Abstract: The present invention relates to antibodies binding to IL13 and IL22. The invention provides novel multi-specific antibodies that bind to both IL13 and IL22 and compositions comprising an antibody that binds to IL13 and an antibody that binds to IL22. The invention further relates to therapeutic uses of the combination of anti-IL13 and anti-IL22 antibodies and multi-specific antibodies that bind to both IL13 and IL22.

Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.

Abstract: A turbine engine includes a compressor section, a combustion section, and a turbine section, and an airfoil with an outer wall defining a pressure side and a suction side and extending between a leading edge and a trailing edge to define a mean camber line. A first thickness is defined between the pressure side and the suction side at a first location along the mean camber line.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: A method of data storage includes determining a latency distance from a primary node to each of two or more replica nodes, choosing a preferred replica node of the two or more replica nodes based on the determined latency distances, and write-caching data into the preferred replica node.

Abstract: The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2, R3, R4, n, Lk, (A), G and m are as defined herein. Also provided are therapeutic uses of such combinations and compositions in the treatment of conditions such as cystic fibrosis.

Abstract: A user equipment (UE) in a wireless communication system. The UE comprises at least one processor configured to determine a first subcarrier spacing and a transceiver configured to transmit, to a base station (BS), random access signals generated with the first subcarrier spacing and receive a downlink control signaling comprising a physical (PHY) resource configuration that includes a second subcarrier spacing. The UE further comprises at least one processor configured to set the PHY resource configuration for at least one of uplink transmission or downlink reception.

Abstract: A computer system and method for generating non-fungible tokens (NFTs) representing a company asset based on evaluation of company assets (e.g., a hospital). Stored in a database are one or more digital assets (e.g., one or more of settlement rights and insurance claim payment obligations) representative of contractual obligations owed to the company (e.g., settlement rights), which are then analyze to determine one or more assets owed to the company. A valuation value is then determined for the determined one or more assets. NFTs are then generated based on the determined valuation value of the determined one or more assets. Additionally, the generated NFTs may be leveraged as collateral in an underwriting process. Further, analyzed in real-time, is a revenue cycle management of the company for generating a risk-weighted index value indicative of the revenue cycle management.

Abstract: A method of data storage includes determining a latency distance from a primary node to each of two or more replica nodes, choosing a preferred replica node of the two or more replica nodes based on the determined latency distances, and write-caching data into the preferred replica node.

Abstract: A lateral flow test kit includes a cassette and a swab. The cassette comprises a vial of liquid closed by seal; a test strip; a passage leading from the exterior of the cassette to the vial; and a conduit communicating between the vial and the test strip. The swab can be inserted along the passage to cause a tip of the swab to enter the vial and release liquid from the vial. The liquid flows past a head of the swab to extract a sample and deliver it through the conduit 34 to the test strip. The passage may comprise an obstruction, which requires the user to push the swab past it with a force sufficient to penetrate the seal. The obstruction may also prevent removal of the used swab from the cassette. A distal end of the passage may be curved to deflect the tip of the swab towards the seal at a more favourable angle.

Abstract: A system for dispensing a detergent solution from a solid detergent into a dishwasher includes a dispenser that can collect water sprayed into the dishwasher and use the collected water to produce the detergent solution by dissolving a portion of the solid detergent, controlling the amount of the detergent solution produced, and releasing the produced detergent solution between cleaning cycles. The dispenser can perform these functions automatically without being electrically powered.

Abstract: Various implementations include audio devices such as earbuds or earpieces. In certain cases, an audio devices includes a set of earbuds configured to generate a magnetic field. The audio device also includes a case for docking the set of earbuds. The case includes: a Hall effect sensor for detecting proximity to at least one of the earbuds based on the magnetic field; and a power source for charging the set of earbuds while docked in the case. Additional implementations include independent couplings for earbuds or earpieces.

Abstract: A system for dispensing a detergent solution from a solid detergent into a dishwasher includes a dispenser that can collect water sprayed into the dishwasher and use the collected water to produce the detergent solution by dissolving a portion of the solid detergent, controlling the amount of the detergent solution produced, and releasing the produced detergent solution between cleaning cycles. The dispenser can perform these functions automatically without being electrically powered.

Abstract: An elastic nonwoven material includes a first non-woven fabric including a plurality of rows. Each row has a plurality of adjacent bonds formed therein. The elastic nonwoven material also includes a first elastic strand entrapped between a first pair of adjacent bonds within a first row of the plurality of rows, and a second elastic strand entrapped between a second pair of adjacent bonds within the first row. A third pair of adjacent bonds within the first row is free of elastic material therebetween and is located between the first pair of adjacent bonds and the second pair of adjacent bonds.

Abstract: A user equipment (UE) and base station (BS) in a wireless communication network. The UE includes a receiver configured to receive at least one semi-persistent scheduling (SPS) configuration among a plurality of SPS configurations from a BS. Each of the SPS configurations configures the UE with a different periodicity of a sidelink transmission to be transmitted to another UE. The UE also includes a transmitter configured to transmit the sidelink transmission in the different periodicity according to the at least one of the plurality of SPS configurations. The BS includes a controller configured to select at least one SPS configuration among a plurality of SPS configurations for a UE. Each of the SPS configurations configures the UE with a different periodicity of a sidelink transmission to be transmitted to another UE. The BS also includes a transmitter configured to transmit the selected at least one SPS configuration to the UE.

Abstract: Network-assisted device discovery includes initiating the D2D network-assisted device discovery of a receiving UE to enable a target UE and the receiving UE to establish a D2D communication. A discovery feasibility measurement is performed to determine whether a D2D communication between the target UE and the receiving UE is feasible. A discovery setup message is transmitted and a discovery report is received from the target UE.

Abstract: Establishment of integrated links comprising integrated wireless backhaul communications links and access communications links is facilitated by transmitting multiplexed sync signals to enable synchronization between the relay transmission point devices, and using a random access channel procedure to complete the establishment. The integrated wireless backhaul communications links and access communications links can be maintained by measuring channel characteristics of the backhaul communications links using a measurement reference signal.

Abstract: Systems and methods are provided for interacting with an Application Programming Interface (API) using a digital signature. In one embodiment, a system includes one or more processors that execute the instructions to perform operations. The operations may include receiving a first digital signature from a requesting device, the first digital signature being associated with a first set of fields in the database; identifying one or more requested fields; accessing the database to retrieve the information associated with the one or more requested fields, the information being associated with at least one API; and providing a response to the requesting device to cause a requesting application to consume the response from the API.

Abstract: An article for use with an apparatus for heating aerosol generating agent to volatilize at least one component of the aerosol generating agent, the article including a support layer having a first surface, wherein at least a portion of the first surface is rough and an aerosol generating agent on the portion of the first surface that is rough.

Abstract: An apparatus for determining a characteristic of a material within a region comprises a first plurality of electrodes disposed within or about the region, an energisation source arranged to apply an applied stimulation signal to at least one of said first plurality of electrodes, a stimulation monitor arranged to monitor an electrical parameter at a second plurality of said first plurality of electrodes in response to said applied stimulation signal, the stimulation monitor being configured to generate a received stimulation signal for each of said second plurality of electrodes, a monitor configured to generate a series of data values, each data value being indicative of a phase difference and/or an amplitude relationship between the applied stimulation signal and a received stimulation signal associated with one of the second plurality of electrodes, said series of data values defining an electromagnetic fingerprint, and a controller configured to: receive the electromagnetic fingerprint, identify an interr