Abstract: A parcel transfer system transfers a parcel or a similar article directly between a conveyor and a self-driving vehicle (“SDV”) while the conveyor and SDV are moving. The conveyor, SDV, or both may be configured to initially transport a parcel in a first direction of travel and then subsequently offload the parcel in a second direction of travel. The SDV is configured to travel alongside of the conveyor in the first direction of travel and either receive the parcel as it is offloaded from the conveyor or offload the parcel onto the conveyor in the second direction of travel. The parcel transfer system further includes a vision and control subsystem, which regulates movement of the SDV and offloading of the parcel from the conveyor or SDV.

Abstract: The present invention relates to a phosphomimetic RAGE protein comprising an amino acid sequence that is at least 90% identical to a native mammalian RAGE isoform or fragment thereof wherein at least one serine present in the cytoplasmatic tail of the mammalian RAGE isoform is replaced by a phosphomimetic structure. The invention further relates to a polynucleotide encoding phosphomimetic RAGE protein and a vector comprising the polynucleotide. Finally, the invention relates to a composition comprising carrier and an active pharmaceutical ingredient, selected from the RAGE protein the vector for use in the treatment or prevention of a disease in a patient, wherein the disease is preferably selected from a disease initiated by impaired DNA repair, a disease initiated by increased DNA damage or a disease initiated by increased senescence.

Abstract: Described are flame retardant, porous plastic flame arrestors. The flame retardant, porous plastic flame arrestor is formed by irradiating a flame retardant polymer resin to achieve a fractional melt index, grinding the flame retardant polymer resin into a powder, and sintering the flame retardant polymer resin to form a porous structure. Irradiating the flame retardant polymer resin increases the resin's molecular weight and reduces the resin's melt index through crosslinking.

Abstract: A parcel transfer system transfers a parcel or a similar article directly between a conveyor and a self-driving vehicle (“SDV”) while the conveyor and SDV are moving. The conveyor, SDV, or both may be configured to initially transport a parcel in a first direction of travel and then subsequently offload the parcel in a second direction of travel. The SDV is configured to travel alongside of the conveyor in the first direction of travel and either receive the parcel as it is offloaded from the conveyor or offload the parcel onto the conveyor in the second direction of travel. The parcel transfer system further includes a vision and control subsystem, which regulates movement of the SDV and offloading of the parcel from the conveyor or SDV.

Abstract: The present invention relates to a phosphomimetic RAGE protein comprising an amino acid sequence that is at least 90% identical to a native mammalian RAGE isoform or fragment thereof wherein at least one serine present in the cytoplasmatic tail of the mammalian RAGE isoform is replaced by a phosphomimetic structure. The invention further relates to a polynucleotide encoding phosphomimetic RAGE protein and a vector comprising the polynucleotide. Finally, the invention relates to a composition comprising carrier and an active pharmaceutical ingredient, selected from the RAGE protein the vector for use in the treatment or prevention of a disease in a patient, wherein the disease is preferably selected from a disease initiated by impaired DNA repair, a disease initiated by increased DNA damage or a disease initiated by increased senescence.

Abstract: A hook and loop fastener includes a first strip having one of loops or hooks and a second strip having another of the loops or the hooks. The first strip has a first longitudinal track orthogonal to the first strip. The second strip has a second longitudinal track, orthogonal to the first longitudinal track. A slider is provided that has an interface disrupting member extends outwardly. A gripping element is provided for manually moving the slider along the first longitudinal track and the second longitudinal track in a first direction and a second direction. Movement of the slider in the first direction brings the first strip into engagement with the second strip. Movement of the slider in the second direction draws the interface disrupting member through the interface between the first strip and the second strip, thereby separating the first strip and the second strip.

