Abstract: The present invention relates to an amyloid ? peptide analogues comprising an amino acid sequence or a peptidomimetic thereof, wherein the sequence (i) forms a loop, (ii) has at least 66% identity to the amino acid sequence of native A? peptide or a portion thereof, (iii) comprises at least 6 contiguous amino acid residues and (iv) has at least 2 non-contiguous amino acid residues which are covalently linked with each other, oligomers comprising a plurality of said amyloid ? peptide analogues, processes for preparing the amyloid ? peptide analogues or oligomers, compositions comprising the amyloid ? peptide analogues or oligomers, and uses of the amyloid ? peptide analogues or oligomers such as their use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the amyloid ? peptide analogues or oligomers.

Abstract: The disclosure provides methods of detecting autoantibodies present in the serum of subjects suffering from rheumatoid arthritis. The methods use capture probes and detection probes that can bind to the antifilaggrin autoantibodies or other epitope related autoantibodies. The presence, absence, and/or amount of the autoantibody complex may be detected, wherein the presence of the complex may indicate a positive diagnosis of rheumatoid arthritis.

Abstract: A system and method facilitate searching for an article kept within a storage enclosure. The system includes tag detectors, item tags, and appearance data. Selection of an article for searching by a user enables retrieval of appearance data corresponding to the selected article so that the user may be aware of the packaging of the article for the search. If the user requires more detailed information, the tag detectors may be activated to interrogate for an item identifier embodied in an item tag. The magnitude of the response signals are used to determine the location of the selected article so that it may be displayed with the appearance data.