Patents by Inventor Thomas Erdenberger
Thomas Erdenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11644349Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.Type: GrantFiled: October 23, 2020Date of Patent: May 9, 2023Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
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Publication number: 20220033755Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.Type: ApplicationFiled: September 7, 2021Publication date: February 3, 2022Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: COLIN TUOHEY, THOMAS ERDENBERGER, RICHARD DAMREN, MICHAEL FISHER, JOHN SWIBES
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Patent number: 11142737Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.Type: GrantFiled: February 22, 2012Date of Patent: October 12, 2021Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Colin Tuohey, Thomas Erdenberger, Richard Damren, Michael Fisher, John Swibes
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Publication number: 20210041272Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.Type: ApplicationFiled: October 23, 2020Publication date: February 11, 2021Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: RICHARD L. DAMREN, COLIN R. TUOHEY, THOMAS ERDENBERGER, MICHAEL FISHER, JONATHAN A. KENNEY, PARRISH M. GALLIHER, JOSEPH D. CROWELL
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Patent number: 10859412Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.Type: GrantFiled: January 3, 2018Date of Patent: December 8, 2020Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
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Patent number: 10857510Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: GrantFiled: April 11, 2016Date of Patent: December 8, 2020Assignee: Global Life Sciences Solutions USA LLCInventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
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Patent number: 10792618Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.Type: GrantFiled: June 19, 2018Date of Patent: October 6, 2020Assignee: Sartorius Stedim Biotech GmbHInventor: Thomas Erdenberger
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Patent number: 10774299Abstract: Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.Type: GrantFiled: November 8, 2016Date of Patent: September 15, 2020Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Parrish M. Galliher, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Richard L. Damren
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Patent number: 10767154Abstract: A heat exchange module for use in a chemical, pharmaceutical or biological reactor system includes a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable reactant container to facilitate heat transfer, a fluid circulation path formed within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated, and at least one baffle protruding from the inner wall of the body into the interior space.Type: GrantFiled: April 14, 2016Date of Patent: September 8, 2020Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard L. Damren, Thomas Erdenberger, Colin R. Tuohey, Joseph D. Crowell, Parrish M. Galliher, Kenneth P Clapp, Peter A. Mitchell
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Publication number: 20190381457Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.Type: ApplicationFiled: June 19, 2018Publication date: December 19, 2019Inventor: Thomas Erdenberger
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Patent number: 10442674Abstract: Disclosed herein are embodiments of a valve assembly for preventing dead leg spaces in a container or tubing, the embodiments including a three-way valve system for controlling back-pressure in a fluid generating device, such as a single-use high pressure bioreactor. Also disclosed is a pressurized reactor system for bioprocessing, comprising a single-use container including a flexible wall or a semi-rigid wall.Type: GrantFiled: July 29, 2016Date of Patent: October 15, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin R. Tuohey, Thomas Erdenberger, Richard L. Damren, Kenneth Clapp, Parrish M. Galliher, Jonathan Kenney
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Patent number: 10221383Abstract: A system for condensing moisture in a moist gas stream entering or leaving a bioreactor includes a condenser container, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding a fluid; and a first fitment attached to the outer wall surface and forming a first port configured to allow the moist gas stream to flow into the interior chamber; a second fitment attached to the outer wall surface and forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface and arranged to cool the at least one portion of the outer wall surface.Type: GrantFiled: September 8, 2016Date of Patent: March 5, 2019Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard Damren, Colin Touhey, Thomas Erdenberger, Michael Fisher, Geoffrey Hodge, Patrick Guertin, Parrish Galliher
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Publication number: 20180237736Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bio culture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant.Type: ApplicationFiled: April 17, 2018Publication date: August 23, 2018Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: COLIN TUOHEY, TED DELOGGIO, THOMAS ERDENBERGER, KENNETH P. CLAPP, RICHARD DAMREN, PARRISH M. GALLIHER, PATRICK GUERTIN, JIYOUNG LEE, MICHAEL FISHER
