Abstract: Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed.

Abstract: Novel neurotrophic factor compositions are provided, obtained from lung tissue. The factors are found to be active on parasympathetic ganglion neurons enhancing acetylcholine activity. The compositions find use in the treatment of a number of eye disorders.

Abstract: Novel neutrotrophic factor compositions are provided, obtained from lung tissue. The factors are found to be active on parasympathetic ganglion neutrons enhancing acetylcholine activity. The compositions find use in the treatment of a number of eye disorders.

Abstract: A bolted rail fastening system comprising a rail mounted in a recessed area of a tie plate with the tie plate being secured to a cross-tie by means of coach screws extending downwardly therethrough. The rail is maintained in the recessed area by a pair of clips positioned at each side of the rail which will remain in position even if the nuts associated therewith become loose.

Abstract: Disclosed is a device for detecting temperatures which differ from a variable norm of particular use in detecting elevated temperatures in cattle. The device, one being attached to each animal, includes a square wave generator, an identification number encoder for outputting the identification number of the particular animal in the herd, a fever detector with an ambient temperature compensating circuit which provides output only when internal temperature of the animal is above a preset value for a given ambient temperature, and a transmitter which sends the identification code to a receiver. In certain embodiments, no separate fever detector is provided; rather the square wave generator outputs a frequency-modulated signal related to the internal body temperature.