Abstract: Disclosed are methods and systems to detect a class of non-variola Orthopoxviruses, and, more particularly, monkeypox virus. In certain embodiments, the method may comprise obtaining a sample from the subject; and detecting a nucleic acid sequence specific to the non-variola Orthopoxvirus. In some embodiments, the method may further isolation of the non-variola Orthopoxvirus from a solid substrate such as a tissue swab and further purification of viral nucleic acid using silica beads. The sample may in some cases be self-collected by a subject. The disclosed methods and systems, including kits for self-collection, may be used for a high throughput assay allowing for screening of hundreds of samples per day.

Abstract: A cover for a container that includes a lid portion and a collar element. The lid portion having a main body section surrounded by a peripheral sealing shoulder. The collar element having a peripheral collar sealing shoulder that includes a collar groove and wherein the lid portion is connected to the collar portion through a hinge element. The lid portion, collar element and hinge portion are formed as a unitary structure and the lid portion articulates from an open positon in which it is spaced apart from the collar element to a closed position wherein the peripheral bead sealing shoulder of the lid portion engages with the peripheral collar sealing shoulder of the collar element.

Abstract: In various embodiments, a workflow application generates and evaluates designs that reflect stylistic preferences. In operation, the workflow application determines a target style based on input received via a graphical user interface (GUI). Notably, the target style characterizes a first set of designs. The workflow application then generates stylized design(s) based on stylization algorithm(s) associated with the target style. Subsequently, the workflow application, displays a subset of the stylized design(s) via the GUI. A stylized design included in the subset of stylized design(s) is ultimately selected for production via the GUI. Advantageously, because the workflow application can substantially increase the number of designs that can be generated and evaluated based on the target style in a given amount of time, relative to more manual prior art techniques, the overall quality of the stylized design selected for production can be improved.

Abstract: The present disclosure is generally directed to an anucleated cell-based platforms for encapsulation and delivery of agricultural compounds. Disclosed herein are compositions for the stable and targeted delivery of agricultural compounds within achromosomal and/or anucleated cells. The present disclosure also provides methods of improving encapsulation and retention of agricultural compounds in achromosomal and/or anucleated cells.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: The present disclosure is generally directed to an agricultural formulation comprising an anucleated minicells and an anucleated cell-based platforms for encapsulation and scalable delivery of biologically active compounds. Disclosed herein are compositions for the stable and targeted delivery of biologically active compounds within achromosomal and/or anucleated cells onto and/or into a target cell. The present disclosure also provides methods of improving encapsulation and retention of biologically active compounds in achromosomal and/or anucleated cells and delivering biologically active compounds into a target cell.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: New breeder blanket designs and configurations for use in a nuclear fusion reactor to breed Tritium fuel are presented. The breeder blanket designs consist of steel conduits made of different sections, formed of different steels, which are used for the circulation of liquid breeder material.

Abstract: A variable length headless compression screw insertion system includes a compression screw and a driver assembly for driving the compression screw into a bone. The compression screw has a bone screw and a compression sleeve coupled to the bone screw. The bone screw includes a proximal end having an external threading threadably received in the compression sleeve, and the compression sleeve includes a proximal end having a predefined drive feature and an external threading. The driver assembly includes a sleeve coupler adapted to threadably receive the external threading of the compression sleeve. A ram driver is coupled to the sleeve coupler and has a predetermined length such that its distal end is shaped to contact the proximal end of the bone screw to prevent translation of the bone screw relative to the compression sleeve.

Abstract: One embodiment of the present invention sets forth a technique for generating a layout for a building. The technique includes determining a space occupied by the building and one or more rules associated with one or more example building layouts. The technique also includes iteratively assigning one or more sets of cells within the space to one or more building modules based on the one or more rules, where the one or more building modules represent one or more types of interior space within the building. The technique further includes generating the layout for the building based on the one or more sets of cells assigned to the one or more building modules.

