Patents by Inventor Thomas E. Karplus

Thomas E. Karplus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing bacterial endotoxin contamination in solutions of macromolecules
    Patent number: 4808314
    Abstract: The present invention contemplates a method of reducing a bacterial endotoxin contaminant in a biologically useful macromolecule. AN aqueous medium containing an endotoxin-contaminated macromolecule is admixed with a dialyzable surfactant, and the admixture so formed is contacted with an endotoxin sorbant to form a solid-liquid phase admixture. The contacting is maintained until the endotoxin is bound to the sorbant. The surfactant is dialyzed out of the aqueous liquid phase at a time no earlier than the maintenance step. The liquid phase containing the macromolecule is separated and recovered.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: February 28, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Thomas E. Karplus, Richard J. Ulevitch, Curtis B. Wilson