Abstract: Active compounds of Formulas I - IX are provided herein that are useful as TREX1 inhibitors, which in turn is useful for stimulating the cGAS-STING pathway. As such, these compounds may be used in a method of treating disease or disorder in which modulation of TREX1 would be of benefit, such as a cancer, viral infection, or autoimmune disease.

Abstract: A valve includes a body having an interior and defining at least one inlet passageway and discharge passageway. The valve also includes a flow diverter disposed within the body between the inlet and discharge passageways to receive a fluid from the inlet passageway in an inlet direction. The diverter is adapted to discharge the fluid to at least one discharge passageway in a direction that differs from the inlet direction. The diverter is rotatable to vary the discharge direction. According to one embodiment, the discharge direction is substantially perpendicular to the inlet direction.

Abstract: A vehicle thermal management system includes an exhaust gas cooler configured to receive exhaust gas from the engine and to cool the exhaust gas before it is recirculated back into the engine. A valve is located downstream from the exhaust gas cooler, and is operable to control the amount of exhaust gas passing through the exhaust gas cooler. Intake air mixes with the exhaust gas downstream from the first valve. The mixed gas is then cooled by a mixed gas cooler before it enters the engine intake manifold. A coolant is circulated through the mixed gas cooler and a heat exchanger. The mixed gas rejects heat to the coolant via the mixed gas cooler, and the coolant rejects heat to the ambient air via the heat exchanger.

Abstract: A vehicle thermal management system includes a temperature control fluid for controlling the temperature of at least a portion of a vehicle system. A pump is configured to pump the temperature control fluid through a heat exchanger to facilitate the transfer of heat between the temperature control fluid and ambient air. A fan is operable to move the ambient air across the heat exchanger to facilitate increased heat transfer. A control system is used to control operation of the pump and the fan. The control system is provided with operation data that includes optimized operating speeds for the pump and the fan to minimize power consumption, while maximizing heat transfer.

Abstract: A water pump assembly for controlling the flow of temperature control fluid in an internal combustion engine. The water pump assembly includes a housing with an inlet, an outlet and an electric motor assembly for causing fluid to flow from the inlet to the outlet. A housing includes a mounting flange for mounting the water pump to an engine. The mounting of the water pump permitting direct flow into or out of the engine from the water pump.

Abstract: In inserted blade rotary end mills having tapered blades inserted in axially extending tapered sockets. The improvement of providing longitudinal interfitting serrations on opposed surfaces of both the inserted blades and sockets to prevent twisting of the blades in the sockets.