Patents by Inventor Thomas Falkman
Thomas Falkman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11981887Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: GrantFiled: February 24, 2023Date of Patent: May 14, 2024Assignee: Cytiva Sweden ABInventors: Andreas Andersson, Lars Johan Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Troeng, Claes Peterson
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Publication number: 20230212497Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: ApplicationFiled: February 24, 2023Publication date: July 6, 2023Inventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Troeng, Claes Peterson
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Patent number: 11613726Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: GrantFiled: July 18, 2017Date of Patent: March 28, 2023Assignee: CYTIVA SWEDEN ABInventors: Andreas Andersson, Lars Johan Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Peterson
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Publication number: 20230031710Abstract: Systems (700) and methods (800) for method of continuous fluid flow in a bioreactor (700) is provided. The method (800) comprises providing (805) a bioreactor system (700) including a bioreactor volume (720), a filtration part (730), and a recirculation line (721) including a recirculation pump (722) is provided between the bioreactor volume (720) and the filtration part (730). The method (800) further comprises providing (810) a plurality of sensors (760) along the recirculation line (721) and monitoring the fluid flow parameters using the sensors (760). The method further comprises sending (820) a plurality of signals from the sensors (760) indicative of the fluid flow parameters to one or more controllers; and controlling (830) the fluid flow rate at the recirculation pump (722) by means of the or each controller.Type: ApplicationFiled: December 17, 2020Publication date: February 2, 2023Inventors: Praveen Paul, Sahebagouda Alagur, Thomas Falkman, Prashanth Hosabettu Mohan
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Publication number: 20220403318Abstract: The present subject matter discloses a bioreactor apparatus. The bioreactor apparatus comprises a bioreactor vessel configured to culture cells. The bioreactor apparatus furthermore comprises a sensor configured to measure Dissolved Oxygen (DO) in the bioreactor vessel. The DO measurements comprise a plurality of DO values recorded at, at least, a plurality of time instances during operation of the bioreactor apparatus. The bioreactor apparatus furthermore comprises a controller configured to obtain the DO measurements. The controller furthermore is to determine, in real-time or approximately real-time, an oxygen mass transfer co-efficient (kLa) associated with the operation of the bioreactor apparatus. Furthermore, the controller is configured to control, in real-time or approximately real-time, at least one cell culture parameter associated with the operation of the bioreactor apparatus based on the kLa.Type: ApplicationFiled: October 1, 2020Publication date: December 22, 2022Inventors: Shivakumar Selvaraj, Bineesh Kandoth, Sahebagouda Alagur, Nagaraj Raghavendra Rao, Thomas Falkman
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Patent number: 11525111Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.Type: GrantFiled: September 27, 2019Date of Patent: December 13, 2022Assignee: Cytiva Sweden ABInventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
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Publication number: 20220372422Abstract: Systems (100) and methods for perfusion control in a bioreactor (120) are provided. The system (100) comprises a media container (110) connected to the bioreactor (120) and weighing scales (113, 123) measure weight of the bioreactor (120) and the media container (110). A plurality of controllers (225, 245) are connected to the weighing scales and configured to continuously feed the media from media container (110) to the bioreactor (120) at a user defined rate using a motor pump (112). A filter (130) is provided to receive feed from the bioreactor (120) through a recirculation line (121) and a permeate flow line (141) is connected to the filter (130) to flow out the permeate from the filter (130).Type: ApplicationFiled: August 5, 2020Publication date: November 24, 2022Inventors: Sudeep Kumar DAM, Praveen PAUL, Prashanth H M, Pradeep KUMAR, Victor JOSE, Sahebagouda ALAGUR, Mandar Chandrakant NARVEKAR, Thomas FALKMAN, Ajay GORE
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Patent number: 11291942Abstract: The invention discloses a condenser for a bioreactor exhaust, comprising: an inlet (1) adapted to be fluidically connected to a bioreactor exhaust port (2), a cooling chamber (3; 103) fluidically connected to the inlet and via a filter device (4) to an outlet (5), a cooling conduit (6; 106) in contact with the cooling chamber, a heating conduit (7) in contact with the filter device and a vortex tube (8) arranged to convey a cold gas stream through the cooling conduit and to convey a hot gas stream through the heating conduit.Type: GrantFiled: August 23, 2016Date of Patent: April 5, 2022Assignee: Cytiva Sweden ABInventors: Eric Faldt, Thomas Falkman, Patric Fricking, Patrick Jonsson, Tomas Agren
