Abstract: Disclosed is a coater assembly 1 for a 3D printer, comprising a coater 3 having a container 5 which defines an inner cavity for receiving particulate construction material which opens into a container opening 7 for outputting the particulate construction material from the container 5, and an output region 9 which defines a coater output opening 11 for outputting the particulate construction material from the coater 3 onto a construction field. The container 5 is movable relative to the coater output opening 11 so that by moving the container 5 relative to the coater output opening a discharge of particulate construction material from the inner cavity through the container opening 7 and the coater output opening 11 onto the construction field is variable.

Abstract: The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine IL-17 A. The disclosure more specifically relates to specific antibodies and proteins that are IL-17 A antagonists (inhibit the activities of IL-17 A and IL-17 AF) and are capable of inhibiting IL-17 A induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo. The disclosure further relates to compositions and methods of use for said antibodies and proteins to treat pathological disorders that can be treated by inhibiting IL-17A or IL 17AF mediated activity, such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus (SLE), lupus nephritis, chronic obstructive pulmonary disease, asthma or cystic fibrosis or other autoimmune and inflammatory disorders.

Abstract: The invention relates to a transmission (100) for a hybrid drive arrangement which can be coupled to two drive assemblies (7, 8), comprising an input shaft (10), and an output shaft (11), at least one first, second and third shifting element (SE1, SE2, SE3), and at least one double planetary gear (5), comprising a first sun gear and a first ring gear and a second sun gear and a second ring gear and a planet carrier. The input shaft (10) can be coupled to the planet carrier of double planetary gear (5) by means of the first shifting element (SE1) and can be coupled to the first sun gear of the double planetary gear (5) by means of the second shifting element (SE2), and can be coupled to the first ring gear of the double planetary gear (5) by means of the third shifting element (SE3) and the output shaft (11) is coupled to the planet carrier of the double planetary gear (5).

Abstract: The invention relates to a transmission (100) for a hybrid drive arrangement which can be coupled to two drive assemblies (7, 8), comprising an input shaft (10), and an output shaft (11), at least one first, second, third, fourth, fifth and sixth shifting element (SE1, SE2, SE3, SE4, SE5, SE6), and at least one planetary gear (5).

Abstract: The invention relates to a method for operating a drive device (1) of a motor vehicle, having an internal combustion engine (2), an electric machine (3), and a dual-clutch transmission (4). The dual-clutch transmission (4) has two clutches (K1, K2), by means of which the transmission can be connected to the internal combustion engine (2). At least the internal combustion engine (2) is actuated in a driving operation in order to generate a target drive torque, and the clutches (K1, K2) are actuated in opposite directions for a gear shift. During a gear shift, the electric machine (3) which is connected to the dual-clutch transmission (4) without a clutch is actuated such that the electric machine completely or partly generates the target torque at least temporarily.

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: In a thrust washer for the axial securing of rolling elements of a bearing, and a gear mechanism including a thrust washer, the thrust washer is arranged as a circular disk, which has an axially protruding, in particular radially outer, projection. The circular disk has a recess, which is disposed out of center, i.e., the center point of the, e.g., circular recess thus particularly being set apart from the center axis and/or from the center point of the circular disk. The projection may have an annular shape, and the ring axis is set apart from the center point of the, e.g., circular recess.

Abstract: A gas turbine membrane seal is disclosed. The gas turbine membrane seal includes a membrane, the membrane configured and arranged to extend from a first gas turbine component to a second gas turbine component and to separate two volumes, and an anti-fretting part configured and arranged to be attached to the first gas turbine component. A face of the anti-fretting part is adjacent to the membrane, and the face of the anti-fretting part is convex. Further embodiments of the gas turbine membrane seal are also described, along with a gas turbine having the gas turbine membrane seal and a retrofitting method.

Abstract: Fan Out Package-On-Package (PoP) assemblies in which a second chip is adhered to a non-active side of a first chip. An active side of the first chip embedded in a first package material may be electrically coupled through one or more redistribution layers that fan out to package interconnects on a first side of the POP. A second chip may be adhered, with a second package material, to the non-active side of the first chip. An active side of the second chip may be electrically coupled to the package interconnects through a via structure extending through the first package material. Second interconnects between the second chip, or a package thereof, may contact the via structure. Use of the second package material as an adhesive may improve positional stability of the second chip to facilitate wafer-level assembly techniques.

