Abstract: A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

Abstract: A technique facilitates deployment and operation of a pumping system, e.g. an electric submersible pumping system, in a borehole. A locking and sealing mechanism, e.g. a spring-loaded locking sealing mechanism, may be coupled with the pumping system and comprises an anchoring section along with a sealing section. The locking sealing mechanism may be constructed for deployment with the pumping system via a running tool. Once in position downhole, the anchoring section and the sealing section may be actuated into sealing engagement with the interior surface of a surrounding tubing. At this stage, production of a desired fluid may be accomplished by operating the pumping system.

Abstract: A SI-traceable Rydberg atom radiofrequency power meter determines power of reference radiofrequency radiation and includes: a reference radiofrequency source that provides reference radiofrequency radiation; a vapor cell including: a pair of parallel-plate waveguides; a vapor cell wall including parallel opposing faces of the parallel-plate waveguides; and the vapor space physically bounded by the vapor cell wall to contain gas atoms in an optical overlap volume; and a transmission detector that receives the output light from the vapor cell and produces a transmission signal from the transmission detector for determination of power of the reference radiofrequency radiation, wherein the SI-traceable Rydberg atom radiofrequency power meter determines power of the reference radiofrequency radiation by electromagnetically induced transparency of the gas atoms in a Rydberg electronic state, the determination of power being traceable to the International System of Units (SI).

Abstract: A technique facilitates deployment and operation of a pumping system, e.g. an electric submersible pumping system, in a borehole. A locking and sealing mechanism, e.g. a spring-loaded locking sealing mechanism, may be coupled with the pumping system and comprises an anchoring section along with a sealing section. The locking sealing mechanism may be constructed for deployment with the pumping system via a running tool. Once in position downhole, the anchoring section and the sealing section may be actuated into sealing engagement with the interior surface of a surrounding tubing. At this stage, production of a desired fluid may be accomplished by operating the pumping system.

Abstract: A portable pill dispenser is disclosed herein. The portable pill dispenser includes a container configured to house at least one pill therein. The container is attachable to a housing, which comprises a dispensing opening. A dispensing mechanism, a ramp, and a control panel are disposed within the housing. The dispensing mechanism is configured to dispense the at least one pill from the container to the dispensing opening. The ramp is configured to direct the at least one pill to the dispensing mechanism. A verification mechanism is disposed about the housing. The verification mechanism is configured to activate the dispensing mechanism. The control panel is in electrical communication with the dispensing mechanism and the verification mechanism.

Abstract: A SI-traceable Rydberg atom radiofrequency power meter determines power of reference radiofrequency radiation and includes: a reference radiofrequency source that provides reference radiofrequency radiation; a vapor cell including: a pair of parallel-plate waveguides; a vapor cell wall including parallel opposing faces of the parallel-plate waveguides; and the vapor space physically bounded by the vapor cell wall to contain gas atoms in an optical overlap volume; and a transmission detector that receives the output light from the vapor cell and produces a transmission signal from the transmission detector for determination of power of the reference radiofrequency radiation, wherein the SI-traceable Rydberg atom radiofrequency power meter determines power of the reference radiofrequency radiation by electromagnetically induced transparency of the gas atoms in a Rydberg electronic state, the determination of power being traceable to the International System of Units (SI).

Abstract: A portable pill dispenser is disclosed herein. The portable pill dispenser includes a container configured to house at least one pill therein. The container is attachable to a housing, which comprises a dispensing opening. A dispensing mechanism, a ramp, and a control panel are disposed within the housing. The dispensing mechanism is configured to dispense the at least one pill from the container to the dispensing opening. The ramp is configured to direct the at least one pill to the dispensing mechanism. A verification mechanism is disposed about the housing. The verification mechanism is configured to activate the dispensing mechanism. The control panel is in electrical communication with the dispensing mechanism and the verification mechanism.

Abstract: A method of managing risk associated with at least one compromised network asset, comprising: performing processing associated with receiving evidence regarding the at least one compromised network asset; performing processing associated with assessing at least one risk associated with the at least one compromised network asset; and/or performing processing associated with prioritizing at least two compromised network assets in order to determine how to respond to the at least one risk.

Abstract: A method of managing risk associated with at least one compromised network asset, comprising: performing processing associated with receiving evidence regarding the at least one compromised network asset; performing processing associated with assessing at least one risk associated with the at least one compromised network asset; and/or performing processing associated with prioritizing at least two compromised network assets in order to determine how to respond to the at least one risk.

Abstract: The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.

Abstract: Methods of reducing aggregation of a protein or proteins in a formulation, and protein formulations having reduced aggregation properties are provided. The methods and formulations described herein maintain the biological activity of a protein and increase the shelf life of protein formulations.

Abstract: The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.

Abstract: A method for bleaching wood fibers with a mixture of sodium borohydride and sodium bisulfite followed by peroxide bleaching in the same vessel.

Abstract: An apparatus, program product and method for managing a number of physical connections to a peripheral device. A multipath driver provides a logical connection interface to a client. This interface allows the client to efficiently access the peripheral device over one or more of the physical connections. In so doing, the logical connection interface associates connections with a primary connection, deletes inactive connections from memory, as well as updates and uses a list of active connections to seamlessly route data to the peripheral device.

Abstract: An apparatus and method provides the capability of mirroring storage between geographically remote locations in an asynchronous manner that does not require all writes on primary storage to be performed in the same order on the mirrored storage. The mirroring of the present invention is “logical mirroring”, which does not require identical disk drives, and which supports mirroring between geographically remote locations to protect against catastrophic site failure. A sequence number is assigned to data written to primary storage before the data is transferred to the mirrored storage. The mirrored storage can write data asynchronously, which may result in some data being written before previous data on the mirrored storage. When a system failure occurs that requires use of the mirrored storage, the mirrored storage is first quiesced to allow all pending writes to occur.

Abstract: A hand-holdable structure implementing electrodes to enable good skin-electrode contact to acquire ECG readings is disclosed. Specifically, the structure is shaped to enable patients to apply a simple gentle grip to have a reliable skin-electrode contact and to automatically commence ECG tracing transmission to a patient monitoring station. In one embodiment the structure incorporates an RF telemetry head to simultaneously transfer IMD stored data in conjunction with the ECG tracings. The structure independently or in combination with the RF telemetry head is adaptable to a system of data communications with a programmer or equivalent instrument to transfer ECG and IMD data to a remotely located physician station or patient data storage server. The system is also adaptable for use with a web-enabled network such as, without limitation, the Internet, intranet, World Wide Web, extranet or equivalent.

Abstract: A hand-holdable structure implementing electrodes to enable good skin-electrode contact to acquire ECG readings is disclosed. Specifically, the structure is shaped to enable patients to apply a simple gentle grip to have a reliable skin-electrode contact and to automatically commence ECG tracing transmission to a patient monitoring station. In one embodiment the structure incorporates an RF telemetry head to simultaneously transfer IMD stored data in conjunction with the ECG tracings. The structure independently or in combination with the RF telemetry head is adaptable to a system of data communications with a programmer or equivalent instrument to transfer ECG and IMD data to a remotely located physician station or patient data storage server. The system is also adaptable for use with a web-enabled network such as, without limitation, the Internet, intranet, World Wide Web, extranet or equivalent.

Abstract: A standoff for mounting two or more printed circuit boards to a chassis in which one keyhole cut printed circuit board may be slidably mounted on the keyhole mount of the standoff and a second printed circuit board may be mounted on the top portion of the standoff spaced away from the first printed circuit board. The second printed circuit board may be affixed to the standoff by either a screw mount, snap lock mount, adhesive, bolt and nut, clamp or other method.