Abstract: The present invention relates generally to vitamin 12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: The present invention relates to a method for transdermal drug delivery of insoluble drugs, especially those with severe side effects. It also relates to a new use for the drug Carafate®. Specifically, the present invention describes a method for delivering insoluble drugs transdermally by making a suspension of the powdered form of the drug in an isotonic solution. Drugs which can be delivered by this method include nonsteroidal anti-inflammatory drugs (NSAIDs), Vioxx®, Celebrex®, Accutane®, and Carafate®. The invention also describes a solution of a powdered form of Carafate® in an isotonic solution, which can then be used to treat conditions such as acne, herpes simplex II cold sores, root canal wounds, and dry sockets after teeth have been removed.

Abstract: The present invention relates to the prevention and treatment of atopic dermatitis and treatment of atopic dermatitis and other eczematous disorders by application of topical mast cell stabilizers including cromolyn sodium, nedocromil or lodoxamide, in a vehicle of a buffered isotonic saline solution (OCEAN®).

Abstract: A guide wire tip including a core wire having a proximal end and a distal end. The core wire includes a tapered portion proximate the distal end. The tapered portion has a transverse, cross-sectional area which generally decreases distally. The tip is disposed at the distal end of the core wire. The tip has a transverse, cross-sectional area larger than the smallest transverse cross-sectional area of the tapered portion of the core wire. A coil extends over the core wire to the tip. The coil extends over at least a portion of the tapered portion. A radiopaque sheath is disposed proximate the tip and between the core wire and the coil.

Abstract: A guide wire tip including a core wire having a proximal end and a distal end. The core wire includes a tapered portion proximate the distal end. The tapered portion has a transverse, cross-sectional area which generally decreases distally. The tip is disposed at the distal end of the core wire. The tip has a transverse, cross-sectional area larger than the smallest transverse cross-sectional area of the tapered portion of the core wire. A coil extends over the core wire to the tip. The coil extends over at least a portion of the tapered portion. A radiopaque sheath is disposed proximate the tip and between the core wire and the coil.

Abstract: A guidewire having an intermediate flexibility region to provide trackability and steerability while reducing guide catheter device back out. In one embodiment, the guidewire includes a distal flexibility region, intermediate flexibility region and proximal flexibility region. The intermediate or support flexibility region preferably extends from between about 3 cm to 40 cm proximally of the distal tip. The intermediate region is divided into at least two sections of varying stiffness.

Abstract: The present invention relates to compositions and methods for the prevention and/or treatment of allergic, autoimmune, septic shock or infectious diseases using magnesium gluconate alone or in combination with one or more antioxidants or an antiinflammatory agent. The invention also relates to the inhibition of production of inappropriate levels of lipid mediators and cytokines.

Abstract: The present invention relates to methods and compositions for the prevention and/or treatment of exercise-induced muscle cramps, stiffness, pain or spasms, using magnesium gluconate alone or in combination with one or more antioxidants or conventional pharmacologic therapy. The invention also relates to inhibition of production of oxygenated molecules, oxygen free radicals and lipid peroxidation.

Abstract: The present invention relates to methods and compositions for the prevention and/or treatment of diabetes mellitus, using magnesium gluconate alone or in combination with one or more antioxidants or conventional diet and/or insulin therapy. The invention also relates to inhibition of production of oxygen free radicals and lipid peroxidation.

Abstract: A tool, for placement of predetermined amounts of granular fertilizer into the soil in a consolidated mass, provides an elongate body with a handle structure in its upper portion and a tubular fertilizer reservoir in its lower portion. The fertilizer reservoir defines an open upper portion for filling and slidably carries an associated tube for adjustment of the volume of a fertilizer charge. An angulated bottom portion of the reservoir allows insertion into the earth and carries a pivotally articulated cover to allow opening of the bottom portion of the reservoir for dispersement of a fertilizer charge. The lower medial portion of the tool body provides a pivotally mounted foot support to aid insertion of the fertilizer reservoir into the earth. Dispersement structure communicates from the pivotally articulated reservoir cover to the handle structure for opening of the cover from the handle area for dispersement of fertilizer.

Abstract: A tool to releasably engage in a channel of a concrete block for lifting provides an elongate body rod defining a fastening loop in its upper portion and carrying in its lower portion two radially extending fins having an obtuse central angle less than a straight angle therebetween. Each fin pivotally supports vertically spaced, parallel connector links that pivotally interconnect vertically orientated fastening arms for similar radial motion. The body provides at least one fixed fastening arm extending on a line bisecting the central angle between the two fins. Release mechanism provides a release collar slidable on the body between the fins and fastening ring. The collar pivotally carries connector links that interconnect with the upper fastening arms to radially move the fastening arm responsive to collar motion. A compression spring carried about the body rod between the collar and the fastening ring biases the collar downwardly and responsively the fastening arms outwardly.