Patents by Inventor Thomas Kjaer
Thomas Kjaer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20200248224Abstract: The present application discloses a planar enzyme sensor for measuring the concentration of an analyte in a solution comprising a substrate of an electrically insulating material supporting an electrode layer of an electrically conductive material. The substrate and electrode layer have a plurality of layers disposed thereon which include an enzyme layer and a microporous outer layer covering the enzyme layer, wherein the outer layer comprises a continuous phase of a water-resistant polymer (e.g. a polyvinylacetate or an acrylate copolymer), a protein (e.g. an enzyme) embedded in the continuous phase, and possibly polytetrafluoroethylene particles. The enzyme and the polytetrafluoroethylene particles provide a controlled porosity to the outer membrane.Type: ApplicationFiled: November 23, 2016Publication date: August 6, 2020Inventors: Thomas KJAER, Thomas Steen HANSEN, Lydia Dahl Clausen
-
Publication number: 20200249151Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.Type: ApplicationFiled: April 21, 2020Publication date: August 6, 2020Inventor: Thomas KJAER
-
Patent number: 10663395Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.Type: GrantFiled: November 17, 2016Date of Patent: May 26, 2020Assignee: RADIOMETER MEDICAL APSInventor: Thomas Kjaer
-
Publication number: 20180372671Abstract: The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g.Type: ApplicationFiled: December 12, 2016Publication date: December 27, 2018Applicant: Radiometer Medical ApSInventors: Thomas KJAER, Lone MICHELSEN, Paul Ravn SOERENSEN, Hans Peter Blaabjerg JAKOBSEN
-
Publication number: 20180328842Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.Type: ApplicationFiled: November 17, 2016Publication date: November 15, 2018Inventor: Thomas KJAER
-
Publication number: 20170363568Abstract: A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the method comprising: determining sensitivities of the device for each of two or more calibration solutions, wherein each calibration solution has a different amount of enzyme modulator; determining a degree of modulation for each of the two or more calibration solutions; determining a degree of modulation for a sample to be measured; and calculating the sensitivity of the device for the sample, wherein said calculating comprises modifying the sensitivity of one of the two or more calibration solutions by a function comprising the determined degrees of modulation.Type: ApplicationFiled: December 14, 2015Publication date: December 21, 2017Inventors: Thomas Steen HANSEN, Thomas KJAER, Thomas Pedersen NYGAARD
-
Publication number: 20170363567Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.Type: ApplicationFiled: December 17, 2015Publication date: December 21, 2017Applicant: Radiometer Medical ApsInventor: Thomas KJAER
-
Publication number: 20170315139Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.Type: ApplicationFiled: December 14, 2015Publication date: November 2, 2017Inventors: Thomas KJAER, Thomas Pedersen NYGGARD
-
Patent number: 7959791Abstract: The present disclosure relates to an improved enzyme sensor comprising a cover membrane layer of a porous polymeric material, the outer surface and pore mouths of at least one face of the porous polymeric material being covered by a hydrophilic polymer. The sensor is useful determining the presence or amount of biological analytes, e.g., glucose, lactate, creatine, creatinine, etc.Type: GrantFiled: May 16, 2006Date of Patent: June 14, 2011Assignee: Radiometer Medical APSInventors: Thomas Kjaer, Lydia Dahl Clausen
-
Patent number: 7888061Abstract: A method is provided for stabilizing a creatinine sensor comprising creatininase as a bioactive molecule. The creatininase is stabilised by exposing it to a sufficient amount of a divalent manganese ion. This result may be obtained by exposing the sensor to a solution comprising the divalent manganese ion or by introducing a composition within the sensor providing sustained release of the divalent manganese ion.Type: GrantFiled: May 16, 2006Date of Patent: February 15, 2011Assignee: Radiometer Medical ApSInventors: Thomas Kjaer, Jens Østergaard, Tina Kristensen
-
Patent number: 7757622Abstract: According to the invention, a system is provided for connecting two vessels to each other or for connecting a vessel to a land-based structure for the transfer of objects. The system according to the invention comprises at least one projecting body adapted for attachment to one of the vessels and at least one receiving means adapted for attachment to the other vessel or to the land-based structure, the receiving means also comprising side members with recesses for cooperation with the projecting bodies. The invention also comprises a method for transferring material and a landing vessel for connecting to a cargo vessel.Type: GrantFiled: May 9, 2006Date of Patent: July 20, 2010Assignee: Umoe Mandal ASInventors: John Vonli, Ole Kristian Holen, Thomas Kjær, Peter Reed-Larsen
-
Publication number: 20090101426Abstract: Vehicle for operation on various grounds, including a hull (1) having a first sidehull (10) and a second sidehull (12), a front skirt device (14), a stern skirt device (16), and side skirt devices (18) having side skirt elements (54) movably fastened to the hull (1) by means of a platform arrangement (20) between a first position and a second position.Type: ApplicationFiled: October 17, 2007Publication date: April 23, 2009Applicant: UMOE MANDAL ASInventors: John Vonli, Nere G. Skomedal, Thomas Kjaer, Jon Taby, John Gifford, Kristian Mellingen, Arve Pedersen, John Tondevoldshagen, Magnus Tvete, Egil Jullumsto, Trond Sneve, Roy Isaksen, Anders Hjelmseth, John Stenberg, Tor Stokke
-
Publication number: 20090090288Abstract: According to the invention, a system is provided for connecting two vessels to each other or for connecting a vessel to a land-based structure for the transfer of objects. The system according to the invention comprises at least one projecting body adapted for attachment to one of the vessels and at least one receiving means adapted for attachment to the other vessel or to the land-based structure, the receiving means also comprising side members with recesses for cooperation with the projecting bodies. The invention also comprises a method for transferring material and a landing vessel for connecting to a cargo vessel.Type: ApplicationFiled: May 9, 2006Publication date: April 9, 2009Applicant: Umoe Mandal ASInventors: John Vonli, Ole Kristian Holen, Thomas Kjaer, Peter Reed-Larsen
-
Patent number: 7215988Abstract: The invention relates to a method and a sensor for measurement of tissue perfusion. The sensor is provided with a reservoir (4) for a fluid or gaseous tracer and a tracer-permeable barrier (3), a sub-surface of which is in contact with the surrounding tissue and another sub-surface of which is in contact with a detection cavity (5) which is connected to a suitable apparatus for the measurement of tracer concentration in the detection cavity. The concentration of the tracer in the detection cavity is a measure of perfusion in the surrounding tissue. According to another embodiment of the invention it is also possible to carry out measurements of perfusion in the surface layers of the skin or of an organ.Type: GrantFiled: October 4, 1999Date of Patent: May 8, 2007Inventors: Lars Riis Damgaard, Jens Kristian Gundersen, Lars Hauer Larsen, Thomas Kjaer
-
Publication number: 20060275859Abstract: The present disclosure relates to an amperometric enzyme sensor including a water-containing spacer layer in contact with an electrode. The sensor is useful determining the presence or amount of biological analytes, e.g. glucose, lactate, creatine, creatinine, etc.Type: ApplicationFiled: May 16, 2006Publication date: December 7, 2006Inventor: Thomas Kjaer
-
Publication number: 20060275857Abstract: The present disclosure relates to an improved enzyme sensor comprising a cover membrane layer of a porous polymeric material, the outer surface and pore mouths of at least one face of the porous polymeric material being covered by a hydrophilic polymer. The sensor is useful determining the presence or amount of biologicial analytes, e.g., glucose, lactate, creatine, creatinine, etc.Type: ApplicationFiled: May 16, 2006Publication date: December 7, 2006Inventors: Thomas Kjaer, Lydia Clausen
-
Publication number: 20060275860Abstract: A method is provided for stabilising a creatinine sensor comprising creatininase as a bioactive molecule. The creatininase is stabilised by exposing it to a sufficient amount of a divalent manganese ion. This result may be obtained by exposing the sensor to a solution comprising the divalent manganese ion or by introducing a composition within the sensor providing sustained release of the divalent manganese ion.Type: ApplicationFiled: May 16, 2006Publication date: December 7, 2006Inventors: Thomas Kjaer, Jens Ostergaard, Tina Kristensen
-
Publication number: 20050124867Abstract: The present invention relates to a sensor for measuring tissue perfusion comprising a diffusionally permeable reservoir and at least two diffusionally permeable detector chambers, in which sensor at least two diffusionally permeable detector chambers are located in different distances from the reservoir and that the at least two detector chambers are also located in different distances from any additional diffusionally permeable reservoir. Furthermore the present invention relates to a method for measuring tissue perfusion in which method a tracer gas is measured in separate detection chambers located in increasing distance from a reservoir comprising at least one tracer gas.Type: ApplicationFiled: December 20, 2002Publication date: June 9, 2005Inventors: Thomas Kjaer, Lars Damgaard, Jens Gundersen, Lars Larsen
-
Patent number: 6596154Abstract: The inventive microsensor and method for regulating the sensitivity primarily aims at measuring the nitrate concentration in a surrounding medium by use of a concept named “Migrational Sensitivity Control” (MSC). The sensitivity of the sensor is regulated by impressing an electrical potential difference or an electrical current between a surrounding medium, e.g. waste water, containing a primary substance to be measured, and a substance chamber inside the microsensor. The microsensor contains bacteria which metabolizes the primary substance into a secondary substance, the concentration of which is proportional to the conentration of the primary substance to be measured. By measuring the concentration of the secondary substance the concentration of the first substance can be found. By varying the impressed voltage or current, the sensitivity of the microsensor can be controlled.Type: GrantFiled: August 25, 2000Date of Patent: July 22, 2003Assignee: Unisense Aps.Inventors: Thomas Kjær, Lars Hauer Larsen
-
Patent number: 6225108Abstract: The invention relates to a microsensor for the measurement of the presence and the concentration of a primary medium, for example nitrate, in an environment where the microsensor is placed. The microsensor has a casing which surrounds a transducer and a reservoir containing nutrients. The transducer has a tip placed at a distance from the opening of the casing. Between the transducer tip and the opening is a reaction chamber with bacteria. The bacteria metabolises the primary medium (nitrate) into a secondary medium (nitrous oxide) which is detected by the transducer. The casing has a passage that stretches to the reservoir behind the transducer tip. Through the passage nutrients are fed to the bacteria whereby their activity can be maintained.Type: GrantFiled: May 7, 1999Date of Patent: May 1, 2001Inventors: Lars Hauer Larsen, Niels Peter Revsbech, Thomas Kjær