Abstract: Within methods and systems for computer-aided optimization of process models, defined specifications and associated release criteria (quality gates) are available for every work stage. The specifications include service documents, result features that are to be generated in a work stage, and budget details and the latest end time for a work stage. The release criteria (quality gates) can identify the results of a work stage as successful and can assess the fulfillment of a work stage. A reference for all work stages simulates the model based on a fictitious sample project, interference variables are introduced, the project implementation is simulated for each interference variable, respectively, the deviations from the reference run are automatically determined, respectively, for each interference variable, and an analysis of the influence of the release criteria (quality gates) regarding compliance with the budget and the schedule is performed based on the determined deviations from the reference run.

Abstract: A module for processing a biological sample for an analysis test is disclosed. The processing module includes, in at least one embodiment, an interface at which the processing module can be connected to a cartridge with a lab-on-a-chip, in which cartridge the analysis steps are carried out. A biochip kit is also disclosed. In at least one embodiment, the biochip kit includes one or more processing modules which are intended for different sample materials and which can be connected to the same cartridge type.

Abstract: An apparatus is disclosed for processing a sample which stores processing reagents required for processing in a dry form. The processing reagents are covered by a biologically degradable medium or embedded in said biologically degradable medium.

Abstract: A device and a method are disclosed for the detection and/or for the quantification of an analyte. In at least one embodiment, the device includes a basic matrix and magnetized nanoparticles, which are arranged in moveable fashion in or at the basic matrix and to which catcher molecules that bind specifically to the analyte are anchored. Further, the mobility of the nanoparticle in the basic matrix can be influenced by a binding of the analyte to be detected to the catcher molecules and can be read out magnetically.

Abstract: A toothed gear wheel with toothed wheel body and exchangeable teeth is disclosed. One or more teeth are embodied as a component which is able to be detachably connected to the toothed wheel body of the toothed gear wheel. A transmission embodied with the toothed gear wheel is disclosed. A component with suitable for use in a toothed gear wheel with toothed wheel body is also disclosed.

Abstract: A method or a software application which is used to assign artifacts of technical systems to the process steps required to produce them, wherein the assignments comprise annotations, and the method provides an editor for the annotations. A graphical user interface is also provided, which can be used to visualize the artifacts (e.g., documents describing structural elements) of the technical system and individual process steps (or entire process cycles) and to input the annotations between the two in graphical or tabular form and process them. Pre-existing special knowledge in the domain and the craft relating to plant engineering is acquired, processed, preserved and imparted using the method of the invention. The method advantageously provides effective support for document and configuration management, where CAD and project management tools are integrated to give a systematic IT landscape without media clashes.

Abstract: Methods and engineering systems for the automatic inspection of the modeling of technical systems in an engineering or design process, wherein the used description language (e.g., UML or SysML) is extended by suitably defined stereotypes, especially suitable for the automatic detection of incompatibilities in the formation or variants of technical systems or products.

Abstract: Within methods and systems for computer-aided optimization of process models, defined specifications and associated release criteria (quality gates) are available for every work stage. The specifications include service documents, result features that are to be generated in a work stage, and budget details and the latest end time for a work stage. The release criteria (quality gates) can identify the results of a work stage as successful and can assess the fulfillment of a work stage. A reference for all work stages simulates the model based on a fictitious sample project, interference variables are introduced, the project implementation is simulated for each interference variable, respectively, the deviations from the reference run are automatically determined, respectively, for each interference variable, and an analysis of the influence of the release criteria (quality gates) regarding compliance with the budget and the schedule is performed based on the determined deviations from the reference run.

Abstract: An arrangement is provided in at least one embodiment, having a magazine for supplying a plurality of microfluidic devices. The microfluidic devices each contain at least one element/device for binding at least one biological molecule, wherein the at least one element/device for binding the at least one biological molecule can be moved relative to the microfluidic device. A sample presumably containing biological molecules to be examined is introduced into the microfluidic device. The biological molecule to be examined is bound by the at least one element/device for binding the biological molecule. In at least one embodiment, the at least one element/device for binding the at least one biological molecule, or the substrate-molecule complex, can then be moved in the microfluidic device, e.g. in accordance with a predetermined reaction sequence, for example by means of a magnetic field. The microfluidic device is transported through the arrangement.

Abstract: A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from the cavity through at least one liquid discharge connected to the cavity.

Abstract: An apparatus is disclosed for displaying a tissue containing a fluorescent dye at least in sections. It is proposed for the purpose of simplification to record the tissue with a number of cameras from different observation angles while omitting a beam splitter, and subsequently to produce a joint superimposed overall image.

Abstract: A central data server provides data of objects and/or object types. The data are configured as metadata which characterise content available at a site arranged outside a memory of the data server. The data have a validity range and/or a solution space. The contents are uniform within the validity range and/or solution space and are valid for all participants. The data server supplies meta-information in response to a query.

Abstract: Oligonucleotide arrangements are disclosed which, in each case, have at least two oligonucleotide sequences linked via at least one spacer. A process is disclosed using the oligonucleotide arrangements for the amplification and/or detection of nucleic acid sequences with formation of crosslinked conglomerates. The process can be used, for example, for the sensitive, simple and inexpensive detection of nucleic acid sequences.

Abstract: An embodiment of the present invention relates to a carrier material which is used in a method of diagnosis and which comprises a base material which is provided with a surface which is equipped with at least two different affinity ligands.

Abstract: A method is disclosed for identifying nucleotide sequences while using non-labeled free oligonucleotides, labeled free and hybridizable oligonucleotides and non-labeled and immobilized oligonucleotides.

Abstract: A device and method are disclosed for preparing a sample for an analysis and a device and method are disclosed for analyzing a sample. In at least one embodiment, a device is disclosed for preparing a sample for analysis including means for binding at lest one biological structure of the sample, means for releasing at least one biological molecule contained in the at least one structure, and means for binding the at least one released molecule. The means for binding the at least one structure and the means for binding the at least one molecule can move.

Abstract: A method is disclosed for displaying a tissue containing a fluorescent dye at least in sections. In order to reduce interference signals, it is proposed to record a first fluorescent image during an illumination phase, and a second fluorescent image during a dark phase, and to correct the first fluorescent image by subtracting the second fluorescent image and to process it subsequently to form an overall image.

Abstract: A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from the cavity through at least one liquid discharge connected to the cavity.

Abstract: An apparatus is disclosed for processing a sample which stores processing reagents required for processing in a dry form. The processing reagents are covered by a biologically degradable medium or embedded in said biologically degradable medium.

Abstract: At least one embodiment of the present invention relates to analytical systems based on porous material, for example silicon, for highly parallel single cell detection. At least one embodiment of the present invention relates in particular to porous silicon having a multiplicity of continuous channels and/or to the use thereof at least for cell separation, for cell lysis and purification of target molecules, for amplification of nucleic acid molecules or for detection of desired target molecules. At least one embodiment of the present invention also relates to an analytical method using porous silicon. Monoclonal antibodies for cell separation and immobilized capture molecules for cell lysis and purification are attached to the inside walls of the channels.