Abstract: Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.

Abstract: Drive mechanism (1) for a motor vehicle (6), comprising a dual clutch transmission (10) that includes a first powertrain (13), which can be connected to a first drive unit (2) via a first clutch (21), and a second powertrain (14), which can be connected to the first drive unit (2) via a second clutch (22), the first powertrain (13) being securely coupled to a second drive unit (3); when shifting gears in the dual clutch trans-mission (10), the second drive unit (3) supplies a predefined drive torque.

Abstract: A cargo deck of an aircraft, including a series of at least two floor modules arranged side by side and made of a fiber-composite material. The floor modules each comprise at least one core in the form of a foam core and/or structural core which is interposed between a first cover layer made of fiber-reinforced plastic and a second cover layer made of fiber-reinforced plastic, wherein the floor modules each comprise a coreless peripheral edge region for producing an, in particular laminar, materially bonded connection between the cover layers. The floor modules are arranged in such a way that sections of the coreless edge regions of the floor modules arranged side by side overlap one another, wherein at least one sealing strip, in particular made of silicone foam, is provided between the mutually overlapping edge regions.

Abstract: A side guide for guiding and/or holding cargo items, in particular containers and/or pallets, in an aircraft, comprising a fastening rail extending in the longitudinal direction (v), at least one side guide device, which can be fastened to the fastening rail in the longitudinal direction (v) at different positions (A, B, C, D) and at least one first and at least one second fastening device for fastening the side guide to a cargo deck of the aircraft, in particular in a perforated rail. The first fastening device engages around the fastening rail and/or engages in the fastening rail in such a way that the first fastening device can be displaced in the longitudinal direction (v), in particular relative to the second fastening device.

Abstract: In various example embodiments, a system and method for offering and billing advertisement opportunities are provided. In example embodiments, an advertisement opportunity in media to be communicated to a user device associated with a viewer is identified. Attributes of the advertisement opportunity are determined. Based on these attributes, a value to assign to the advertisement opportunity is determined. The advertisement opportunity is offered to a potential advertiser based on the assigned value determined using the attributes of the advertisement opportunity.

Abstract: In example embodiments, a system and method for providing interactive advertisement is provided. In some embodiments, a component causes a video program having an interactive advertisement to be displayed to a user on a display screen. The interactive advertisement includes an enhanced content activator. In response to activation of the enhanced content activator by the user, enhanced advertisement information including at least one trigger is provisioned. The enhanced advertisement information is then caused to be displayed with the video program and the interactive advertisement. A selection by the user of the at least one trigger associated with the enhanced advertisement information is monitored. In response to selection of the at least one trigger, access to further content associated with the enhanced content information is provided.

Abstract: A mass flow controller (10) comprises a fluid inlet (15) and at least one first flow meter (11) to measure a first flow rate (F1) and to output a first flow signal (FS1); at least one second flow meter (12) to measure a second flow (F2) rate and to output a second flow signal (FS2); a control device (13) connected to said first and second flow meters (11,12) and configured and arranged to generate a control signal (C); and at least one control valve (14) connected to said control device (13) to control a total flow rate (Fout) through the mass flow controller (10) in response to the control signal (C). The control signal (C) is generated as a function of both the first and second flow signals (FS1,FS2) such that the mass flow controller's (10) sensitivity to perturbations of said inlet pressure is minimized.

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: The invention relates to a method for operating a drive device (1) of a motor vehicle, having an internal combustion engine (2), an electric machine (3), and a dual-clutch transmission (4). The dual-clutch transmission (4) has two clutches (K1, K2), by means of which the transmission can be connected to the internal combustion engine (2). At least the internal combustion engine (2) is actuated in a driving operation in order to generate a target drive torque, and the clutches (K1, K2) are actuated in opposite directions for a gear shift. During a gear shift, the electric machine (3) which is connected to the dual-clutch transmission (4) without a clutch is actuated such that the electric machine completely or partly generates the target torque at least temporarily.