Abstract: Described herein are systems and methods for sensing an analyte concentration and delivering a composition to a subcutaneous space of a subject comprising a sensing cannula, which comprises an electrode for detecting the analyte concentration in the subcutaneous space.

Abstract: Described herein are systems and methods for creating a transport tube comprising a plurality of passages configured to deliver an composition from a source into the human subcutaneous space.

Abstract: The present disclosure provides methods of measuring of an analyte in a subject to remove a measurement artifact by using a forecasting model to determine the true analyst concentration in a subject. Also herein, the present disclosure provides parameters and models to estimate the true analyte concentration in a subject.

Abstract: The present disclosure provides systems and methods for managing blood glucose in a subject. An insulin delivery cannula may comprise a hollow tube comprising a proximal end and a distal end, wherein the proximal end is in fluid communication with a source of a concentrated insulin or insulin analog formulation of at least about 150 units per milliliter. The distal end may be configured to deliver the concentrated insulin or insulin analog formulation into a subcutaneous space. A continuous amperometric or coulometric glucose sensor may located no more than a pre-determined distance away from the distal end. An insulin pump may be fluidically coupled to the proximal end, and may be attached to the insulin delivery cannula directly or via an intervening tube. The glucose sensor and the insulin delivery cannula may be configured to be inserted into the subcutaneous space simultaneously by a single insertion device.

Abstract: The present disclosure provides systems and methods for managing blood glucose in a subject. An insulin delivery cannula may comprise a hollow tube comprising proximal and distal ends, the proximal end in fluid communication with an insulin source, and the distal end configured to deliver insulin into a subcutaneous space. An insulin infusion pump may be fluidically coupled to the proximal end, and attached to the insulin delivery cannula directly or via an intervening tube. The glucose sensor and the insulin delivery cannula may be configured to be inserted into the subcutaneous space simultaneously by a single insertion device. A lumen of the insulin delivery cannula may be contiguous with a lumen of tubing from the insulin infusion pump. Electrical conductors for the electrodes may be disposed on a wall of the tubing or attached to a surface of the tubing, and establish an electrical connection with an electronic module.

Abstract: A lightweight auxiliary power and forced air supply unit that may be used to provide electricity and forced air for use by an air conditioning system on a vehicle such as an aircraft. The unit includes a turbine (12), a generator (13), a forced air unit (14), a primary control unit (16), and a primary display and input control unit (17). The apparatus further includes an electronic sequence unit (18), a secondary display unit (19) and an ignition exciter unit (21), in addition to a modulated bleed air valve (22), a fuel pump (23), a fuel valve (24), and a fuel source (26). The apparatus also includes a heat sensor unit (27) and a fire protection unit (28), and connects to the electrical system buss (29) of the aircraft. As configured and as installed, this apparatus weighs less than two hundred pounds.