Patents by Inventor Thomas Jeffrey Dunn

Thomas Jeffrey Dunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing ioversol
    Patent number: 6596904
    Abstract: The present invention discloses a new process for producing ioversol (marketed as OPTIRAY®) comprising: (a) reacting 5-amino-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopthalamide with chloroacetyl chloride in a polar aprotic solvent or combinations thereof to produce N,N′-bis[2,3-di(2-chloroacetoxy)propyl]-5-(2-chloroacetamido)-2,4,6-triiodoisophthalamide; (b) reacting the product of (a) with a base to produce N,N′-bis(2,3-dihydroxypropyl)-5-(2-chloroacetamido)-2,4,6-triiodoisopthalamide; (c) reacting the product of (b) with an alkylating agent capable of producing a hydroxyethylated product in the presence of a base and water to produce N,N′-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) (2-chloroacetamido)]-2,4,6-triiodoisopthalamide; and (d) reacting the product of (c) in water and acetate ions to produce ioversol.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: July 22, 2003
    Assignee: Mallinc Krodt Inc
    Inventors: Thomas Jeffrey Dunn, David H. White, Mills Thomas Kneller, Michelle M. Jones, Narciso Ocampo Doran, III, Allan R. Bailey
  • Process for producing ioversol
    Patent number: 5648536
    Abstract: The present invention discloses a new process for producing ioversol (marketed as OPTIRAY.RTM.) comprising:(a) reacting 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopthalamide with chloroacetyl chloride in a polar aprotic solvent, or combinations thereof, to produce N,N'-bis[2,3-di(2-chloroacetoxy)propyl]-5-(2-chloroacetamido)-2,4,6-triiod oisophthalamide;(b) reacting the product of (a) with sodium hydroxide to produce N,N'-bis(2,3-dihydroxypropyl)-5-(2-chloroacetamido)-2,4,6-triiodoisopthala mide;(c) reacting the product of (b) in water and sodium acetate to produce N,N'-bis(2,3-dihydroxypropyl)-5-glycolamido-2,4,6-triiodoisopthalamide; and(d) reacting the product of (c) with an alkylating agent capable of producing hydroxylhylated product in the presence of a base and water to produce ioversol.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Inventors: Thomas Jeffrey Dunn, David H. White, Mills Thomas Kneller, Michelle M. Jones, Narciso Ocampo Doran, III