Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: In one aspect, compounds and associated pharmaceutical compositions are described herein comprising isolated cannabicitran (CBT-C (3)). In some embodiments, CBT-C (3) enantiomers are isolated and/or prepared. In some further embodiments, the biological activity of enantiomers are determined. In some further embodiments, one or more enantiomers may be incorporated into a composition.

Abstract: Vaporization devices, systems, and methods with automated thermal profile control are disclosed. Thermal profile information for a particular vaporizable material is encoded to control the operation of the vaporizer. The thermal profile is defined by a plurality of set points specified by power/temperature setting for a specified time. The thermal profile may be configured to be applied during a single or multiple inhalations. A thermal profile recipe code containing thermal profile information associated with the vaporizer cartridge and/or vaporizable material contained therein may be used to control the thermal profile. The thermal profile information may be automatically read by or communicated to the vaporizer and used thereby to automatically control the vaporizer heating element to implement the desired thermal profile associated with the vaporization material.

Abstract: An infusion system having an integrated inserter and infusion set (10) for containing and placing a flexible catheter (40), and a retractable introducer needle (26), wherein the catheter (40) is isolated from movement after placement. The integrated inserter and infusion set (10) includes a hub (20), having a user push button (30) to activate the device for catheter (40) placement. An adhesive liner (34) can be provided to cover an adhesive layer (36), such as pressure sensitive adhesive (PSA), on the bottom of the device (10).

Abstract: A database stores a document as a plurality of encrypted records, where each record is indicative of an incremental change to the state of the document, and encrypted using a document key. The document key is stored with encryption decryptable using a group key, and the group key is stored with encryption decryptable using a first access key. In response to a request to rotate from the first access key to a second access key, the database decrypts the group key using the first access key, a stores a group key re-encrypted with the second access key.

Abstract: FIGS. 1-16D & 66A-92D disclose a large variety of methods of forming the headgear for use in combination with a breathing apparatus including a unitary plastic core within textile casings. In some configurations, the plastic core material penetrates or bursts-through the textile casing of the straps. Some configurations include over moulding, alignment posts, T-joints and joint housings with injection aperture. FIGS. 17-65 & 93A-94C disclose a large variety of different headgear arrangements including top strap, front strap, rear strap and pairs of straps extending from the mask above and below the ear to meet behind the ear. FIGS. 95-121B disclose a large variety of connectors connecting the headgear assembly to the mask assembly where the headgear, mask and connector form a closed loop when the connector is disengaged with the mask assembly.

Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.

Abstract: An electrified vehicle includes a storage compartment positioned forward of a vehicle passenger cabin and accessible by opening a vehicle hood, a thermally conductive plate or heat exchanger in contact with a bottom surface of the storage compartment and having an associated conduit configured for circulating a working fluid from a vehicle cooling system, and a valve operable to control flow of the working fluid through the conduit. The storage compartment may be filled with a cooling medium, such as ice or dry ice, to provide enhanced cooling during high-demand operation or charging of the vehicle, such as when operating in a performance/track mode, towing a trailer, or in other extreme use scenarios. The valve may be controlled so that the working fluid bypasses the conduit when the storage compartment is used for cargo and/or enhanced cooling is not desired.

Abstract: An example method includes generating a signal correlated with blood perfusion or SpO2 of a subject at a location and orientation on a body of the subject; determining a signal quality and/or signal strength of the signal; and in dependence on the signal quality and/or signal strength, either indicating that at least one of the location or the orientation is acceptable for placement of a biosensor on the body of the subject or prompting the subject or other person to reposition the biosensor. The biosensor may be part of a chest sensor device that includes: an adhesive with a liner having pull tabs for easy removal when the chest sensor device is positioned at a desired location; a finger grip to facilitate removal of the chest sensor device from the subject after a period of use; and/or wraparound fingers to secure the chest sensor device to the adhesive.

Abstract: A validation system for executing a method for prioritizing validation tasks, wherein the validation tasks are carried out by execution units of the validation system, wherein the execution units are divided into at least two groups and each group is assigned capabilities by the validation system and/or by a user of the validation system, so that execution units of a respective group have the capabilities of the group and, when the validation tasks are executed automatically by the validation system and/or by the user, a requirement of the respective validation task for the capability of the execution units and a priority for execution are specified and, taking into account the priorities and the capable execution units, an execution sequence is determined and the validation task is executed according to the execution sequence by the capable execution units.

