Patents by Inventor Thomas I. Doran

Thomas I. Doran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vitamin D3 analogs for the treatment of psoriasis and sebaceous gland diseases
    Patent number: 5747478
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or acyl; provided that only one of R.sup.1 or R.sup.2 is hydrogen are taught as useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: May 5, 1998
    Assignee: Hoffman-La Roche Inc.
    Inventors: Thomas I. Doran, John Arthur McLane
  • Vitamin D3 fluorinated analogs
    Patent number: 5428029
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, X is H.sub.2 or .dbd.CH.sub.2, and the 23,24-double bond is E or Z, are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of tumors such as breast cancer, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne and seborrheic dermatitis.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas I. Doran, Bernard M. Hennessy, John A. McLane, Giacomo Pizzolato, Farhad Sedarati, Milan R. Uskokovic
  • Steroid intermediates for the formation of vitamin D.sub.3 analogues
    Patent number: 5393900
    Abstract: The invention comprises compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or acyl; provided that only one of R.sup.1 or R.sup.2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases. The invention also includes a process for making these compounds and steroid intermediates of the process.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: February 28, 1995
    Assignee: Hoffmann-La Roche inc.
    Inventors: Thomas I. Doran, John A. McLane, Masami Okabe, Michelangelo Scalone, Milan R. Uskokovic
  • 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
    Patent number: 5384314
    Abstract: This invention is for 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol, which can be further characterized by the formula: ##STR1## and which is useful as an agent for the treatment of sebaceous gland diseases such as acne and sebhorreic dermatitis.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: January 24, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas I. Doran, Shian-Jan Shiuey, Milan R. Uskokovic
  • Nonatetraenoic acid derivative for use in treating acne
    Patent number: 5369126
    Abstract: A compound of the formula ##STR1## its pharmaceutically acceptable salts, and its pharmaceutically acceptable hydrolyzable esters for reducing sebum secretion and combatting acne as well as oral and topical compositions for use thereof.
    Type: Grant
    Filed: January 6, 1993
    Date of Patent: November 29, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas I. Doran, Michael Rosenberger, Stanley S. Shapiro
  • Vitamin D3 analogs
    Patent number: 5342833
    Abstract: The invention is drawn to compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or acyl; provided that only one of R.sup.1 or R.sup.2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: August 30, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Thomas I. Doran, John A. McLane, Masami Okabe, Michelangelo Scalone, Milan R. Uskokovic