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Publication number: 20180143042Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid object is provided. The probe assembly includes an aseptic connector for coupling to the object, a probe sheath that extends longitudinally from the aseptic connector, and an actuator for deploying the probe within the object. The probe sheath has a plurality of concentric sheath elements and an inner longitudinal volume that is configured to permit longitudinal movement of the probe within the probe sheath. The actuator moves the probe longitudinally within the probe sheath by telescoping a first sheath element of the plurality within another sheath element of the plurality such that the probe is moved to a position sufficient to measure at least one parameter within the object.Type: ApplicationFiled: January 3, 2018Publication date: May 24, 2018Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: RICHARD L. DAMREN, COLIN R. TUOHEY, THOMAS ERDENBERGER, MICHAEL FISHER, JONATHAN A. KENNEY, PARRISH M. GALLIHER, JOSEPH D. CROWELL
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Patent number: 9969965Abstract: Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis.Type: GrantFiled: January 11, 2012Date of Patent: May 15, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Colin Tuohey, Ted Deloggio, Thomas Erdenberger, Kenneth P. Clapp, Richard Damren, Parrish M. Galliher, Patrick Guertin, Jiyoung Lee, Michael Fisher
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Publication number: 20180126344Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: ApplicationFiled: April 11, 2016Publication date: May 10, 2018Inventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala
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Patent number: 9891080Abstract: A probe assembly for inserting a probe into a flexible or semi-rigid vessel or tubing having a distal aseptic connector for coupling to the vessel or tubing, the probe sheath comprising at least a portion that is rigid, the probe sheath extending longitudinally from the aseptic connector and having at least one inner longitudinal lumen configured to receive an elongate sensor or probe body and to permit longitudinal movement of the sensor/probe body within the probe sheath lumen, and an actuator for deploying a probe within the vessel or tubing by advancing the probe body through the aseptic connector to a position where the probe can measure at least one parameter within the vessel or tubing is disclosed herein.Type: GrantFiled: October 28, 2012Date of Patent: February 13, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard L. Damren, Colin R. Tuohey, Thomas Erdenberger, Michael Fisher, Jonathan A. Kenney, Parrish M. Galliher, Joseph D. Crowell
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Patent number: 9719705Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, the system comprising: a condenser container capable of holding a fluid, the condenser container comprising: an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; and a first fitment attached to the outer wall surface of the condenser container, the first fitment forming a first port configured to allow the moist gas stream to flow through the first port and into the interior chamber; a second fitment attached to the outer wall surface of the condenser container, the second fitment forming a second port configured to allow a dried gas to flow from the interior chamber and out of the second port; and a cooling device in contact with at least one portion of the outer wall surface of the condenser container and arranged to cool the at least one portion of the outer wall surface of the condenser container, therebyType: GrantFiled: April 18, 2016Date of Patent: August 1, 2017Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Patric Fricking, Parrish Galliher, Geoffrey Hodge, Michael Fisher, Patrick Guertin, Richard Damren, Colin Tuohey, Thomas Erdenberger
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Publication number: 20170051246Abstract: Disclosed is a jacketed, tiered baffle, bioreactor tank comprising an outer cylindrical-shaped jacket and a cylindrical tank having an inner tank surface defining a chamber configured for supporting a flexible bag disposed within the chamber, and an outer tank surface having tiered baffles configured for routing a heat exchange fluid around the entirety of the outer tank surface, the cylindrical tank disposed axially within the outer cylindrical-shaped jacket. The outer cylindrical-shaped jacket is sealed to the cylindrical tank in a manner sufficient to prevent or minimize loss of the heat exchange fluid.Type: ApplicationFiled: November 8, 2016Publication date: February 23, 2017Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: PARRISH M. GALLIHER, THOMAS ERDENBERGER, COLIN R. TUOHEY, JOSEPH D. CROWELL, RICHARD L. DAMREN
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Patent number: RE49606Abstract: A bioprocess mixer (1), which comprises: —a support vessel (2) with at least one side wall (3, 4, 5, 6) and a bottom wall (7), where the walls define a support vessel inner volume (8), and at least a first (9) and a second (10) magnetic impeller drive unit; and —a flexible bag (11, 111) adapted to fit inside the support vessel inner volume, where the bag has at least one bag side wall (12, 112, 13, 113, 14, 15), a bag bottom wall (16, 116) and a bag top wall (17, 117) defining a bag inner volume (18), and at least a first (19) and a second (20) magnetic impeller rotatably attached to a bag wall in the bag inner volume.Type: GrantFiled: May 6, 2021Date of Patent: August 15, 2023Assignee: Global Life Sciences Solutions USA LLCInventors: Patrik Berndt Akerstrom, Richard Lee Damren, Colin R. Tuohey, Thomas Erdenberger, Jonathan Kenney, David Lawrence Brazell, Wei Jin, Roberto Miguel Cabral, Sampath Telikcherla Kandala