Patents by Inventor Thomas G. Hullinger

Thomas G. Hullinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Locked nucleic acid inhibitor of miR-145 and uses thereof
    Patent number: 9752143
    Abstract: The present invention provides oligonucleotides with chemical motifs that are miR-145 inhibitors. The oligonucleotides can be used for the treatment and prevention of a condition by inhibiting the expression or activity of miR-145 in cells of a subject in need thereof. Methods provided include treating or preventing pulmonary arterial hypertension, neointima formation, restenosis or hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors are also disclosed.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 5, 2017
    Assignee: MIRAGEN THERAPEUTICS, INC.
    Inventors: Anita G. Seto, Eva van Rooij, Kathryn H. Hutnick, Christina M. Dalby, Thomas G. Hullinger, Rusty Montgomery
  • LOCKED NUCLEIC ACID INHIBITOR MIR-145 AND USES THEREOF
    Publication number: 20160010091
    Abstract: The present invention provides oligonucleotides with chemical motifs that are miR-145 inhibitors. The oligonucleotides can be used for the treatment and prevention of a condition by inhibiting the expression or activity of miR-145 in cells of a subject in need thereof. Methods provided include treating or preventing pulmonary arterial hypertension, neointima formation, restenosis or hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors are also disclosed.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 14, 2016
    Inventors: Anita G. Seto, Eva van Rooij, Kathryn H. Robinson, Christina M. Dalby, Thomas G. Hullinger, Rusty Montgomery