and the second region.

Abstract: A thermal monitoring system (101) for sensing a temperature of a monitored device (104) includes a carrier (102) having a first surface (112) and a biasing element (122) coupled to the carrier (102) and configured to extend between the carrier (102) and the monitored device (104) to provide a first thermal conduction path therebetween. The biasing element (122) includes a first end (128) contacting the first surface (112) and a second end (130) opposite the first end (128) and configured to contact the monitored device (104). The biasing element (122) further includes a main body (132) formed of a thermally conductive material extending continuously between the first end (128) and the second end (130). The main body (132) is compressible between the monitored device (104) and the carrier (102). The thermal monitoring system (101) further includes a temperature sensor (124) coupled to the carrier (102) and configured to detect a temperature of the monitored device (104).