Abstract: One embodiment of the present invention sets forth a technique for generating a modular design for a construction project. The technique includes executing generating a plurality of design options for the construction project, where each design option includes a site layout and a set of building designs for a set of buildings included in the site layout. The technique also includes computing a first set of performance metrics for the site layout associated with each design option and a second set of performance metrics for the set of building designs associated with each design option, and aggregating the first and second sets of performance metrics into a set of overall performance metrics for each design option. The technique further includes generating a set of candidate designs for the construction project based on the plurality of design options and the overall performance metrics associated with the plurality of design options.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: Devices, systems, and methods for bone stabilization, especially proximal humeral stabilization. The stabilization system may include a bone plate having an elongated portion extending along a longitudinal axis and an enlarged head portion extending from the elongated portion. The stabilization system may include an intramedullary nail having an upper portion and a lower portion extending from the upper portion, the upper portion and the lower portion including a plurality of holes. A plurality of fasteners may be configured to extend through one or more of the plurality of through holes in the bone plate and/or one or more of the plurality of holes in the intramedullary nail and into the bone. The plate and nail may each be used alone or in combination together to stabilize a fracture in a long bone, such as a humerus.

Abstract: The present disclosure is generally directed to an agricultural formulation comprising an anucleated minicells and an anucleated cell-based platforms for encapsulation and scalable delivery of biologically active compounds. Disclosed herein are compositions for the stable and targeted delivery of biologically active compounds within achromosomal and/or anucleated cells onto and/or into a target cell. The present disclosure also provides methods of improving encapsulation and retention of biologically active compounds in achromosomal and/or anucleated cells and delivering biologically active compounds into a target cell.

Abstract: Disclosed herein are system, method, and computer program product embodiments for adjusting a transmission field-of-view (Tx FoV). For example, the system includes a lidar sensor with a series of emitters. Each emitter is configured to transmit light pulses away from a vehicle along a transmission axis to form a transmission field-of-view (Tx FoV). At least one detector is configured to receive at least a portion of the light pulses that reflect off of an object within a reception field-of-view (Rx FoV) along a reception axis. A transmit optic is mounted for translation along a transverse axis and configured to intersect each transmission axis without intersecting the reception axis to adjust the Tx FoV without adjusting the Rx FoV.

Abstract: A method and system for causing a call leg transition based on determining that a screen of a device is not viewable to a user are disclosed, comprising receiving, using a default first telephony application, an incoming call event having a first call leg over a first connection to a telecommunication network addressed to the device, accepting the incoming call event using a second telephony application, creating a second connection having a second call leg to the telecommunication network corresponding to the incoming call event, associating a call event continuity identifier unique to the incoming call event with each of the first and second call legs so that the first and second call legs are connectable at a common port in the telecommunication network, determining if the screen of the device is viewable to the user, and causing a transition from the second call leg to the first call leg based on determining that the screen of the device is not viewable to the user.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; a manifold assembly including a rigid manifold having first and second chambers (110a, 110b), the rigid manifold configured and arranged to be abutted against the actuation surface for operation, a peristaltic pump tube (124gh) extending from the first chamber (110a) to the second chamber (110b) of the rigid manifold, a dialysis fluid container line (124b) extending from the first chamber (110a), and a branch line (124c) extending between the dialysis fluid container line (124b) and the second chamber (110b); and a control unit configured to cause the peristaltic pump actuator to actuate the peristaltic pump tube (124gh) to pump dialysis fluid from the branch line (124c) into the second chamber (110b) and from the second chamber (110b) into the first chamber (110a).

Abstract: Neutron shielding comprising a metal-hydride metal composite: the metal-hydride metal composite comprising: a metal matrix; and a plurality of metal-hydride particles dispersed within the metal matrix; wherein, the fraction of metal-hydride in the metal-hydride metal composite is at least 1 mol % and the volume fraction of metal-hydride in the metal hydride metal composite is no higher than the ratio of the solid solubility limit of hydrogen in the metal matrix and the molar fraction of hydrogen in the metal-hydride.