Patents by Inventor Thomas Jessell
Thomas Jessell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7632679Abstract: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of a Wnt signalling pathway, a modulator of Wnt-dependent neural differentiation, a modulator of a BMP signalling pathway, a modulator of BMP-dependent neural differentiation, a modulator of a Hh signalling pathway, and a modulator of Hh-dependent neural differentiation. Also provided are modulators identified by these methods.Type: GrantFiled: February 26, 2004Date of Patent: December 15, 2009Assignee: The Trustees of Columbia University in the City of New YorkInventors: Thomas Jessell, Hynek Wichterle, Sara Wilson
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Patent number: 7390659Abstract: The present invention provides a method for inducing differentiation of an embryonic stem cell into a differentiated neural cell. The present invention further provides a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. Additionally, the present invention provides a method for repopulating a spinal cord in a subject, and a method for treating nervous tissue degeneration in a subject in need of treatment. The present invention further provides neural progenitor cells, differentiated neural cells, and uses of same. Also provided is a transgenic non-human animal containing the differentiated neural cells. The present invention is further directed to a method for isolating a population of differentiated neural cells. Finally, the present invention provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.Type: GrantFiled: July 16, 2002Date of Patent: June 24, 2008Assignee: The Trustees of Columbia University in the City of New YorkInventors: Thomas Jessell, Hynek Wichterle, Ivo Lieberam
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Publication number: 20070224650Abstract: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of an FGF signalling pathway, a modulator of FGF-dependent neural differentiation, a modulator of a retinoid signalling pathway, and a modulator of retinoid-dependent neural differentiation. Also provided are modulators identified by these methods.Type: ApplicationFiled: August 25, 2006Publication date: September 27, 2007Inventors: Thomas Jessell, Hynek Wichterle, Sara Wilson, Ivo Lieberam
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Publication number: 20070185024Abstract: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of a Wnt signalling pathway, a modulator of Wnt-dependent neural differentiation, a modulator of a BMP signalling pathway, a modulator of BMP-dependent neural differentiation, a modulator of a Hh signalling pathway, and a modulator of Hh-dependent neural differentiation. Also provided are modulators identified by these methods.Type: ApplicationFiled: August 25, 2006Publication date: August 9, 2007Inventors: Thomas Jessell, Hynek Wichterle, Sara Wilson, Ivo Lieberam
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Publication number: 20050186628Abstract: This invention provides an isolated vertebrate nucleic acid molecule which encodes dorsalin-1. This invention also provides a nucleic acid probe capable of specifically hybridizing with a sequence included within the sequence of a nucleic acid molecule encoding a dorsalin-1. The invention also provides a vector and host vector system for the production of a polypeptide having the biological activity of dorsalin-1 which comprises the above-described vector in a suitable host. This invention also provides a purified vertebrate dorsalin-1. This invention provides a method for stimulating neural crest cell differentiation, a method for regenerating nerve cells, a method for promoting bone growth, a method for promoting wound healing and a method for treating neural tumor using purified dorsalin-1. This invention further provides a pharmaceutical composition comprising purified dorsalin-1 and a pharmaceutically acceptable carrier. Finally, this invention provides an antibody capable of binding to dorsalin-1.Type: ApplicationFiled: April 15, 2005Publication date: August 25, 2005Inventors: Thomas Jessell, Konrad Basler, Toshiya Yamada
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Patent number: 6670451Abstract: Netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents are provided.Type: GrantFiled: October 29, 2001Date of Patent: December 30, 2003Assignees: The Regents of the University of California, Columbia UniversityInventors: Marc Tessier-Lavigne, Tito Serafini, Timothy Kennedy, Marysia Placzek, Thomas Jessell, Jane Dodd
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Publication number: 20030049248Abstract: Netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents are provided.Type: ApplicationFiled: October 29, 2001Publication date: March 13, 2003Applicant: The Regents of the University of California Columbia UniversityInventors: Marc Tessier-Lavigne, Tito Serafini, Timothy Kennedy, Marysia Placzek, Thomas Jessell, Jane Dodd
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Patent number: 6309638Abstract: Netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents are provided.Type: GrantFiled: January 25, 2000Date of Patent: October 30, 2001Assignees: The Regents of the University of California, Columbia UniversityInventors: Marc Tessier-Lavigne, Tito Serafini, Timothy Kennedy, Marysia Placzek, Thomas Jessell, Jane Dodd
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Patent number: 6096866Abstract: Netrins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents are provided.Type: GrantFiled: June 7, 1995Date of Patent: August 1, 2000Assignees: The Regents of the University of California, Columbia UniversityInventors: Marc Tessier-Lavigne, Tito Serafini, Timothy Kennedy, Marysia Placzek, Thomas Jessell, Jane Dodd
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Patent number: 6017714Abstract: Netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents are provided.Type: GrantFiled: June 7, 1995Date of Patent: January 25, 2000Assignees: The Regents of the University of California, Columbia UniversityInventors: Marc Tessier-Lavigne, Tito Serafini, Timothy Kennedy, Marysia Placzek, Thomas Jessell, Jane Dodd
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Patent number: 5565331Abstract: A novel classes of neural axon outgrowth promoting and orienting proteins, nucleic acids encoding such proteins and receptors which selectively bind such proteins are disclosed. The disclosed neural axon outgrowth promoting and orienting proteins include the laminin-related p75/p78 family; a family of vertebrate proteins which promote axon outgrowth and/or orientation, and p75/p78 family-specific receptors, including receptors found on spinal nerve axons, especially growth cones. Also disclosed are agents including peptides derived from the disclosed neural axon outgrowth promoting proteins capable of effecting axon outgrowth, orientation and regeneration. These agents provide small molecular weight modulators of nerve cell growth useful in the treatment of neurological disease and injury.Type: GrantFiled: November 12, 1993Date of Patent: October 15, 1996Assignee: The Regents of the University of CaliforniaInventors: Marc Tessier-Lavigne, Tito Serafini, Timothy Kennedy, Merysia Placzek, Thomas Jessell, Jane Dodd