Abstract: Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.

Abstract: Example fiducial markers include features that make them particularly useful in dental scanning methods for analyzing jaws of a patient, wherein the dental scanning methods involve taking multiple scans of the jaws, and/or models thereof, and then shifting the image of one scan to match that of another. Prior to scanning, the fiducial markers are attached to the patient's jaws to accurately identify and track the relative position of the jaws.

Abstract: A method of bonding includes applying a glass composition to at least a first material surface. The glass composition includes a glass powder and a solvent. The first material surface is disposed onto a second material surface. An elevated temperature is applied to the first material surface and the second material surface to form a bond between the first material surface and the second material surface. The first material surface and the second material surface are compressed under an isostatic pressure.

Abstract: The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles comprising structural units of a polymerizable amino acid and structural units of an acid monomer or a salt thereof. The composition of the present invention is useful in improving lipstick stain resistance in coatings compositions.

Abstract: The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles comprising structural units of a polymerizable amino acid and structural units of an acid monomer or a salt thereof. The composition of the present invention is useful in improving lipstick stain resistance in coatings compositions.

Abstract: The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications.

Abstract: The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications.

Abstract: The invention pertains to N-type calcium channel isoforms containing exon 37a (Cav2.2e[37a]), which are specifically expressed in nociceptive neurons, and nucleic acids relating thereto. Also included are methods for identifying antagonists of Cav2.2e[37a] subunit activity that act by inhibiting the expression or function of the subunit. The invention further relates to methods of using such nucleic acids, polypeptides, and inhibitor molecules in the treatment and/or diagnosis of disease, such as in methods for treating pain, particularly neuropathic pain.

Abstract: A strain-relief end bell for an electrical connector assembly includes a ratcheting mechanism that allows the end bell to resist vibration-induced decoupling once it is threaded onto an electrical connector. The ratcheting mechanism includes a retainer ring that is seated between an internally-threaded coupling ring and an annular fitting around which the coupling ring is rotatably mounted. The retainer ring is fixed to the coupling ring so that both rings are rotatable together. The inner peripheral edge of the retainer ring has a plurality of equidistantly-spaced detents that engage a plurality of rotational bearings on the annular fitting as the coupling ring and the retainer ring are rotated with respect to the annular fitting. The engagement between the detents and the bearings creates a ratcheting effect that restrains the coupling ring from rotating with respect to the fitting unless a manual effort is applied to it.

Abstract: An apparatus and method for utilizing natural energy in the production of electricity having an alternating current is disclosed wherein the natural energy is utilized to pressurize hydraulic fluid. The hydraulic fluid is temporarily stored within high pressure storage tanks to be utilized in the production of electricity. This electricity is supplied as needed to various consumers. Excess electricity which is generated by hydro electric devices driven by the pressurized hydraulic fluid is utilized to pressurize additional hydraulic fluid. The additional hydraulic fluid is then supplied to the high pressure storage tanks to be used at a later time for the production of electricity. In this way, excess electricity that is produced from the pressurized hydraulic fluid is reconverted into pressurized hydraulic fluid which may be stored in the high pressure storage tanks until needed.