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Publication number: 20220023807Abstract: A sparger assembly (700) for a bioprocessing system includes a base plate (710) and at least one aeration manifold (712, 714) removably connected to tire base plate. Each aeration manifold includes at least one inlet for receiving a gas and a plurality of gas outlet openings for delivering tire gas to a fluid within the bioprocessing system. An impeller assembly (740) fora bioprocessing system includes a hub and at least one blade (742) operatively connected to the hub. The at least one blade includes a first portion connected to the hub and extending generally vertically, and a second portion extending at an upward angle from tire first portion.Type: ApplicationFiled: December 4, 2019Publication date: January 27, 2022Inventors: Richard Damren, Timothy Becker, Colin Tuohey, Ralph Stankowski, Sree Ramulu Bandaru, Saravanan Balakrishnan, Thomas Falkman, Pierre Le Greves, Tomas Dalmo, Nagaraj Rao, Mikael Petersson, Manas Dash
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Publication number: 20200087605Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.Type: ApplicationFiled: September 27, 2019Publication date: March 19, 2020Applicant: GE Healthcare Bio-Sciences ABInventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
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Patent number: 10450540Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.Type: GrantFiled: April 27, 2015Date of Patent: October 22, 2019Assignee: GE Healthcare Bio-Sciences ABInventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
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Publication number: 20180243679Abstract: The invention discloses a condenser for a bioreactor exhaust, comprising: an inlet (1) adapted to be fluidically connected to a bioreactor exhaust port (2), a cooling chamber (3; 103) fluidically connected to the inlet and via a filter device (4) to an outlet (5), a cooling conduit (6; 106) in contact with the cooling chamber, a heating conduit (7) in contact with the filter device and a vortex tube (8) arranged to convey a cold gas stream through the cooling conduit and to convey a hot gas stream through the heating conduit.Type: ApplicationFiled: August 23, 2016Publication date: August 30, 2018Inventors: Eric Faldt, Thomas Falkman, Patric Fricking, Patrick Jonsson, Tomas Agren
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Publication number: 20170313967Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: ApplicationFiled: July 18, 2017Publication date: November 2, 2017Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Petterson
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Patent number: 9738863Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: GrantFiled: February 21, 2012Date of Patent: August 22, 2017Assignee: GE Healthcare Bio-Sciences ABInventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Petterson
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Publication number: 20170044477Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.Type: ApplicationFiled: April 27, 2015Publication date: February 16, 2017Inventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
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Patent number: 9550609Abstract: A container comprising a first material and a second material, the first material being a flexible material and the second material being a rigid or semi-rigid material and at least partially defining an interior compartment for keeping a fluid inside the container characterized in that the flexible material and/or the semi-rigid or rigid material have thermoplastic properties and wherein the flexible material and the semi-rigid or rigid material are joined together by a seal or joint which comprises a heat seal and an adhesive seal.Type: GrantFiled: June 20, 2013Date of Patent: January 24, 2017Assignee: GE Healthcare Bio-Sciences ABInventors: Shujian Yi, Rolf Hjorth, David Ronnholm, Thomas Falkman
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Publication number: 20150367992Abstract: A container comprising a first material and a second material, the first material being a flexible material and the second material being a rigid or semi-rigid material and at least partially defining an interior compartment for keeping a fluid inside the container characterized in that the flexible material and/or the semi-rigid or rigid material have thermoplastic properties and wherein the flexible material and the semi-rigid or rigid material are joined together by means of a seal or joint which comprises a heat seal and an adhesive sealType: ApplicationFiled: June 20, 2013Publication date: December 24, 2015Inventors: Shujian YI, Rolf Hjorth, David Ronnholm, Thomas Falkman
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Publication number: 20130316446Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: ApplicationFiled: February 21, 2012Publication date: November 28, 2013Applicant: GE HEALTH CARE BIO-SCIENCES ABInventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Petterson