Abstract: A power cable or a hybrid power-data cable includes power conductors and a plurality of continuity wires positioned radially outside of the power conductors. The continuity wires are positioned relative to the power conductors such that a cut in the cable will sever one of the plurality of continuity wires before a cut into the power conductors can occur.

Abstract: A semiconductor device includes a semiconductor substrate and an antireflective conductive layer. The antireflective conductive layer includes a metal layer disposed on the semiconductor substrate and defining at least one array of apertures through the metal layer. Each of the apertures has a width of no more than 5 ?m and a distance between each aperture and its nearest neighboring aperture is no more than 10 ?m. The antireflective conductive layer also includes a solid material filling each of the apertures, wherein the solid material has an index of refraction of at least 1.1.

Abstract: Inhibition of RNA function, and treatment or control of diseases or conditions, e.g. infectious diseases such as viruses and viral infections (including HIV) and microbial infections, by the contacting of the RNA with a compound having a central or core structure comprising three fused rings containing from 12 to 15 ring atoms, the central ring including at least one heteroatom selected from nitrogen, oxygen and sulfur, the atoms of the three-ring core structure being optionally substituted with substituents such as halogens, cyano, and/or various substituted or unsubstituted aliphatic and/or heteroaliphatic moieties, or contacting the RNA with yohimbine, usnic acid or N-{4-[2,5-Dioxo-1-(4-trifluoromethoxy-phenyl)-pyrrolidin-3-yl]-phenyl}-2,2,2-trifluoro-acetamide. Preferred compounds are various phenothiazines, including both known and novel compounds.

Abstract: Molecules are disclosed that interact with the cellular components involved in conversion of PrPC to PrPSc. The molecules disclosed can be small molecules, peptides or protein analogs, e.g. analogs of PrPC. In one embodiment, these molecules interfere with prion formation and/or replication, e.g. by preventing interactions of proteins involved in a prion complex or by interfering with &bgr;-sheet formation. In another embodiment, the molecules of the invention promote PrPC conversion to PrPSc, e.g. by binding to PrPC and facilitating a conformational change from PrPC to PrPSc.

Abstract: A protein designated Prion Protein Modulator Factor (PPMF) is disclosed which protein is an auxiliary factor in prion replication. PPMF is primarily characterized by its ability to bind to PrP.sup.C and facilitate a conformational change from PrP.sup.C to PrP.sup.Sc. A discontinuous epitope on PrP.sup.C comprising residues 172, 215 and 219 of human PrP.sup.C binds PPMF which is encoded by a nucleotide sequence derived from an organism selected from the group consisting of cow, sheep, mouse, hamster and human. In converting PrP.sup.C to PrP.sup.Sc the PPMF forms a PrP.sup.C /PrP.sup.Sc complex and is a rate limiting compound in the formation of that complex. Molecules, including antibodies, which bind PPMF or its epitope on PrP.sup.C are useful in the treatment of prion disease. Pharmacophores of the PrP.sup.C epitope are disclosed as are useful therapeutics and pharmacophores of the PPMF surface which binds PrP.sup.C. Animals resistant to prion disease are taught as are genes for producing such animals.

Abstract: The present invention includes an injection molded lid comprising a closed annular rim, a skirt fixed to and extending downwardly from the rim and a film sealed to the bottom side of the rim to cover the open space within the rim. The rim and skirt are molded as a single monolithic lid preform, with the skirt being fixed near the outer peripheral edge of the rim. The film is sealed along the inner peripheral edge on the bottom side of the rim. This device allows for a prospective consumer to view the contents of the container before purchasing it. In addition to the lid device, a method is provided of forming a closure to seal a food container. A lid preform is injection molded as a monolithic unit comprising a skirt and a closed rim. Then the film is sealed along the entire length of the inner peripheral edge on the bottom side of the rim. This method allows for forming a sturdy closure capable of maintaining the integrity of its original seal with the container as well as its seal with the film.