Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ?-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ?-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ?-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ?-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ?-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ?-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ?-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ?-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

Abstract: The present invention relates to a synthetic prosthesis for tissue reinforcement comprising: a porous knit made from a monofilament of a synthetic biocompatible material, said knit defining two opposite faces, a first face and a second face, a synthetic non porous biodegradable film comprising at least a copolymer of at least ?-caprolactone, said film covering at least part of said first face, a synthetic biodegradable binder bonding said film to said first face, said binder comprising at least a polymer of ?-caprolactone, wherein said second face of said porous knit is left open to cell colonization. The invention also relates to a method for forming such a prosthesis.

Abstract: The method for making microfluidic connections includes the steps of providing a system including a base, a movable device in communication with the base, and a sealing component attached to the movable device; delivering a microfluidic device to the base; aligning the sealing component and the microfluidic device, wherein the moveable device is capable of adjustably positioning the sealing component and capable of optical alignment, to bring the sealing component and the microfluidic device into fluid communication; and compressing the sealing component and the microfluidic device into contact thereby forming a microfluidic connection by creating a leak-resistant seal between at the interface of the sealing component and the microfluidic device.

Abstract: The invention allows for the formation of robust, reproducible, non-permanent connections to microchips. The connections are formed using either indexing arms or multiple fitting holder heads which are capable of forming a compression seal to a port located at any position on the surface of the microchip. The sealing force is user-defined and can be tightly controlled with integrated force sensors. In addition, the sealing force is monitored with a force sensor and force compensation mechanism ensuring that the desired force is maintained. The device is compatible with all microchip architectures. Alterations to the microchip surface is avoided as connections are established using instrumentation rather than processing steps. Further, the process is automatable allowing for exchanging microchips and subsequently creating electrical and fluidic connections in an automated fashion. Optionally, the integration of leak sensors to monitor leaks are included.

Abstract: Atmospheric pressure ionization (API) interface structures such as API interface structures for mass spectrometers and related components, systems and methods are described herein.

Abstract: A method of preventing analyte electrolysis in use with electrospray ionization, electrophoresis, electro osmosis, electrodialysis and any apparatuses involving contact of liquids and electrodes is disclosed. The method for preventing analyte alteration by electrolysis reactions at electrode surfaces of an electrochemical system and in an electrochemical process includes coating the electrode surface using electrically insulating material including but not limited to polymers, plastics, and organic compounds by coating methods including but not limited to liquid spraying, spinning, molding, Sol Gel, dipping, physical vapor deposition and chemical vapor deposition at various ambient and substrate temperatures.

Abstract: An ultra-low volume fraction collection and concentration method provides practical application in collecting fractions, e.g. as low as 25 nL, from nanoLC columns into pipette tips at user-defined timed-intervals. The fractions are dried to create a concentrated band at the very end of the interior of the pipette tip and subsequently reconstituted directly in the pipette tips in solvent prior to analysis. As the chromatography and reconstitution solvent choice are independent, the reconstitution solvent can be selected to maximize ionization efficiency without compromising chromatography separation. In the infusion analysis of the nanoLC fractions, a low flow electrospray chip enables each nanoLC fraction to be analyzed for over ten minutes. This increase in analysis time allows for advantages over prior methods. Optionally, the nanoLC fractions can be archived in the pipette tips for analysis at a later date.

Abstract: A system and method for monitoring, controlling and recording the interactions of a substance interaction device with substances and/or other devices is disclosed. The system includes a substance interaction device, a robotic substance delivery system, and a computer. The substance interaction device stores data describing the device and interactions of the device with substances and/or other devices or systems. The computer obtains the data from the substance interaction device and monitors and controls interactions between the substance interaction device with substances or other devices, such as the robotic substance delivery system.

Abstract: A robotic autosampler provides for automated manipulation of microfluidic chips having multiple electrospray devices and/or sample inlets for interface to a mass spectrometer or other detection device. The autosampler also provides for connection of control voltages to the electrospray device to facilitate enablement, control and steering of charged droplets and ions. The autosampler further provides a method of fluid delivery that may be disposable or reusable. The delivery device may contain materials for component separation or sample purification. The delivery device may contain preloaded sample or the sample may be loaded by the autosampler.

Abstract: A droplet/electrospray device and a liquid chromatography-electrospray system are disclosed. The droplet/electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate droplets or an electrospray. A plurality of these electrospray devices can be used in the form of an array of miniaturized nozzles. The liquid chromatography-electrospray device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow.