Patents by Inventor Thomas Kammermeier

Thomas Kammermeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid
    Patent number: 8034837
    Abstract: The present invention relates to a new crystalline modification of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,S-dihydro-1H-pyrrolizin-S-ylacetic acid which is referred to as polymorph B. It has a peak in the solid state 13C-NMR spectrum (with adamantane as external reference standard; CH group d=29.45 ppm) in the range from 179.8 to 180.2 ppm and can be processed directly to a pharmaceutical formulation.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: October 11, 2011
    Assignee: Merckle GmbH
    Inventors: Wolfgang Albrecht, Thomas Kammermeier, Hans-Gunter Striegel, Philipp Merckle, Stefan Laufer
  • Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-Phenyl-2,3-Dihydro-1h-Pyrrolizin-5-Ylacetic Acid
    Publication number: 20090209610
    Abstract: The present invention relates to a new crystalline modification of 6-(4-chlorophenyl)-2,2-dmethyl-7-phenyl-2, S-dihydro-1H-pyrrolizin-S-ylacetic acid which is referred to as polymorph B. It has a peak in the solid state 13C-NMR spectrum (with adamantane as external reference standard; CH group d=29.45 ppm) in the range from 179.8 to 180.2 ppm and can be processed directly to a pharmaceutical formulation.
    Type: Application
    Filed: March 20, 2006
    Publication date: August 20, 2009
    Applicant: Merckle GmgH
    Inventors: Wolfgang Albrecht, Thomas Kammermeier, Hans-Gunter Striegel, Philipp Merckle, Stefan Laufer
  • Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid
    Patent number: 7078535
    Abstract: The invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid, in which 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is reacted with ?-bromo-4-chloroacetophenone with formation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine and the acetic acid group is introduced into the 5-position, 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole being obtained by hydrogenation of 2,2-dimethyl-4-oxo-5-phenylvaleronitrile or a ketal thereof. The invention also relates to processes for the preparation of intermediates occurring in the above process.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: July 18, 2006
    Assignee: Merckle GmbH
    Inventors: Gerd Dannhardt, Thomas Kammermeier, Philipp Merckle, Hans-Günter Striegel, Stefan Laufer
  • Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid
    Publication number: 20040236117
    Abstract: The invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid, in which 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is reacted with &ohgr;-bromo-4-chloroacetophenone with formation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine and the acetic acid group is introduced into the 5-position, 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole being obtained by hydrogenation of 2,2-dimethyl-4-oxo-5-phenylvaleronitrile or a ketal thereof. The invention also relates to processes for the preparation of intermediates occurring in the above process.
    Type: Application
    Filed: June 4, 2004
    Publication date: November 25, 2004
    Inventors: Gerd Dannhardt, Thomas Kammermeier, Philipp Merckle, Hans-Gunter Striegel, Stefan Laufer
  • Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid
    Patent number: 6417371
    Abstract: The present invention relates to a process process for the preparation of the compound of the formula I where the compound of the formula III is reacted with oxalyl chloride and the product obtained is treated with hydrazine and an alkali metal hydroxide in the aqueous phase at elevated temperature, after treatment is complete a three-phase system is produced by addition of an ether and the compound of the formula I is obtained by acidifying the middle phase. The invention moreover relates to a polymorph of the compound of the formula I.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: July 9, 2002
    Assignee: Merckle GmbH
    Inventors: Thomas Kammermeier, Stefan Laufer, Philipp Merckle, Hans-Guenter Striegel
  • Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid
    Publication number: 20020028953
    Abstract: The present invention relates to a process process for the preparation of the compound of the formula I 1
    Type: Application
    Filed: January 26, 2001
    Publication date: March 7, 2002
    Applicant: Merckle GmbH
    Inventors: Thomas Kammermeier, Stefan Laufer, Philipp Merckle, Hans-Guenter Striegel