Abstract: A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S.

Abstract: In an embodiment, a student may be provided with instructions via computer in an area in which illustrating the physical positioning of the human body or other object may be beneficial. In an embodiment a system of one or more instruction stations may be provided where the student may record practice sessions and/or view prerecorded lessons without the presence of the instructor. In an embodiment, at a later date the instructor may view the recorded practice sessions, and prepare a video that may include a critique of the recorded practice session and/or a new lesson. In an embodiment, a student may initiate the video or lesson review process at any time from any number of devices having access to one or more networks having the source video file saved on any number of devices accessible by the network.

Abstract: A method of diagnosing the presence of, or susceptibility to, retinal dystrophy, cardiomyopathy endocrinopathy, diabetes or Alstrom disease in an individual, which method comprises typing in a sample from the individual the ALMS1 protein or ALMS1 gene region of the individual, or detecting aberrant ALMS1 activity, and thereby determining whether the individual has, or is susceptible to, retinal dystrophy, cardiomyopathy, endocrinopathy, diabetes or Alstrom disease. Use of an agent that modulates (i) the ALMS1 protein, or (ii) a component that affects or is affected by ALMS1, in the manufacture of a medicament for prevention or treating retinal dystrophy, cardiomyopathy, endocrinopathy, diabetes or Alstrom disease.