Abstract: A hook and loop fastener includes a first strip having one of loops or hooks and a second strip having another of the loops or the hooks. The first strip has a first longitudinal track orthogonal to the first strip. The second strip has a second longitudinal track, orthogonal to the first longitudinal track. A slider is provided that has an interface disrupting member extends outwardly. A gripping element is provided for manually moving the slider along the first longitudinal track and the second longitudinal track in a first direction and a second direction. Movement of the slider in the first direction brings the first strip into engagement with the second strip. Movement of the slider in the second direction draws the interface disrupting member through the interface between the first strip and the second strip, thereby separating the first strip and the second strip.

Abstract: Described are flame retardant, porous plastic flame arrestors. The flame retardant, porous plastic flame arrestor is formed by irradiating a flame retardant polymer resin to achieve a fractional melt index, grinding the flame retardant polymer resin into a powder, and sintering the flame retardant polymer resin to form a porous structure. Irradiating the flame retardant polymer resin increases the resin's molecular weight and reduces the resin's melt index through crosslinking.

Abstract: The present invention relates to compounds which inhibit or antagonize the binding of methylglyoxal (MG) and/or other reactive carbonyl species (RCS) to an arginine- or lysine- containing protein, preferably an arginine- or lysine-containing cellular protein, such as a sodium ion channel, e.g. the sodium ion channel Na(v)1.8. Preferred scavenger compounds are peptides comprising several or multiple repeats of the amino acid sequence motif Gly-Glu-X-Pro (GEXP), wherein X is Arg or Lys, and pharmaceutical compositions thereof. The present invention furthermore relates to the use of the compounds as scavenger or antagonists of methylglyoxal and/or related reactive carbonyl species (RCS). The present invention furthermore relates to the use of the compounds for the prevention and/or treatment of pain, hyperalgesia and pain related diseases, in particular pain and/or hyperalgesia caused by or associated with methylglyoxal and/or reactive carbonyl species (RCS).

Abstract: The present invention relates to compounds which inhibit or antagonize the binding of methylglyoxal (MG) and/or other reactive carbonyl species (RCS) to an arginine- or lysine- containing protein, preferably an arginine- or lysine-containing cellular protein, such as a sodium ion channel, e.g. the sodium ion channel Na(v)1.8. Preferred scavenger compounds are peptides comprising several or multiple repeats of the amino acid sequence motif Gly-Glu-X-Pro (GEXP), wherein X is Arg or Lys, and pharmaceutical compositions thereof. The present invention furthermore relates to the use of the compounds as scavenger or antagonists of methylglyoxal and/or related reactive carbonyl species (RCS). The present invention furthermore relates to the use of the compounds for the prevention and/or treatment of pain, hyperalgesia and pain related diseases, in particular pain and/or hyperalgesia caused by or associated with methylglyoxal and/or reactive carbonyl species (RCS).

Abstract: The present invention relates to a hand held cable reel (1) comprising a central cable receiving core (3) mounted between a pair of disc like end flanges (5, 7), each disc like end flange (5, 7) having a handle (9, 11) mounted on the outermost surface of the flange, the handles being radially offset from the central axis of the cable receiving core (3) and circumferentially offset relative to each other. The handles (9, 11) are substantially c-shaped having a body portion (13) and a pair of inwardly depending arms (15, 17), the free end of each of the arms facing inwardly towards the flange (5, 7) upon which it is mounted. A pair of operating flanges (161, 163) freely rotatable with respect to the end flanges may also be provided.

Abstract: The present invention relates generally to vitamin B12 nasal spray compositions and methods of using the same in the treatment of vitamin B12 deficiency and various disorders that are related to such deficiency. In particular embodiments, the present invention is directed to treatment methods comprising intranasal administration of a cobalamin composition according to a particular dosing and frequency schedule and to a preservative-free nasal spray composition comprising a cobalamin compound useful in the practice of such treatment methods.

Abstract: Methods for moving a media sheet through the media path of an image forming device. In one embodiment, the media sheet may be moved by a pick mechanism having a pick roll from an input tray. The pick roll in the input tray may maintain contact with the media sheet and drive the sheet at a first elevated speed as it moves towards the nip. The pick roll may then slow as it brings the leading edge into contact with the nip. This slower speed may reduce the amount of nip shock or compression that may cause reengagement of the pick mechanism and an unintentional double sheet feed. Moving the media sheet at the fast speed a majority of the distance along the media path between the input tray and nip may increase media throughput.

Abstract: An earplug with a stem (22) and with fins (31-34) extending at rearward and radially-outward inclines from the stem, is constructed for comfort and for high noise blocking. The stem has a multiplicity of air pockets (60) lying in an imaginary band (62) that lies on the earplug axis (20). The band has opposite band sides (64, 66) spaced radially inward of the periphery (40) of the stem, the air pockets helping to block the passage of noise. A plurality of the fins are of constant thickness with parallel front and rear surfaces (50, 52), and with the fins being stubby with a fin thickness (T) at least 20% of the fin length (E), and with the front surface (50) of each fin being at least 20% longer than the fin length (E), all as seen in a sectional view taken along the earplug axis (20). Stem peripheral parts (80) that lie between adjacent fins, extend continuously at rearward and radially inward inclines of more than 15°.

Abstract: A fastening tool to releasably engage a peripheral or internal wall of a concrete block defining an internal channel for lifting and placement provides a “U” shaped body with spaced depending legs to fit over the wall of the block. The body supports an “L” shaped external tong arm bracket pivotally carrying a similarly “L” shaped tong arm, with an engaging hook at a depending end and attachment means for a lifting line carried by a lifting mechanism at an opposed horizontal end, to frictionally engage the block wall between the body legs when the tool is lifted by the tong arm attachment means. The body back carries an upstanding “U” shaped handle for manually lifting the body for tool placement and release. A system provides plural fastening tools carried in lateral adjacency on a supporting beam attachable to a lifting mechanism.

Abstract: A cab enclosure for a self-propelled earth moving machine which includes a plurality of flexible planar fabric panels namely, a front panel, a rear panel, a right side panel and a left side panel. Each of the panels having a top edge, a bottom edge, opposed side edges, and at least one transparent viewing window. Mating fasteners are positioned along the opposed edges of each of the panels, whereby adjoining panels are secured together to form an enclosure. The top edge of each of the panels being secured to a canopy of an open metallic cab structure of the self-propelled earth moving machine, whereby the panels hang like drapes to enclose the cab.

Abstract: A water ski has an upper side, an under side, a front end and a rear end, with an arched fin carried on the ski under side at the ski rear end. The arched fin has opposed edges adjacent the edges of the ski under side, with the opposed edges joined together adjacent the ski rear end to form an opening for water flow therethrough, and with the opposed edges tapering forward and upward from the opening to the ski under side, and terminating forward of the ski rear end. The arched fin and ski form a continuous channel for water flow along the bottom of the ski toward the rear end, preferably with the cross-section area of the forward end of the channel is greater than the cross-section area of the rear end of the channel.

Abstract: An attachment (10) for safety eyeglasses includes a mount (30) that mounts on an eyeglass temple bar, an earplug (32) that can fit into the ear canal to block noise, and a coupling (34) that connects the mount to the earplug. The mount includes a tube of elastomeric material that can be stretched over the temple bar to fix its position and prevent "jiggling". The coupling includes a wire of resilient plastic that is wound into a tight helix. The diameter of the helix is about 1 cm, which allows it to be stored between the rear of the outer ear and the skull, to minimize earplug motion when the earplug is not inserted into the ear canal.

Abstract: A cell strainer assembly useful for filtering and collecting suspensions for use in immunological studies and more particularly in flow cytometry procedures. The assembly comprises a container and a cap with means for filtering and collecting a suspension.

Abstract: A cell strainer assembly useful for filtering and collecting suspensions for use in immunological studies and more particularly in flow cytometry procedures. The assembly comprises a container and a cap with means for filtering and collecting a suspension.