Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.

Abstract: A composite circular connector seal, or an assembly comprising a plurality of such seals, may be engineered to seal across a predetermined tolerance band for such seals by using two substantially circular seal elements sized to slidingly fit about a tubular that has a positive and negative outer diameter tolerance range, where each seal element is terminated at one circumferential edge with a packer cap, and a core element disposed intermediate the two substantially circular seal elements at their respective non-packer cap terminated circumferential edges. The two substantially circular seal elements comprise an organic thermoplastic polymer and the core seal element, which typically comprises a synthetic rubber, is also typically molded to the two seal elements at their respective non-packer cap terminated circumferential edges.

Abstract: A composite circular connector seal, or an assembly comprising a plurality of such seals, may be engineered to seal across a predetermined tolerance band for such seals by using two substantially circular seal elements sized to slidingly fit about a tubular that has a positive and negative outer diameter tolerance range, where each seal element is terminated at one circumferential edge with a packer cap, and a core element disposed intermediate the two substantially circular seal elements at their respective non-packer cap terminated circumferential edges. The two substantially circular seal elements comprise an organic thermoplastic polymer and the core seal element, which typically comprises a synthetic rubber, is also typically molded to the two seal elements at their respective non-packer cap terminated circumferential edges.