Abstract: Described herein are apparatuses (such as desks) with adjustable top panels. In some embodiments, an apparatus includes a frame, having a movable component that is configured to move upwards and downwards. The apparatus also includes: a first top panel attached to the movable component and configured to move upwards and downwards with the movable component, and a second top panel attached to the frame and aligned parallel to the first panel, so that the first panel is adjustable to be flush with the second panel or adjustable to a level above the second panel. The apparatus can also include a barrier panel attached to the frame or the first panel, arranged perpendicular to the first and second panels and oriented downward from the first panel at a side of the first panel closest to the second panel.

Abstract: The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.

Abstract: Described herein are apparatuses (such as desks) with adjustable top panels. In some embodiments, an apparatus includes a frame, having a movable component that is configured to move upwards and downwards. The apparatus also includes: a first top panel attached to the movable component and configured to move upwards and downwards with the movable component, and a second top panel attached to the frame and aligned parallel to the first panel, so that the first panel is adjustable to be flush with the second panel or adjustable to a level above the second panel. The apparatus can also include a barrier panel attached to the frame or the first panel, arranged perpendicular to the first and second panels and oriented downward from the first panel at a side of the first panel closest to the second panel.

Abstract: Described herein are apparatuses (such as desks) with adjustable top panels. In some embodiments, an apparatus includes a frame, having a movable component that is configured to move upwards and downwards. The apparatus also includes: a first top panel attached to the movable component and configured to move upwards and downwards with the movable component, and a second top panel attached to the frame and aligned parallel to the first panel, so that the first panel is adjustable to be flush with the second panel or adjustable to a level above the second panel. The apparatus can also include a barrier panel attached to the frame or the first panel, arranged perpendicular to the first and second panels and oriented downward from the first panel at a side of the first panel closest to the second panel.

Abstract: An artificial intelligence (AI) system may be configured to efficiently annotate most if not all unlabeled image data. Some embodiments may: provide, to an object-detection, machine-learning (ML) model, a plurality of unlabeled data such that the object-detection model predicts a plurality of regions; correct at least one vertex of bounds of at least one of the regions such that the bounds fit tighter around an object; convert the regions to first subregions by cropping the first subregions from the unlabeled data; and provide the first subregions to an embedding, ML model configured to output feature vectors for each of the first subregions.

Abstract: An apparatus and method for determining sheet material edges on a surface including a sensor configured to detect an outer edge and a usable edge of the sheet material and a controller in communication with the sensor. The sensor comprises a first color optical sensor producing a first signal representing a first physical attribute of the sheet material and a second color optical sensor producing a second signal representing a second physical attribute of the sheet material. The controller comprises a processor, a memory, and a communications adapter, controls dispensing and spreading of the sheet material for detection by the sensor, and signals to a user a presence of the usable edge in the sheet material upon detection by the sensor.

Abstract: There is provided a method that includes (a) receiving an activation signal from a user interface, (b) receiving data indicative of an occurrence of an event, (c) allotting a benefit, in response to the occurrence of the event, (d) recognizing that the event occurred within a window of time with respect to a time of occurrence of the activation signal, and (e) modifying the benefit to yield a modified benefit. There is also provided a system that performs the method.

Abstract: A lighting controller comprises power circuitry, transmitter circuitry, a touch-sensitive panel, and processing circuitry. The power circuitry is configured to relay power from the lighting controller to a solid state lighting fixture wired to the lighting controller. The transmitter circuitry is configured to wirelessly exchange signals with the solid state lighting fixture. The touch-sensitive panel is configured to emit light and receive touch input from a user. The processing circuitry is electrically coupled to the power circuitry, the transmitter circuitry, and the touch-sensitive panel. The processing circuitry is configured to wirelessly control, via the transmitter circuitry, the attribute of light emitted by the solid state lighting fixture in accordance with the touch input received via the touch-sensitive panel and control the light emitted from the touch-sensitive panel to indicate the attribute as the attribute is wirelessly controlled.

Abstract: A system for processing a work-piece including a sheet of material into pieces includes a production environment configured for collecting data characterizing the work-piece and for subsequently cutting the work-piece into a plurality of products; and a development environment separate from the production environment, the development environment configured for receiving characterization data from the production environment, developing a nesting strategy for cutting the work-piece and providing the nesting strategy.

Abstract: An apparatus and method for determining sheet material edges on a surface including a sensor configured to detect an outer edge and a usable edge of the sheet material and a controller in communication with the sensor. The sensor comprises a first color optical sensor producing a first signal representing a first physical attribute of the sheet material and a second color optical sensor producing a second signal representing a second physical attribute of the sheet material. The controller comprises a processor, a memory, and a communications adapter, controls dispensing and spreading of the sheet material for detection by the sensor, and signals to a user a presence of the usable edge in the sheet material upon detection by the sensor.