Abstract: Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial treatment.

Abstract: Functionalized twin base linkers (TBLs) bind to and deactivate viruses by preventing their entry into cells. Functionalization of TBLs allows them to specifically bind to surface proteins of viruses, where they form structures that limit virus entry into cells and prevent viruses from replicating.

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

Abstract: A method for treating bacterial infection or cancer is provided. The method includes administering to a subject in need thereof an effective amount of a composition containing nanoparticles containing Ag and either Pt or Pd.

Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.

Abstract: Methods disclosed herein provide for an environmentally-friendly approach that employ citric extracts from fruits as unique reducing and stabilizing agents for making a tellurium nanomaterial. A particular method of making a tellurium nanomaterial includes combining citrus fruit extract with a tellurium salt to form a mixture of citrus fruit extract and dissolved tellurium salt; and heating the mixture of citrus fruit extract and dissolved tellurium salt, thereby making the tellurium nanomaterial. The resulting nanoparticles exhibit enhanced and desirable biomedical properties toward treatment of both infectious diseases and cancer.

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

Abstract: The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.

Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.

Abstract: Tellurium nanowires synthesized using green chemistry methods and having unique morphologies and functional properties are provided. The nanowires have a core of hexagonal crystal phase tellurium and a polymer coating, and can be used for treating cancer without apparent cytotoxicity toward normal human cells.

Abstract: Methods for creating nanostructured surface features on polymers and polymer composites involve application of low pressure during curing of solid polymer material from a solvent solution. The resulting nanoscale surface features significantly decrease bacterial growth on the surface. Polymer materials having the nanoscale structuring can be used in implantable medical devices to inhibit bacterial growth and infection.

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

Abstract: Methods of manufacturing produce metal implants having nano-modified surfaces that contain antimicrobial properties. The methods may include immersing the implant in an acid, rinsing the acid-treated implant in an aqueous cleaner, and thereafter heating the rinsed implant. The nano-modified implants described herein may contain an increased surface roughness; surface features with increased width or height; and/or decreased surface energy. The implants that result from these methods contain a nano-modified surface that is resistant to microbial cell adhesion and ultimately reduce biomaterials-related infections at the implant site.

Abstract: Methods for creating nanostructured surface features on polymers and polymer composites involve application of low pressure during curing of solid polymer material from a solvent solution. The resulting nanoscale surface features significantly decrease bacterial growth on the surface. Polymer materials having the nanoscale structuring can be used in implantable medical devices to inhibit bacterial growth and infection.

Abstract: The present invention is directed to methods for inhibiting growth of bacteria and to nanometer scale surfaces having antibacterial properties.

Abstract: A nanoparticle formulation of tellurium nanorods. The tellurium nanoparticles are prepared using polyvinylpyrrolidone (PVP), which creates a functionalized coating on the outside of the particles. The nanorods have been shown to have antibacterial properties against both Gram-positive and Gram-negative bacteria, as well as anticancer properties when tested with human melanoma cells.

Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.

Abstract: The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.

Abstract: Methods, systems, and kits provide robust and biologically active coatings for implanted medical devices. The methods are based on electrostatic attraction between a conductive or non-conductive material surface on the medical device and a coating material including a charged biopolymer or pharmaceutical agent. Surface charge is induced or enhanced in the conductive or non-conductive material using a physical method. The methods are applicable to a wide variety of conductive or non-conductive substrate materials and coatings containing any of a wide variety of biological molecules and pharmaceutical agents.

Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.