Patents by Inventor Thomas H. Maren

Thomas H. Maren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3,4-thiadiazoline-5-sulfonamides
    Patent number: 4746745
    Abstract: Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase inhibitor comprising a sulfonamide having the following properties:a. sufficiently soluble in water to form at least a 3 mM solution at pH 8.2 or a pKa of not greater than 7.3;b. ether partition coefficient of at least 1.0;c. chloroform partition coefficient of at least 0.01;d. dissociation constant against carbonic anhydrase of not more than 3.times.10.sup.-8 molar;e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr.sup.-1 ;f. not injurious to the cornea; andg. stable in aqueous solution and in contact with the cornea.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: May 24, 1988
    Inventor: Thomas H. Maren
  • Process for reducing intraocular pressure
    Patent number: 4619939
    Abstract: Process and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a caronic anhydrase inhibitor comprising a sulfonamide having the following properties:a. sufficiently soluble in water to form at least a 3 mM solution at pH 8.2 or a pKa of not greater than 7.3;b. ether partition coefficient of at least 1.0;c. chloroform partition coefficient of at least 0.01;d. dissociation constant against carbonic anhydrase of not more than 3.times.10.sup.-8 molar;e. first order rate constant for penetration of the sulfonamide through a living rabbit cornea of at least 0.005 hr.sup.-1 ;f. not injurious to the cornea; andg. stable in aqueous solution and in contact with the cornea.
    Type: Grant
    Filed: May 3, 1985
    Date of Patent: October 28, 1986
    Assignee: University of Florida
    Inventor: Thomas H. Maren